Medical Affairs Director, US Rare Nephrology

AstraZeneca plc; Boston (MA); On-site; USD 207,000 - 310,000; Full time

Job summary

AstraZeneca plc is seeking a Medical Director to lead the development and implementation of the US aHUS medical plan within US Medical Affairs. The role provides medical leadership, strategic guidance, and cross-functional direction across KOLs and internal teams.

The incumbent will partner with executive leadership to shape late-phase plans for Rare Nephrology, translate complex data into strategic insights, and drive cross-functional collaboration across the US organization.

Qualifications

• Must have an MD, PhD or PharmD level degree.
• Significant experience in Medical Affairs and/or biopharmaceutical industry.
• Deep scientific and clinical expertise with ability to translate data into strategic insights.
• Proven ability to lead cross-functional initiatives and influence senior stakeholders.

Responsibilities

• Lead development and implementation of the US aHUS medical plan and strategy.
• Provide medical leadership and strategic direction to US MA activities.
• Develop and execute late-phase plans for Rare Nephrology in collaboration with leadership.
• Oversee KOL engagement, advisory boards, and cross-functional field medical activities.
• Ensure medical review and alignment with ISR proposals and external education.
• Support organization with strategic medical input to brand strategy and training programs.

Skills

Medical leadership

Strategic planning

KOL engagement

Cross-functional leadership

US healthcare knowledge

Education

MD/PhD/PharmD

Job description

In collaboration with US and global medical and cross-functional colleagues, the Medical Director will lead the development and implementation of the aHUS strategic medical plan for US Medical Affairs, providing medical leadership, insights, and strategic direction across functions.

Responsible for the following:

• Leading the development and implementation of the US strategy and plan for US MA activities for aHUS by providing medical leadership, insight and strategic guidance to the US aHUS medical team.
• In partnership with the Executive Medical Director, providing medical strategic and tactical plans for late-phase pipeline program for Rare Nephrology as well as future LCM and potential late phase pipeline programs in the therapeutic area.
• Leading the situational assessment of the patient journey and the US product strategy development including harmonization of activities involving KOLs cross-functionally.
• Developing in-year medical strategy and tactical plan for the US Medical Affairs team for aHUS
• Contributing scientific and medical acumen as well as the US perspective to registration programs working closely with GMA
• Providing medical review and assurance of alignment with aHUS/Rare Nephrology strategic areas of interest for Investigator Sponsored Research (ISR) proposals.
• Providing medical guidance, as appropriate, regarding scientific communication, internal medical training, external medical education (CME, Symposia, medical education), Medical Information.
• Providing strategic medical leadership and appropriate medical input to cross-functional brand strategy
• Support Head of US Rare Hematology & Nephrology with team’s performance in terms of goals and delivery of US medical plans.
• Serving as a medical expert and resource within Alexion in support of the therapeutic area.
• Leading content development and presentation for external medical education programs and other medical initiatives.
• Developing, conducting, or contributing to therapeutic training programs for Alexion personnel.
• Establishing strategic partnerships with Centers of Excellence and KOLs in areas of scientific interest and serving asa conduit for flow of information both out to the medical community and into the company.
• Working closely with the Field Medical Team (Medical Science Liaisons and Field Directors) in the development and execution of US KOL medical engagement strategy as well as the development and implementation of the field medical strategic plan.
• Establishing and/or enhancing partnerships with key academic institutions and developing relationships withkey thought leaders.
• Planning, designing and managing medical Advisory Boards and gathering insight from national/regional/local medical Advisory Boards or other insight-gathering activities.
• Contribute to collaborations and engagements with professional societies and patient advocacy organizations in the therapeutic area

You will need to have:

• Must have an MD, PhD or PharmD level degree or equivalent- Nephrology, Hematology, or Immunology experience would be a plus.
• Significant experience in Medical Affairs and/or the biopharmaceutical industry, including development and execution of medical strategy.
• Deep scientific and clinical expertise with the ability to translate complex data into strategic medical insights.
• Demonstrated success leading cross-functional initiatives and influencing senior stakeholders in a matrix environment.
• Strong understanding of the US healthcare, regulatory, and reimbursement landscape.
• Proven ability to establish and maintain productive relationships with KOLs, academic institutions, professional societies, and external healthcare stakeholders.

The annual base payfor this position ranges from $206,827 to 310,240.80. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

07-Oct-2026

Closing Date

26-Nov-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.