Manufacturing Specialist II, DNA

AskBio Inc.; Durham (NC); On-site; USD 70,000 - 110,000; Full time

Job summary

AskBio Inc. in RTP, NC offers a Manufacturing Specialist II, DNA - Preclinical Manufacturing secondment focused on producing research-grade DNA constructs to support preclinical programs in gene therapy.

The role partners with the Lab Services and DNA Manufacturing teams to execute plasmid purifications, follow batch records, analyze data, and drive process improvements while maintaining rigorous documentation and safety practices in a fast-paced, collaborative environment.

Qualifications

• Degree in biology or engineering with 2+ years of relevant experience, or Master’s in biology/engineering.
• Experience with aseptic technique and preparing reagents.
• Strong attention to detail and multitasking in a fast-paced lab.
• Excellent written and verbal communication skills.
• Experience with lab management, fermentation, and DNA analysis software.

Responsibilities

• Perform hands-on plasmid purifications to support research-grade rAAV manufacturing.
• Follow batch records and document procedures in a detailed, organized manner.
• Analyze data and finalize batch records.
• Support process investigations and improvements with the team.
• Identify and implement SOP revisions and new procedures when needed.
• Inventory management of raw materials and lab supplies.
• Prepare manufacturing reports for scientists and management.
• Ensure labs are clean, organized and ready for use.

Skills

Attention to detail

Communication skills

Multitasking

Independent work

Team collaboration

Fast-paced lab adaptation

Education

Bachelor’s in biology or engineering

Master’s in biology or engineering

Tools

SnapGene

Fermentation

Job description

Opportunity for Secondment to AskBio

We’re pleased to share an exciting secondment opportunity at AskBio.

This role is available for a time period to be determined by leadership at both Bayer and AskBio. While most assignments range from one to two years, the exact duration will be based on business needs and mutual agreement.

This secondment offers a unique chance to broaden your experience, expand your knowledge, and contribute meaningfully to AskBio’s mission: to advance gene therapy and change the lives of patients around the world.

We look forward to seeing how our colleagues continue to grow and make an impact across the Bayer-AskBio partnership.

Our vision:

Pioneering science to create transformative molecular medicines.

Our mission:

Lead innovative science and drive clinical outcomes to transform people’s lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our mission.We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Position Summary

The Manufacturing Specialist II, DNA - Preclinical Manufacturing role is responsible for manufacturing and delivering a broad range of research-grade DNA constructs across various production scales to support preclinical research and development activities. The DNA manufactured by the team will support capsid technology development, early product development, intellectual property portfolio, and progression of internal and external early-stage gene therapy programs. This role provides an opportunity to gain industry manufacturing experience while providing opportunities to improve DNA purifications processes.

This role is based onsite in RTP, NC and reports to the Manager, Lab Services and DNA Manufactur

Job Responsibilities

• Perform hands‑on execution of plasmid purifications to support research grade rAAV manufacturing, technology improvements, and progression of early‑stage gene therapy programs.

• Follow batch records and document method procedures in a detailed, organized manner.

• Perform and evaluate data analysis at completion of test method; Summarize results and finalize batch records.

• Independently support process investigations, improvements, and optimization activities in collaboration with Senior Research Associate and DNA Process Development group.

• Identify, develop, and implement process improvements such as revisions to SOPs, Batch Records, Analytical Records, Formulation Records and initiating new procedures, when necessary.

• Inventory management of raw materials and laboratory supplies.

• Prepare manufacturing reports and data to present to scientists and management.

• Ensure lab areas are clean and organized. This includes ensuring equipment, supplies and raw materials are available and ready for use.

Minimum Requirements

• Bachelor’s degree in a biological or engineering discipline with 2+ years relevant work experience; or Master’s degree in a biological or engineering discipline; or High School Diploma with 6+ years of role relevant work experience
• Experience and/or demonstrated skills with one or more of the following techniques: aseptic technique, making reagents at desired dilutions or concentrations, Restriction Enzyme digest, Gel Electrophoresis, DNA quantitation, identifying annotated features on a plasmid map, bacterial cell culture, centrifugation, filtration, fermentation, and liquid chromatography
• Strong attention to detail, highly organized and the ability to multitask in a fast‑paced, highly interactive team environment
• Track record of independently delivering and interpreting experimental results
• Excellent verbal and written communication skills with the ability to maintain formal record keeping and interact effectively with internal/external stakeholders
• Comfortable working and learning in a fast‑paced team‑oriented laboratory environment
• undefined
• Experience with lab management, fermentation and molecular biology/DNA sequence design and analysis software

Preferred Education, Experience and Skills

• Master’s degree in a biological or engineering displine
• Experience with fermentation
• Experience with SnapGene

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‐related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at [phone] or sending us an email at [e-mail]