Manager Mass Spec and Proteomics Core

GlycoData; Pennsylvania; On-site; USD 68,200 - 102,300; Full time

Job summary

A leading research institution is looking for a Manager Mass Spec and Proteomics Core. The position involves overseeing mass spectrometric analyses, conducting advanced data analysis, and ensuring data quality. Candidates should have a Master's in a related field and 3-5 years of hands-on experience with mass spectrometry techniques, including familiarity with tools like Byonic and MSFragger. The role offers a competitive salary range of $68,200.00 - $102,300.00 and supports a collaborative research environment.

Qualifications

• 3-5 years of hands-on experience with mass spectrometry techniques and data interpretation required.
• Experience scripting in R or Python is preferable.
• PhD preferred.

Responsibilities

• Perform mass spectrometric analyses for protein identification and quantitation.
• Conduct advanced proteomics data analysis.
• Operate and maintain mass spectrometry instruments.
• Ensure data accuracy through rigorous quality control.
• Provide customer service and communicate effectively with researchers.
• Collaborate with others to support diverse research projects.

Skills

Mass spectrometry techniques

Data interpretation

Customer service

Collaboration

Troubleshooting

Education

Master’s degree in Biochemistry, Molecular Biology, Chemistry, or related field

Tools

TimsTOF Flex

QuickPlex SQ120

Byonic

DIANA

MSFragger

Scaffold

Job description

Manager Mass Spec and Proteomics Core – Penn State College of Medicine

Location: Hershey, PA

Posted on: January 09, 2026

Description:

Key responsibilities include, but are not limited to

Perform mass spectrometric analyses for identification and quantitation of proteins, peptides, oligonucleotides, carbohydrates, and lipids, including sample preparation, extraction, and quality control following established protocols.

Conduct advanced proteomics data analysis, including peptide/protein identification, quantitative workflows (label-based and label-free), PTM analysis, and bioinformatics interpretation using tools such as Byonic, DIANA, MSFragger, and Scaffold.

Operate and maintain mass spectrometry instruments (TimsTOF Flex, QuickPlex SQ120, etc.) to ensure optimal performance and uptime.

Ensure data accuracy and integrity through rigorous quality control (QC) and quality assurance (QA) procedures.

Maintain detailed and organized records of all experimental procedures, results, and quality metrics.

Provide exceptional customer service by communicating effectively with researchers, addressing inquiries, and ensuring timely delivery of high-quality analytical results.

Collaborate with investigators and colleagues to support diverse research projects and foster a team-oriented environment.

Troubleshoot assays and instrumentation to maintain efficient and reliable laboratory operations.

Stay current with advancements in mass spectrometry technologies and recommend improvements to workflows and instrumentation.

Train students and researchers on instrument operation, best practices, and data interpretation as needed.

Preferred Qualifications

Master’s in Biochemistry, Molecular biology, Chemistry, Analytical Science, or related field or equivalent experience required. PhD preferred.

Minimum 3–5 years of hands-on experience with mass spectrometry techniques and data interpretation required. Experience scripting in R or Python would be preferable.

MINIMUM EDUCATION, WORK EXPERIENCE & REQUIRED CERTIFICATIONS

Master's Degree 3+ years of relevant experience; or an equivalent combination of education and experience accepted Required Certifications: None

BACKGROUND CHECKS/CLEARANCES

Employment with the University will require successful completion of background check(s) in accordance with University policies.

Penn State does not sponsor or take over sponsorship of a staff employment Visa. Applicants must be authorized to work in the U.S.

SALARY & BENEFITS

The salary range for this position, including all possible grades, is $68,200.00 - $102,300.00.