Lead Scientist AI-Driven Antibody Display Engineering

TriNet Group; South San Francisco (CA); On-site; USD 135,000 - 241,000; Full time

Benefits offered by this job

Medical, Dental, and Vision Insurance

Life Insurance

Health Savings Account (HSA)

Flexible Spending Accounts (FSA)

401k plan and PTO

Job summary

TCG Labs-Soleil is seeking a Senior Scientist in Antibody Engineering to lead display-based antibody engineering and integrate AI-driven design with experimental validation. You will build and screen libraries (phage/yeast/mammalian) and collaborate with analytics, protein sciences, and in vitro teams to accelerate discovery and maturation of therapeutic antibodies.

You will work in a fast-paced biotech environment, applying computational design to real-world experiments, mentoring colleagues,

Qualifications

• Ph.D. with 5+ years postdoc or industry experience or M.S. with 10+ years industry experience in antibody discovery/engineering.
• Deep expertise in in vitro antibody discovery platforms including library construction and phage display.
• Experience designing and curating large antibody display libraries with AI/bioinformatics filtering.
• Proven ability to translate wet-lab results to in silico designs and refine computational models.
• Confident Python programming and Linux proficiency.
• Familiarity with structure prediction tools (AlphaFold/Rosetta) for collaboration with engineers.
• Strong problem-solving, multitasking, and project management in fast-paced environments.
• Excellent written and oral communication and collaboration across teams.

Responsibilities

• Develop and optimize display-based antibody engineering strategies (humanization, affinity maturation, bispecific formats).
• Design, construct, and screen antibody libraries using AI and computational tools.
• Lead in silico designs and translate outputs into library construction and screening.
• Evaluate cutting-edge display technologies (phage, yeast, mammalian) for discovery.
• Collaborate with protein sciences, analytics, and in vitro teams to integrate design with experiments.
• Stay current with trends in antibody engineering and computational protein design.
• Troubleshoot complex challenges in antibody discovery and characterization.
• Design and analyze experiments to deliver data-driven pipeline decisions.

Skills

Python programming

Linux/command-line

Cross-functional collaboration

Education

Ph.D. in relevant field

M.S. in related field

Tools

AlphaFold

Rosetta

Job description

Senior Scientist Antibody Engineering
August 2026

Position Summary:

Join our innovative team at TCG Labs-Soleil as an antibody engineering expert! We are seeking a highly skilled and motivated scientist to lead and advance our display-based antibody engineering capabilities within the cutting-edge Biologics Technology Group. In this pivotal role, you will design, build, and screen antibody display libraries by incorporating both AI-driven and conventional computational tools to bias library design toward higher hit rates and faster timelines. You will work closely with colleagues within Technology and collaborate cross-functionally with scientists across research and early development to drive technical excellence and support our growing pipeline of protein and antibody-based therapeutics.

Responsibilities:

• Directly contribute to the therapeutic pipeline by developing and optimizing display-based antibody engineering strategies, including humanization, affinity maturation, bispecific and multispecific antibody design, and innovative molecular formats.
• Design, construct, and screen phage (or possibly other display format) antibody libraries, applying AI-based and bioinformatic computational tools to bias library composition toward higher-affinity, higher-diversity candidates, improved hit rates, and efficient timelines.
• As a member of the computational engineering team, contribute to in silico designs and translate the outputs into library construction and screening strategy, and feeding experimental results back to sharpen future computational designs.
• Evaluate and implement cutting-edge antibody display technologies (e.g., phage, and possibly yeast or mammalian display) to enhance discovery and screening capabilities.
• Collaborate closely with protein sciences, analytics, and in vitro teams to integrate computational design with experimental validation.
• Drive technology innovation by staying current with emerging trends in antibody engineering and computational protein design, incorporating advances into the team's workflows.
• Troubleshoot and resolve complex technical challenges related to in vitro antibody discovery, engineering, and characterization.
• Design, implement, and analyze experiments efficiently, delivering data-driven insights that inform pipeline decisions.

Qualifications:

• Ph.D. with 5+ years of postdoctoral or industry experience or M.S. with 10+ years of industry experience in antibody discovery, engineering, biochemistry, bioinformatics, or related fields within biotech or pharma.
• Deep expertise in in vitro antibody discovery platforms, including synthetic and immune library construction and phage display for lead identification, optimization, affinity maturation and other engineering approaches (yeast or mammalian display experience a plus).
• Experience designing and curating large antibody display libraries, applying AI- or bioinformatics-based computational filtering, ranking, and diversity-optimization approaches to concentrate screening effort on the most promising candidates.
• Track record of closing the loop between wet-lab results and in silico models, using experimental data to refine computational design for subsequent rounds of library generation.
• Confident Python programming skills with the ability to write, debug, and maintain code, and comfort navigating a Linux/command-line environment.
• Working familiarity with computational structure prediction tools (e.g., AlphaFold, Rosetta, or similar) sufficient to collaborate effectively with structure-based antibody engineers.
• Strong problem-solving skills with the ability to troubleshoot complex molecular and biochemical challenges.
• Demonstrated ability to prioritize tasks and manage multiple projects in a dynamic, fast-paced environment.
• Meticulous attention to experimental detail, adept at multitasking and managing concurrent experiments without compromising quality.
• Excellent oral and written communication skills, with a track record of presenting scientific findings and contributing to publications or patents.
• Strong team player with the ability to lead cross-functional collaborations, including with computational scientists, and with flexibility to adapt to new scientific domains and quickly acquire new techniques.

Company Overview TCG Labs-Soleil, established in partnership with The Column Group , a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
For more details, visit TCGLSoleil.com and follow us on LinkedIn

EEO Statement TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to [e-mail].

Benefits and Compensation TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

The anticipated salary range for fully qualified candidates applying for this role will be $140,000 - $180,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity, as well as alignment with market data, including potential adjustments for geographic location.

Staffing Agencies TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to [e-mail] with the Subject Heading: Staffing Agency Request.

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