Lead Quantitative Scientist – AI, PK/PD & TB Modeling

UCSF Health; San Francisco (CA); On-site; USD 180,000 - 240,000; Full time

Job summary

UCSF Health in San Francisco seeks a senior quantitative scientist to lead development and application of advanced computational, pharmacometric, and ML methods to support MIDD in infectious disease drug development.

The incumbent will integrate preclinical, clinical, and real‑world data to build predictive models guiding regimen optimization, dose selection, and trial design, contributing to publications and strategic scientific initiatives.

Qualifications

• Bachelor’s degree in Computer/Computational/Data Science, or domain sciences with relevant specialization.
• Minimum 5 years relevant experience.
• Advanced knowledge of pharmacometrics, quantitative pharmacology, statistical modeling, and computational science.
• Demonstrated expertise in model‑informed drug development (MIDD).
• Experience developing mechanistic, PK/PD, Bayesian, or machine learning models.
• Advanced programming skills in Python and/or R.
• Ability to integrate large scale biological, clinical, and translational datasets.
• Demonstrated scientific leadership and independent research capability.
• Ability to communicate complex quantitative concepts to diverse audiences.
• Experience managing multiple concurrent research projects.

Responsibilities

• Lead development of PK/PD, mechanistic, Bayesian, QSP, and AI‑enabled models.
• Design predictive frameworks for TB regimen optimization.
• Develop translational strategies linking preclinical and clinical data.
• Integrate multi‑source datasets, develop computational workflows, and apply ML and statistics.
• Guide modeling strategy, collaborate with external investigators, and influence scientific decisions.
• Produce manuscripts, conference presentations, and grant development activities.
• Mentor trainees, lead interdisciplinary project teams, and establish best practices.

Skills

Python

R

Pharmacometric modeling

Bayesian modeling

QSP

AI/ML

Statistical modeling

Data integration

Scientific leadership

Communication

Education

Bachelor's degree

Master's degree

Tools

Python

R

Job description

Computational Research & Data Integration

Integrate multi-source datasets

Job Description

Job Function Summary:

Applies advanced computational, computer science, data science, statistical, and quantitative modeling principles, together with domain expertise in pharmacology, drug development, and translational science, to perform research and technology development supporting model-informed drug development (MIDD). Responsibilities include the design, development, implementation, validation, and application of computational models, machine learning approaches, simulation frameworks, and quantitative decision-support tools used to advance drug regimen development and clinical translation. The position integrates diverse preclinical, clinical, and real-world datasets to develop predictive models that support regimen optimization, dose selection, trial design, and translational decision-making. Research activities may include pharmacometric modeling, quantitative systems pharmacology (QSP), mechanistic and Bayesian modeling, artificial intelligence and machine learning methods, statistical analyses, and development of computational workflows and scientific software. This specialty exists for positions whose primary responsibility is to conduct independent quantitative research and use computational and data science technologies to advance biomedical and translational research.

Generic Scope

Technical leader with a high degree of knowledge in the overall field and recognized expertise in specific areas; problem-solving frequently requires analysis of unique issues / problems without precedent and / or structure. May manage programs that include formulating strategies and administering policies, processes, and resources; functions with a high degree of autonomy.

Custom Scope

The Savic Integrated Pharmacology Laboratory at UCSF seeks a senior quantitative scientist to lead the development and application of advanced computational, statistical, pharmacometric, and machine learning methodologies to support model-informed drug development (MIDD) within the PReDiCTR-TB Consortium. The incumbent will apply expertise in pharmacometrics, quantitative systems pharmacology, AI/ML, computational biology, and translational modeling to develop predictive frameworks that inform regimen optimization, dose selection, clinical trial design, and translational decision-making for infectious disease drug development. The position requires scientific leadership across multiple complex projects and collaboration with academic, industry, and regulatory stakeholders. The incumbent will independently design, develop, validate, and deploy quantitative models and computational tools that integrate preclinical, clinical, and real-world datasets, and will contribute to publications, grant applications, and strategic scientific initiatives across the consortium.

Responsibilities

DUTIES & ESSENTIAL JOB FUNCTIONS

Identify the functions or tasks that employees in the job perform. The essential functions should state the purpose of the work and the results to be accomplished, rather than how the function is performed. Of the tasks listed, what percentage of time is devoted to each? The more time employees spend on a function, the more likely it is that the function is essential. Generally, include those functions that account for 10% or more of the work, i.e., key items that contribute significantly to the achievement of the job. The functions should add up to 100%.

%

of time

Essential Function (Yes/No)

Key Responsibilities

(To be completed by Supervisor)

30

Yes

Quantitative Modeling & Simulation

Lead development of PK/PD, mechanistic, Bayesian, QSP, and AI-enabled models

Design predictive frameworks for TB regimen optimization

Develop translational strategies linking preclinical and clinical data

25

Yes

Computational Research & Data Integration

Integrate multi-source datasets

Develop computational workflows

Apply machine learning and statistical methods

15

Yes

Scientific Leadership

Guide modeling strategy

Collaborate with external investigators

Influence scientific decision making

15

Yes

Publications, Grants & Scientific Communication

Manuscripts

Conference presentations

Grant development

15

Yes

Mentoring & Technical Leadership

Mentor trainees

Lead interdisciplinary project teams

Establish best practices

0

0

0

0

0

0

100%

(To update total %, enter the amount of time in whole numbers (without the % symbol - e.g., 15, 20) then highlight the total sum (e.g., 1%) at the bottom of the column and press F9. The total sum should add up to 100%.)

Qualifications

Required Qualifications

• Bachelor's degree in Computer / Computational / Data Science, or Domain Sciences with computer / computational / data specialization or equivalent experience.
• Minimum 5 years relevant experience
• Advanced knowledge of pharmacometrics, quantitative pharmacology, statistical modeling, and computational science
• Demonstrated expertise in model-informed drug development (MIDD)
• Experience developing mechanistic, PK/PD, Bayesian, or machine learning models
• Advanced programming skills in Python and/or R
• Ability to integrate large-scale biological, clinical, and translational datasets
• Demonstrated scientific leadership and independent research capability
• Ability to communicate complex quantitative concepts to scientific and non-scientific audiences
• Experience managing multiple concurrent research projects
  
  

Preferred Qualifications

• Master's degree in Computer / Computational / Data Science, or Domain Sciences with computer / computational / data specialization preferred.
• Postdoctoral or industry experience in quantitative drug development
• QSP, AI/ML
• Pharmacogenomics, Toxicokinetics
• Clinical trial simulation, Infectious disease modeling
• TB experience, Regulatory interactions
• Grant writing experience