Lead Manufacturing Technician

Alnylam Pharmaceuticals; Norton (MA); Vor Ort; USD 83.000 - 112.000; Vollzeit

Benefits dieser Stelle

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid time off

Zusammenfassung

Alnylam Pharmaceuticals is seeking a Manufacturing Operator for the Norton, MA facility to run GMP production on a second shift (Wed–Sat, 2:00 pm–12:00 am). You will operate weigh/dispense, solution prep, chemical synthesis, UF/DF, HPLC, annealing, concentration and lyophilization, while ensuring accurate documentation and safety compliance.

The ideal candidate has a BS with 5–7 years in a regulated GMP setting, strong attention to detail, and the ability to train peers across multiple

Qualifikationen

• BS degree preferred with 5–7 years' experience in a regulated GMP facility.
• Must possess mechanical and scientific aptitude and document work clearly.
• Strong safety, compliance, and attention to detail.
• Ability to perform strenuous physical work in cleanroom environments.

Aufgaben

• Execute cGMP manufacturing operations using SOPs and batch records with accurate documentation.
• Troubleshoot equipment issues and coordinate with support groups to minimize impact.
• Maintain safe, compliant work environment and support safety investigations and CAPAs.
• Initiate deviations and eQMS records with QA and leadership.
• Lead and mentor peers across multiple manufacturing areas and support NPI/tech transfers.

Kenntnisse

Mechanical aptitude

Scientific aptitude

Team leadership

English communication

Time management

Safety compliance

Documentation

Problem solving

Ausbildung

Bachelor of Science (BS) degree

Tools

Unicorn

MS Word

Excel

Jobbeschreibung

Overview:

Under minimal supervision and with limited guidance, this individual will manufacture GMP products in Train 1 at the Norton Manufacturing Facility, ensuring safe, efficient and cGMP-compliant operations at all times. Responsibilities include but are not limited to operation of production equipment in the area of weigh/dispense, solution preparation, chemical synthesis, cleavage and deprotection, UF/DF, HPLC, annealing, concentration and lyophilization. Requires interaction with support groups (Facilities, Process Development, QC, QA and Validation etc.) to ensure accurate and well managed daily plant activities. This individual will be back-up to the shift supervisor.

This is an onsite, second-shift position based in Norton, MA. The schedule is Wednesday through Saturday, from 2:00 p.m. to 12:00 a.m.

Key Responsibilities:

• Execute cGMP manufacturing operations using approved SOPs and batch records, with timely, accurate documentation.
• Troubleshoot equipment and process issues, coordinate with support groups, and create work requests to minimize production impact.
• Maintain a safe, compliant work environment by promptly reporting incidents, identifying risks, and supporting safety investigations and CAPAs.
• Initiate and own deviations, CAPAs, and other eQMS records; complete investigations and required documentation revisions in partnership with QA and leadership.
• Maintain equipment and room logbooks, review executed batch records, and support right-first-time and cycle-time objectives.
• Serve as a qualified trainer and unit operation owner across multiple manufacturing areas, including complex operations such as chemical synthesis and HPLC; create or revise applicable Unicorn methods.
• Support continuous improvement, NPI and technology transfer activities, engineering test plans, validation protocols, and off-hours on-call needs as required.

Qualifications:

• Bachelors of Science (BS) degree preferred with a minimum of 5-7 years' experience in a regulated GMP facility. Minimum requirements may be substituted for the equivalent combination of education and experience in the industry.
• Must possess a mechanical and scientific aptitude and be able to clearly and thoroughly document all work on existing forms and records.
• Safety and Compliance: Demonstrated commitment to maintaining a safe, compliant work environment.
• Operational Excellence: Ability to support highly effective and efficient production operations, with strong attention to detail in both execution and documentation.
• Must be able to execute strenuous, sometimes repetitive physical work on manufacturing shift schedule in classified cleanroom environments.
• Ability to lift objects up to 50 lbs, and push/pull objects including bulk materials up to 250 lbs with assistance.
• Ability to wear half face and full-face respirators / PAPR as required for chemical processing.
• Strong organizational skills and ability to work independently as well as in a team setting.
• Ability to lead and mentor peers and interact with department management.
• Effective written and verbal English communication skills.
• Strong time management skills, attention to detail, and an ability to work in a team setting.
• Familiarity with Unicorn, MS Word and Excel software is a plus.
• Prior experience training peers preferred.
• Ability to support shift hours including days, nights, weekends, rotating shifts, on-call coverage, or extended hours

About Alnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Before applying, please review Alnylam's Candidate Privacy Notice regarding how Alnylam handles Personal Data you provide with your application for employment.

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The pay range below reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

U.S. Pay Range

$82,800-112,000 USD