Lead Design Engineer

System One; Pittsburgh, Northern (Allegheny County, KY); Hybrid; USD 100,000 - 150,000; Full time

Job summary

System One in Pittsburgh, PA is seeking a Lead Design Engineer to drive the design, development and optimization of advanced biomedical devices for human-relevant experimental systems.

The role focuses on fabrication, process development, and manufacturability to enable robust, scalable production, with opportunities for early-stage prototyping and progression toward higher maturity platforms.

Qualifications

• Bachelor’s degree in Biomedical Engineering, Mechanical Engineering, Electrical / Systems Engineering, or a related field.
• Minimum of 3 years of relevant experience in device design, prototyping, or fabrication.
• Experience with engineering design tools (e.g., CAD software).
• Strong problem-solving skills and attention to detail.
• Ability to work effectively in multidisciplinary research and engineering environments.

Responsibilities

• Design, prototype, and refine biomedical devices and components supporting advanced experimental system
• Develop and optimize fabrication processes to ensure consistency, quality, and scalability
• Contribute to selection and evaluation of materials, fabrication methods, and assembly workflows
• Perform testing and validation of device performance, including durability, reproducibility, and functional integrity
• Collaborate with scientific and engineering teams to align device design with experimental requirements
• Maintain documentation related to design iterations, fabrication processes, and quality control
• Troubleshoot device-related issues and implement design improvements
• Support coordination of engineering activities across multidisciplinary teams and contribute to project execution
• Contribute to preparation of technical documentation, reports, and related materials

Skills

CAD software

Problem solving

Team collaboration

Education

Bachelor's degree in relevant engineering field

Tools

CAD software

Job description

Title: Lead Design Engineer
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours

Overview: Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead Engineer to support the design, development, and optimization of advanced biomedical devices used in human-relevant experimental systems. This role focuses on device fabrication, process development, and manufacturability to enable robust, reproducible, and scalable production of experimental platforms. The position will contribute to both early-stage prototyping and advancement toward higher levels of technical maturity and deployment

Responsibilities:

• Design, prototype, and refine biomedical devices and components supporting advanced experimental system
• Develop and optimize fabrication processes to ensure consistency, quality, and scalability
• Contribute to selection and evaluation of materials, fabrication methods, and assembly workflows
• Perform testing and validation of device performance, including durability, reproducibility, and functional integrity
• Collaborate with scientific and engineering teams to align device design with experimental requirements
• Maintain documentation related to design iterations, fabrication processes, and quality control
• Troubleshoot device-related issues and implement design improvements
• Support coordination of engineering activities across multidisciplinary teams and contribute to project execution
• Contribute to preparation of technical documentation, reports, and related materials

Requirements:

• Bachelor’s degree in Biomedical Engineering, Mechanical Engineering, Electrical / System Engineering, or a related field
• Minimum of 3 years of relevant experience in device design, prototyping, or fabrication
• Experience with engineering design tools (e.g., CAD software)
• Strong problem-solving skills and attention to detail
• Ability to work effectively in multidisciplinary research and engineering environments

Preferred Qualifications

• Master’s or Ph.D. in a relevant engineering discipline
• Experience with fabrication of small-scale or precision-engineered devices, including Organs-on-Chips, injection molding, and CNC milling
• Familiarity with polymer-based materials and manufacturing processes
• Experience with iterative prototyping and design-for-manufacturing principles
• Experience working at the interface of engineering and biological systems