Lead CRA/ Principal CRA

Ladders; United States; Remote; USD 110,000 - 130,000; Full time

Benefits offered by this job

Competitive base salary

Health insurance and retirement plans

Life assurance and disability coverage

Employee wellbeing resources

Learning and development opportunities

Job summary

Ladders is seeking a Lead CRA/ Principal CRA to join a leader in the Pharmaceuticals & Biotech space. This remote role focuses on oncology trial oversight, site engagement, and monitoring quality across complex studies. You will partner with clinical sites, investigators, and internal teams to drive patient experience and study milestones while ensuring GCP compliance.

Location: Remote – US-based candidates only, no visa sponsorship. Compensation: $110,000 – $130,000 annually.

Qualifications

• Bachelor's degree in a scientific or clinical field required; advanced degree preferred.
• 8+ years of oncology trial monitoring experience, especially with solid tumors.
• 4 years of Phase I/III monitoring experience.
• Proven track record conducting on-site and remote monitoring visits independently.
• Proficiency with Veeva CTMS and Trial Master File (TMF) systems.
• Preferred experience supporting inspections and site/audit activities.

Responsibilities

• Develop and maintain strong relationships with clinical trial sites to enhance patient experience and expedite milestones.
• Promote sponsor clinical programs to sites and investigators.
• Conduct Monitoring Oversight Visits to assess CRA quality and site readiness for inspection.
• Execute site qualification for sponsor trials and support site selection.
• Lead Site Initiation, Monitoring and Close-Out visits to train CRAs in oncology trials.
• Review monitoring visit reports and ensure compliance with KRIs.
• Train CRAs and sites on GCP, protocols and study documents.

Skills

Oncology trial monitoring

Site engagement

GCP compliance

Remote monitoring

Veeva CTMS

TMF/audits

Education

Bachelor's degree in scientific/clinical field

Advanced degree preferred

Tools

Veeva CTMS

TMF systems

Job description

For our client, we are seeking a Lead CRA/ Principal CRA to join the team of a leader in the Pharmaceuticals & Biotech space. This remote role will focus on oncology trial oversight, site engagement, and monitoring quality across complex clinical studies. The position plays a key part in supporting study execution, inspection readiness, and consistent compliance with GCP and protocol requirements. You will partner closely with clinical sites, investigators, and internal teams to help drive patient experience and study milestones forward.

Location: Remote - US based candidates only, no visa sponsorship available

Compensation: $110,000 – $130,000 annually

Responsibilities

• Develop and maintain strong relationships with clinical trial sites to enhance patient experience and expedite study milestones.
• Promote the sponsor's clinical pipeline and programs to sites and investigators.
• Conduct Monitoring Oversight Visits to assess the quality of CRA monitoring and site readiness for inspection.
• Execute site qualification for sponsor trials, facilitating site selection promptly as required.
• Conduct Site Initiation, Monitoring, and Close-Out visits to train and onboard CRAs in oncology trials.
• Review and approve monitoring visit reports and ensure compliance with KRI metrics.
• Train CRAs and sites on GCP, protocols, and study documents.

Qualifications

• Bachelor's degree in a scientific or clinical field required; advanced degree preferred.
• 8+ years of oncology trial monitoring experience, especially with solid tumors.
• 4 years of Phase I/III monitoring experience.
• Proven track record of conducting on-site and remote monitoring visits independently.
• Proficiency with Veeva CTMS and Trial Master File systems is essential.
• Preferred experience supporting inspections and conducting audits of sites and TMF.

Benefits

• Competitive base salary and performance incentives.
• Comprehensive health programs including medical, dental, and vision coverage.
• Retirement and pension plans for financial security.
• Life assurance and disability coverage for peace of mind.
• Employee assistance and wellbeing resources to support mental health.
• Opportunities for learning and development through training programs.

Our client is an equal opportunity employer. We encourage you to apply even if you don’t meet every qualification—your background could be exactly what this team needs.