Lead Cell Therapy Process Development Scientist

Vertex Pharmaceuticals; Boston (MA); On-site; USD 104,000 - 156,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Comprehensive benefits

Job summary

Vertex is seeking a Scientist to join the Process Development team in Boston, MA. The role focuses on leading development studies for a cell-based drug candidate targeting diabetes, with occasional weekend work required.

The successful candidate will be a subject matter expert in bioprocess engineering and will work within a fast-paced, cross-functional environment. Key duties include designing experiments, mentoring associates, developing pluripotent stem cell culture methods, and communicating

Qualifications

• Experience designing and leading cell culture process development studies.
• Bioreactor design/scale-up experience and control.
• DOE and statistical analysis using JMP and related tools.
• Working knowledge of GMP in process development activities.

Responsibilities

• Design and execute experiments to develop robust manufacturing processes for cell therapy products and implement to support programs in clinical development.
• Mentor team of bioprocess scientific associates who will work closely together within a highly matrixed, cross-functional team to deliver program goals.
• Communicate effectively between departmental teams to develop plans for ongoing studies, including understanding experimental goals, developing schedules, and delegating work to the team.
• Develop expertise in pluripotent stem cell culture and differentiation to support process development, optimization, and characterization.
• Use engineering principles to develop solutions for technical issues with high degree of complexity.
• Document experimental procedures and results according to established guidelines in electronic lab notebook. Perform statistics and advanced analytics on experimental data.
• Communicate progress against plan, identifying and escalating business-critical issues affecting supply and timelines as necessary, providing recommendations, mitigations, and potential solutions.
• Collaborate effectively within departmental teams, engage in team discussions to resolve issues, and lead projects with a fully integrated team to facilitate successful outcomes.
• Coordinate long-range priorities and resources for own team, contributing to the overall goals of the department.
• Generate and review protocols and technical reports.

Skills

Cell culture process development

Bioreactor process control

DOE & statistics

GMP knowledge

Cross-functional collaboration

Aseptic technique

Education

Bachelor's degree in Chemical Engineering, Biomedical Engineering, Biology or related discipline

Tools

JMP

Job description

Vertex is seeking a Scientist to join the Process Development team in Boston, MA. The role focuses on leading development studies for a cell-based drug candidate targeting diabetes, with occasional weekend work required.

The successful candidate will be a subject matter expert in bioprocess engineering and will work within a fast-paced, cross-functional environment. Key duties include designing experiments, mentoring associates, developing pluripotent stem cell culture methods, and communicating