Lead Bioinformatics & Machine Learning Scientist (Epigenomics)

Natera; San Carlos (CA); In loco; USD 172.000 - 214.000; Tempo pieno

Descrizione del lavoro

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to advance research in Epigenomics in Oncology. You will develop ML methods for early cancer detection from cfDNA methylation data and provide technical leadership within a collaborative team.

The role emphasizes designing robust ML pipelines, mentoring colleagues, and coupling computational work with experimental design in a fast-paced environment in California. Strong ML, genomics, and cloud/HPC experience are essential.

Competenze

• PhD in Bioinformatics, CS, ML, or statistics; 4–8+ years post-PhD.
• Experience in cancer genomics/epigenomics; cfDNA methylation sequencing is a plus.
• Strong background in quantitative reasoning and statistical analysis; deep learning experience a plus.
• Proven track record developing computational methods for high-throughput sequencing data.
• Strong programming in Python with pandas, NumPy, scikit-learn.
• Experience with Linux, shell, Git, Nextflow/Snakemake, and cloud/HPC environments.
• Ability to perform hypothesis-driven research and communicate results clearly.
• Experience mentoring or technically leading other scientists.

Mansioni

• Drive technical workstreams from problem definition to final classifiers and downstream validation.
• Design, implement, and validate novel ML and statistical methods for cancer diagnostics.
• Promote best practices in interpretability, uncertainty estimation, and reproducibility.
• Build robust feature pipelines for cfDNA methylation and sequencing data.
• Collaborate with molecular biologists on experimental design and data QC.
• Mentor scientists and foster innovation and collaboration.
• Lead and participate in code and design reviews.

Conoscenze

Python

Pandas

NumPy

Scikit-learn

Shell scripting

Leadership

Statistical modeling

Machine learning

Formazione

PhD in Bioinformatics

Strumenti

Nextflow

Snakemake

Git

AWS

GCP

Linux

Descrizione del lavoro

Natera is currently seeking a Lead Bioinformatics & Machine Learning Scientist to contribute to research and development within our Bioinformatics Research and Development team, focused on Epigenomics in Oncology. The team develops machine learning methods for early cancer detection from cell-free DNA methylation data. The ideal candidate will have a strong background in machine learning and statistical modeling, as well as genomics and sequencing data analysis. The successful candidate will be instrumental in developing and expanding state-of-the-art machine learning methods for early detection of cancer, and will provide technical leadership and mentorship within a highly collaborative team.

Primary Responsibilities

• Drive technical workstreams within a collaborative team that takes methods from problem definition through delivery of final classifiers to downstream validation teams
• Design, implement, and validate novel machine learning and statistical methods to solve problems in cancer diagnostics
• Establish and promote best practices in model interpretability, uncertainty estimation, and reproducibility
• Design robust feature engineering and extraction pipelines tailored to cfDNA methylation and sequencing data
• Collaborate closely with molecular biologists on experimental design, ensuring data integrity and quality control
• Mentor other scientists and foster a culture of innovation, collaboration, and scientific excellence
• Lead and actively participate in code and design reviews

Qualifications

• PhD in Bioinformatics, Computer Science, Machine Learning, Statistics, or a related quantitative field, with 4 to 8+ years of post-PhD experience
• Hands-on experience in cancer genomics or epigenomics; experience with cell-free DNA or methylation sequencing data is a plus
• Strong foundation in quantitative reasoning, statistical analysis, and applied machine learning; experience with deep learning frameworks is a plus
• Proven track record of developing computational methods for high-throughput sequencing data analysis
• Strong programming skills, with hands-on experience in Python and its scientific library stack (pandas, NumPy, scikit-learn)
• Experience with Linux command-line tools, shell scripting, version control (Git), workflow managers (e.g., Nextflow, Snakemake), and cloud or HPC compute environments
• Ability to perform hypothesis-driven research, visualize findings, and summarize results in oral and written form
• Experience mentoring or technically leading other scientists

Compensation & Total Rewards

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

• Annual performance incentive bonus
• Long-term equity awards
• Comprehensive health benefits (medical, dental, vision)
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work-life benefits

Compensation Range

$172,000—$214,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

What We Offer

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @natera.com email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For More Information

• BBB announcement on job scams
• FBI Cyber Crime resource page