Lead, Analytical Development – Oligonucleotide & Small Molecule

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 159,000 - 207,000; Full time

Benefits offered by this job

401k

Healthcare coverage

ESPP

Job summary

Denali Therapeutics Inc. is seeking a Lead for the Oligonucleotide & Small Molecule CMC Analytical Development team.

You will mentor staff, set day-to-day priorities, and lead method development, qualification, validation, transfer, testing and material characterization with a hands-on lab presence. Responsibilities include guiding cross-functional teams across discovery, process chemistry, formulation, quality, and regulatory, and coordinating CRO/CDMO activities to meet program goals and

Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or related discipline with 7+ years of industry experience, or MS/BS with extensive experience.
• 5+ years hands-on analytical development experience for oligonucleotide and/or small-molecule products.
• Strong leadership and mentoring ability to manage a small team.

Responsibilities

• Lead and mentor the analytical development team, setting priorities and guiding data review.
• Oversee method development, qualification, validation, transfer, and testing for oligonucleotide and small-molecule materials.

Skills

Oligonucleotide analysis

CMC Analytical Development

Leadership

Regulatory documentation

Education

Ph.D. in Analytical Chemistry or related field

Tools

HPLC/UPLC

Mass spectrometry

GC

DSC/TGA

Job description

Denali Therapeutics Inc. is seeking a Lead for the Oligonucleotide & Small Molecule CMC Analytical Development team.

You will mentor staff, set day-to-day priorities, and lead method development, qualification, validation, transfer, testing and material characterization with a hands-on lab presence. Responsibilities include guiding cross-functional teams across discovery, process chemistry, formulation, quality, and regulatory, and coordinating CRO/CDMO activities to meet program goals and