Laboratory Operations Lead

Epicrispr Biotechnologies; San Francisco (CA); On-site; USD 100,000 - 160,000; Full time

Job summary

Epicrispr Biotechnologies is seeking a Laboratory Operations Lead to oversee the operational infrastructure of our R&D organization in San Francisco. The role coordinates day-to-day lab operations across BSL-1/2, procurement, vendor relationships, equipment, and EH&S, ensuring safe, compliant, and efficient labs.

The successful candidate will work cross-functionally with R&D and internal teams, develop processes, and implement cost-effective solutions to support evolving research programs in a

Qualifications

• Bachelor's degree in a relevant scientific, technical, laboratory operations, or related field.
• 2–4+ years of relevant experience in biotechnology, pharma, life sciences, or related research environments.
• Experience with laboratory operations, procurement, purchasing, vendor management, or laboratory infrastructure.
• Familiarity with laboratory biosafety, EH&S, compliance, or risk assessments.
• Familiarity with laboratory equipment maintenance and service providers.
• Experience developing or implementing laboratory processes, SOPs, or operational procedures.
• Familiarity with molecular biology, biochemistry, synthetic biology, cell culture, or related disciplines.
• Strong organizational, project management, and problem-solving skills.
• Ability to manage multiple priorities in a fast-paced environment and work independently.
• Strong communication and interpersonal skills for cross-functional collaboration.
• Demonstrated ability to evaluate alternatives and identify cost-saving opportunities.
• Commitment to safety, compliance, and operational excellence.

Responsibilities

• Coordinate day-to-day operations across BSL-1, BSL-2, CMC, cell biology, virus, and other research laboratories.
• Evaluate laboratory operational needs and make recommendations on equipment, supplies, and services.
• Lead laboratory procurement activities, including vendor evaluation, quotes, POs, and reconciliation.
• Develop and maintain relationships with laboratory suppliers, equipment vendors, and service providers.
• Coordinate installation, maintenance, calibration, repairs, and service activities for lab equipment.
• Develop and maintain SOPs, processes, and documentation to support safe, compliant operations.
• Support EH&S, biosafety, risk-management activities including risk assessments and waste management.
• Monitor practices and identify opportunities to improve safety, compliance, efficiency, and cost.
• Collaborate with R&D, Finance, Facilities, IT, Legal/Compliance to resolve operational issues.
• Provide guidance and training on equipment, processes, and procedures.
• Research and recommend new suppliers, equipment, products, and services.
• Support laboratory expansion and implementation of new capabilities.
• Exercise discretion and independent judgment in evaluating operational options.
• Perform other duties and special projects as needed.

Skills

Experience in lab operations

Procurement & vendor management

Laboratory infrastructure

Biosafety/EH&S

SOPs & process improvement

Molecular biology familiarity

Project management

Communication with scientists &外

Attention to safety & compliance

Education

Bachelor's degree in a relevant scientific/technical field

Job description

Epicrispr Biotechnologies is a biotechnology company pioneering gene-modulating therapies, leading with treatments for neuromuscular diseases. The company’s proprietary Gene Expression Modulation System (GEMS) enables precise and durable epigenetic modulation of gene expression, unlocking first-in-class treatments for previously untreatable conditions. Epicrispr’s lead program, EPI-321, is in clinical trials for FSHD, and the company is advancing additional gene-modulating therapies.

The Role

Epicrispr Biotechnologies is seeking a highly organized and solutions-oriented Laboratory Operations Lead to support the operational infrastructure of our growing research and development organization.

This role will coordinate laboratory operations, procurement, vendor relationships, equipment, and environmental health and safety activities to ensure our laboratories operate safely, efficiently, and in compliance with applicable requirements. The successful candidate will work cross-functionally with R&D and other internal teams, evaluate operational needs, develop and improve processes, and independently identify solutions to support the Company's evolving research programs.

This is an opportunity for someone who enjoys working in a dynamic biotech environment, managing multiple priorities, building efficient processes, and finding practical and cost-effective solutions to operational challenges.

Duties and responsibilities:

• Coordinate day-to-day operations across BSL-1, BSL-2, CMC, cell biology, virus, and other research laboratories.
• Evaluate laboratory operational needs and make recommendations regarding equipment, supplies, services, and other resources.
• Lead laboratory procurement activities, including sourcing, evaluating vendors, obtaining quotes, negotiating where appropriate, managing purchase orders, and reconciling orders.
• Develop and maintain strong relationships with laboratory suppliers, equipment vendors, service providers, and other external partners.
• Coordinate laboratory equipment installation, maintenance, calibration, repairs, and service activities.
• Develop and maintain laboratory SOPs, processes, and documentation to support safe, compliant, and efficient operations.
• Support laboratory EH&S, biosafety, and risk-management activities, including risk assessments, SDS/MSDS documentation, waste management, and related compliance requirements.
• Monitor laboratory practices and identify opportunities to improve safety, compliance, efficiency, and cost effectiveness.
• Partner with R&D, Finance, Facilities, IT, Legal/Compliance, and other teams to resolve operational issues and support business needs.
• Provide guidance and training to employees regarding laboratory equipment, processes, and operational procedures.
• Research and recommend new suppliers, equipment, products, and services based on scientific and operational needs.
• Support laboratory expansion, implementation of new capabilities, and other operational projects.
• Exercise discretion and independent judgment when evaluating operational alternatives, resolving issues, and making recommendations to management.
• Perform other duties and special projects as needed.

Qualifications

• Bachelor's degree in a relevant scientific, technical, laboratory operations, or related field.
• 2–4+ years of relevant experience, preferably in biotechnology, pharmaceutical, life sciences, or a related research environment.
• Experience with laboratory operations, procurement, purchasing, vendor management, or laboratory infrastructure.
• Experience or familiarity with laboratory biosafety, EH&S, compliance, or risk assessments.
• Familiarity with laboratory equipment maintenance and technical service providers.
• Experience developing or implementing laboratory processes, SOPs, or operational procedures.
• Familiarity with molecular biology, biochemistry, synthetic biology, cell culture, or another biological discipline.
• Strong organizational, project management, and problem-solving skills.
• Ability to manage multiple priorities in a fast-paced environment and work independently under general direction.
• Strong communication and interpersonal skills, with the ability to work effectively with scientists, vendors, contractors, and cross-functional partners.
• Demonstrated ability to evaluate alternatives, make sound recommendations, and identify opportunities for process improvement and cost savings.
• Strong attention to detail and commitment to safety, compliance, and operational excellence.