Intermediate Laboratory Science Professional

University of Colorado System; Aurora (CO); On-site; USD 53,000 - 70,000; Full time

Benefits offered by this job

Medical options

Dental options

Retirement 401(a) plan

Paid time off

Job summary

The University of Colorado Anschutz Medical Campus in Aurora, CO seeks an Intermediate Laboratory ScienceProfessional to support blood/tissue specimen handling and CAR T-cell vector development. You will process samples, perform DNA preparations, cloning, and lentiviral vector production, with strong attention to detail and documentation.

Responsibilities include collaborating with PIs, maintaining records, and preparing the lab for daily operations while ensuring safety and quality in a

Qualifications

• Bachelor's degree in biology or related field; substitution possible with relevant experience.
• 1 year of professional-level research experience.
• Preferred: Master's degree and 2+ years of research experience.
• Experience with biobanking and processing human blood/tissues is a plus.

Responsibilities

• Collaborate with PIs and clinicians on laboratory and research tasks.
• Process peripheral blood and bone marrow to isolate cells and plasma.
• Perform plasmid DNA preparations and quality assessment.
• Molecular cloning and verification of CAR T-cell vectors.
• Generate and document lentiviral vectors and production records.
• Analyze research data and assist in analytical testing processes.
• Prepare lab for daily operations and maintain stock and cleanliness.

Education

Bachelor's degree in biology, molecular biology, chemistry, genetics, or related field

Master's degree in biology, molecular biology, chemistry, genetics, or related field

Tools

Lentiviral vector production

Molecular cloning

Plasmid DNA preparation

Job description

University of Colorado Anschutz

Department: Pediatrics – Hematology/Oncology/BMT

Job Title: Intermediate Laboratory ScienceProfessional

Position #: 00823039 – Requisition #: 41203

Job Summary:

This position combines two primary and complementary areas ofresponsibility. First, the individual will serve as a key point ofcontact for the receipt, processing, documentation, and storage ofhuman blood and tissue specimens obtained from clinical areas.These specimens are often unique and non-replaceable; therefore,this work requires sustained focus, meticulous attention to detail,accurate sample identification and labeling, strict adherence toestablished procedures, and timely resolution of any discrepancies.Second, the individual will support CAR T-cell vector developmentthrough molecular biology and vector-production activities,including plasmid DNA preparation, molecular cloning andverification of new CAR constructs, and generation of lentiviralvectors.

Key Responsibilities:

• Collaborate with and support Principal Investigators (PI) andother stakeholders with laboratory and research functions(including clinical research associates and clinicians). Utilize avariety of laboratory techniques required for researchprojects.
• Process peripheral blood and bone marrow to isolate mononuclearcells and serum/plasma.
• Perform plasmid DNA preparations and associated qualityassessment to support ongoing molecular and cellular therapyresearch.
• Perform molecular cloning and verification of new CAR T-cellvector constructs using established recombinant DNAtechniques.
• Generate research-grade lentiviral vectors using establishedlaboratory procedures and maintain accurate batch and productionrecords.
• Perform experiments and tabulate and analyze researchdata.
• Support the analytical testing process using standard labsupport knowledge in the collection and review of conditions,including preserving samples, completing sample preparation,documenting and communicating results.
• Perform pre-analytical, analytical, and post-analytical testprocesses and evaluate results produced.
• Prepare lab for daily operations, including stocking materials,equipment, safety, cleanliness, and related areas.

Work Location:

Onsite – this role is expected to work onsite and is located in Aurora, CO .

Why Join Us:

The University of Colorado Anschutz is a public education,clinical, and research facility serving 4,500 students and is aworld-class medical destination at the forefront of life-changingscience, medicine, and healthcare. CU Anschutz offers more than 42highly rated degree programs through 6 schools and colleges andreceives over $500 million in research awards each year. We are thesingle largest health professions education provider in Colorado,awarding nearly 1,450 degrees annually. Powered by ouraward-winning faculty, renowned researchers, and a reputation foracademic excellence, the CU Anschutz Medical Campus drivesinnovation from the classroom to the laboratory to the delivery ofunparalleled patient care.

Why work for the University?

We have AMAZING benefits and offer exceptional amounts of holiday,vacation, and sick leave! The University of Colorado offers anexcellent benefits package including:

• Medical: Multiple plan options
• Dental: Multiple plan options
• Additional Insurance: Disability, Life, Vision
• Retirement 401(a) Plan: Employer contributes 10% of your grosspay
• Paid Time Off: Accruals over the year
• Vacation Days: 22/year (maximum accrual 352 hours)
• Sick Days: 15/year (unlimited maximum accrual)
• Holiday Days: 15/year
• Tuition Benefit: Employees have access to this benefit on allCU campuses
• ECO Pass: Reduced-rate RTD Bus and light rail service

There are many additional perks & programs with the CU Advantage.

Qualifications:

Minimum Qualifications

• Bachelor's degree in biology, molecular biology, chemistry, genetics, or related field.
  • Substitution: A combination of education and relatedtechnical/paraprofessional experience may be substituted for thebachelor's degree on a year-for-year basis.
• One (1) year of professional-level research experience.

Preferred Qualifications

• Master's degree in biology, molecular biology, chemistry, genetics, or related field.
• Two (2) years of professional-level research experience.
• Experience processing and biobanking human blood and tissuespecimens, including sample aliquoting,preservation/cryopreservation, storage, and inventorymanagement.
• Experience with plasmid DNA preparation, molecular cloning,recombinant DNA methods, and verification of clonedconstructs.
• Experience with lentiviral vector production and mammalian cellculture.
• Experience with laboratory information management systems,biorepository databases, or other structured sample-trackingsystems.

Conditions of Employment:

• Applicants must be legally authorized to work in the UnitedStates without requiring sponsorship. We are unable to provide workvisa sponsorship or employment authorization for this position nowor in the future.
• Must be willing and able to pass national criminal and sexoffender background checks.

Knowledge, Skills, and Abilities:

• Proficient knowledge of basic laboratory techniques, includingsafety procedures and techniques.
• Ability to communicate effectively, both in writing andorally.
• Ability to establish and maintain effective workingrelationships with employees at all levels throughout theinstitution.
• Outstanding customer service skills.
• Knowledge of basic molecular biology and pharmacology.
• Ability to interpret and master complex research protocolinformation.
• Exceptional attention to detail and demonstrated ability tomaintain accurate sample identity, labeling, documentation, andstorage for unique and non-replaceable human specimens.
• Ability to prioritize time-sensitive clinical specimen receiptand processing while concurrently managing scheduled molecularbiology and vector-production workflows.
• Knowledge of human biospecimen processing, aseptic technique,preservation/cryopreservation, biosafety, and sample inventorypractices.
• Proficiency in molecular biology techniques relevant to CART-cell vector development, including plasmid preparation, molecularcloning, construct verification, and lentiviral vectorproduction.

Equal Employment Opportunity Statement:

CU is an Equal Opportunity Employer and complies with allapplicable federal, state, and local laws governingnondiscrimination in employment. We are committed to creating aworkplace where all individuals are treated with respect anddignity, and we encourage individuals from all backgrounds toapply, including protected veterans and individuals withdisabilities.

ADA Statement:

The University will provide reasonable accommodations to applicantswith disabilities throughout the employment application process. Torequest an accommodation pursuant to the Americans withDisabilities Act, please contact the Human Resources ADACoordinator at [e-mail].

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated toensuring a safe and secure environment for our faculty, staff,students, and visitors. To assist in achieving that goal, weconduct background investigations for all prospectiveemployees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19virus and other vaccine preventable diseases. If you work, visit, or volunteerin healthcare facilities or clinics operated by our affiliatedhospital or clinical partners or by CU Anschutz, you will berequired to comply with the vaccination and medical surveillancepolicies of the facilities or clinics where you work, visit, orvolunteer, respectively. In addition, if you work in certainresearch areas or perform certain safety-sensitive job duties, youmust enroll in the occupational health medical surveillance program.

Screening of Applications Begins:

Immediately and continues until five (5) days after the postingdate.

Anticipated Pay Range:

The starting salary range (or hiring range) for thisposition has been established as $52,030 to $69,720 . The above salary range (or hiring range) represents theUniversity's good faith and reasonable estimate of the range ofpossible compensation at the time of posting. This position may beeligible for overtime compensation, depending on the level. Your total compensation goes beyond the number on your paycheck.The University of Colorado provides generous leave, health plans,and retirement contributions that add to your bottom line.

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