Immuno-Oncology Postdoc: PDAC & Spatial Genomics

Mount Sinai Morningside; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Morningside is seeking a Postdoctoral Fellow to join the Department of Immunology and Immunotherapy. The project focuses on pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment using Perturb-map spatial functional genomics to identify genes and pathways that regulate tumor–immune interactions.

The successful candidate will work across molecular biology, genomics, and in vivo cancer models. Ph.D.

Qualifications

• Ph.D. required.
• Experience working in a research laboratory setting.

Responsibilities

• Perturb-map library generation and molecular biology design, clone, and validate perturbations in tumor and tumor-microenvironment cells.
• Culture and genetically manipulate pancreatic cancer cell lines, primary cells, and immune/stromal populations; perform CRISPR screens and functional assays.
• Analyze human pancreatic tumor specimens using spatial transcriptomics and proteomics to validate candidate genes and pathways.
• Conduct in vivo perturbation studies and evaluate therapeutic targets, including immune checkpoint blockade trials.
• Prepare manuscripts and presentations; mentor students and collaborate across teams.

Skills

Research experience

Education

Ph.D.

Job description

Mount Sinai Morningside is seeking a Postdoctoral Fellow to join the Department of Immunology and Immunotherapy. The project focuses on pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment using Perturb-map spatial functional genomics to identify genes and pathways that regulate tumor–immune interactions.

The successful candidate will work across molecular biology, genomics, and in vivo cancer models. Ph.D.