Imaging Science Lead Sr. Principal Scientist

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); On-site; USD 151,000 - 246,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks an Oncology Imaging Scientific Lead to drive strategy and execution of complex early and late phase oncology imaging in clinical trials, with emphasis on PET and CT modalities.

You will lead development of imaging biomarkers, support scientific imaging aspects, and assess tumor response across oncology studies, collaborating with cross-functional teams and external partners.

Qualifications

• Experience in oncology imaging in clinical trials.
• Ability to lead imaging biomarker strategy and study endpoints.
• Experience with regulatory agencies and ethics committees is preferred.

Responsibilities

• Formulate imaging biomarker strategies to inform Regeneron pipeline.
• Lead design and implementation of multimodality imaging endpoints for oncology trials.
• Collaborate with clinical teams to ensure imaging strategy is integrated into study protocols.
• Oversee imaging data quality and analysis, and contribute to study reports.
• Engage with regulatory bodies and ethics committees for approvals.

Skills

Oncology imaging

RECIST 1.1

Imaging biomarkers

Leadership

Regulatory experience

Communication

Clinical trial design

Education

Doctorate in a relevant field

Tools

PET

CT

Job description

Build Our Future Together

The successful candidate will lead the strategy and execution of complex early and late phase oncology imaging in clinical trials where imaging plays a critical role. Imaging includes all modalities with a special focus on PET and CT. In this role, you will lead the development of imaging biomarkers, support the scientific imaging aspects and tumor response assessment of oncology clinical studies. You will be a member of cross-functional program teams including Regeneron clinical and preclinical colleagues as well as external academic and industry partners.

Oncology Imaging Scientific Lead

Clinical Imaging

Build Our Future Together

The successful candidate will lead the strategy and execution of complex early and late phase oncology imaging in clinical trials where imaging plays a critical role. Imaging includes all modalities with a special focus on PET and CT. In this role, you will lead the development of imaging biomarkers, support the scientific imaging aspects and tumor response assessment of oncology clinical studies. You will be a member of cross-functional program teams including Regeneron clinical and preclinical colleagues as well as external academic and industry partners.

This position offers excellent opportunities to develop innovative imaging biomarkers in support of clinical development and to bring treatment options to patients.

When & Where

Locations: Willing to work from one of the following sites:

• Tarrytown, NY
• Warren, NJ
• Cambridge, MA
• Boston, MA

Discover Your Role

• Work closely with imaging, therapeutic area and development leads to formulate appropriate imaging biomarker strategies to inform and advance the Regeneron clinical pipeline.
• Lead, design and implement multimodality imaging measures as endpoints for oncology therapeutic clinical studies.
• Collaborate closely with Regeneron clinical teams as imaging subject matter expert to ensure optimal design and execution of imaging strategy including development of protocols, imaging manuals, imaging charters and statistical analysis plan.
• Work closely with Clinical Imaging Operations and imaging CROs to ensure the flawless conduct and data integrity of study's imaging components and endpoints.
• Serve as Imaging Scientific Lead in clinical trials focused on qualification and utilization of novel imaging biomarkers.
• Lead the interaction with regulatory agencies and site ethic committees for approval of clinical imaging biomarker development studies.
• Design and implement novel PET, immuno-PET and other novel imaging agents/biomarkers in clinical trials.
• Oversee image analysis and interpretation of results, work closely with colleagues to oversee the development of study reports and publications as appropriate.
• Design and implement innovative imaging translational strategies in collaboration with preclinical/clinical research teams and external partners.

This Role Requires

• Experience in the implementation of central efficacy assessment using tumor response criteria such as RECIST 1.1, PCWG3, Lugano and IMWG in oncology clinical trials.
• Leadership experience in the application of imaging as a quantitative endpoint in clinical and preclinical studies with an oncology focus.
• A Doctorate degree in a relevant field, with 5+ years of industry and academic clinical oncology imaging experience.
• Proven excellent written/verbal communication and organization skills.
• Ability to champion imaging innovations and lead projects effectively.
• Preferred: Minimum 5+ years of imaging experience in oncology drug development and clinical PET tracer development in a pharmaceutical/biotechnology setting. Level commensurate with years of experience.
• Preferred: Experience in the application of imaging as a quantitative endpoint in clinical and preclinical studies.
• Preferred: Experience with regulatory agencies and inspections.Preferred: Direct experience with preclinical oncology imaging models using PET and immuno-PET imaging biomarkers.
• Preferred: Strong background in oncology, biology, molecular imaging and familiar with precision medicine approaches.
• Preferred: Imaging CRO oversight and implementation of quality control procedures.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$150,500.00 - $245,500.00