Histotechnician (PM shift, Tues - Sat)

Socket.dev; Fremont (CA); On-site; USD 55,000 - 69,000; Full time

Job summary

Personalis, based in Fremont, California, is seeking a Histotechnician to support our molecular diagnostics offerings by processing FFPE specimens for microscopic evaluation and meeting TAT goals with high-quality productivity.

Requires 3+ years in a high-volume histology lab, HT/HTL ASCP preferred, and experience in IHC and digital imaging with strong documentation practices. NAACLS-accredited histotechnology program or related degree required.

Qualifications

• Associate's degree in chemical/physical/biological science or NAACLS Histotechnology program completed.
• 3+ years in a high-volume histology lab performing microtomy, H&E staining, and embedding.
• Experience in IHC and digital imaging; reading pathology reports a plus.
• Excellent attention to detail, organization, and time management; strong communication.
• Physical ability to lift up to 25 lbs and stand for long periods.

Responsibilities

• Perform sectioning of tissue with a microtome and mount on glass slides.
• Stain tissue sections using automated or manual methods; ensure quality.
• Cover slips on slides, generate digital slide images for review.
• Conduct macrodissection; operate and maintain instruments.
• Follow safety and quality policies; document data in LIMS accurately.
• Meet turnaround time (TAT) goals while maintaining productivity.
• Keep work areas clean and organized; report issues to supervisor.
• Record specimen data and ensure traceability in systems.

Skills

Attention to detail

Time management

Interpersonal skills

Effective communication

Education

Associate's degree in chemical/physical/biological science

NAACLS-accredited Histotechnology program

Bachelor’s degree in a laboratory science (preferred)

Tools

LIMS

Digital imaging

Job description

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Summary: Under the direction of the department supervisor, technical/clinical consultant, and laboratory director, the Histotechnician will be responsible for processing FFPE specimens for microscopic evaluation to support our molecular diagnostics test offerings.

Available Shift: Tuesday - Saturday, 4:00pm - 12:30am

Responsibilities:

• Perform sectioning of tissue using a microtome and mounting on glass slides
• Perform routine staining of tissue sections with automated and/or manual staining techniques
• Perform automated and/or manual coverslipping of slides
• Generate digital slide images for pathologist examination
• Perform manual and automated macrodissection
• Operate and perform instrument maintenance
• Perform histology lab functions while following laboratory safety and quality policies
• Comply with standard laboratory operating policies and procedures
• Use of good documentation practices to record specimen data manually or in Laboratory Information Management Systems
• Help meet TAT goals while maintaining high-quality productivity
• Maintain clean and organized work areas within the laboratory
• Report problems to the department supervisor/manager to ensure timely resolution

Requirements:

• Associate's degree in chemical/physical/biological science or completion of a NAACLS-accredited Histotechnology program; Bachelor’s degree in a laboratory science curriculum preferred
• Minimum of 3+ years experience working in a high-volume histology laboratory performing microtomy of various tissue types, H&E staining, and tissue embedding HT or HTL certification from ASCP preferred
• Experience working in IHC and digital imaging, tissue/tumor identification, and proficiency in reading pathology reports, a plus
• Excellent attention to detail, organization, and time management skills
• Ability to communicate effectively with excellent interpersonal skills
• Physical demands include stooping, turning, bending, squatting, kneeling, and the ability to lift up to 25 lbs.

The hiring range for this position is $40.00 to $50.00 per hour, which may factor in various geographic regions. This shift is eligible for a shift differential pay bonus. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits (For US only, benefits in other countries may vary).

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contact you.