Grad Intern – Target Safety Risk Weighting and Evaluation Strategies (Summer 2027)

1001 Amgen Inc.; Thousand Oaks (CA); Hybrid; USD 49,000 - 57,000; Full time

Job summary

Amgen Inc. in Thousand Oaks, CA is offering a Grad Intern position in Target Safety Risk Weighting and Evaluation Strategies for Summer 2027.

You will design tools to accelerate safety assessments and surface mechanistic insights from omics, preclinical, and clinical data while collaborating with toxicologists and data engineers. Expect to work with Python, R, NLP/LLMs, and AI tools to build risk scoring methods, develop transparent documentation, and present findings to stakeholders.

Qualifications

• Degree in a relevant field and ongoing advanced degree in the specified programs.
• Strong programming in Python and R for data analysis and modeling.
• Experience with AI tools and NLP/Lang Models; familiarity with data integration.
• Experience with omics data, preclinical/clinical data, and literature resources.

Responsibilities

• Use and refine AI tools for data aggregation, processing, interpretation, and automated report generation.
• Integrate multimodal data into risk scoring/weighting methods for safety decisions.
• Generate mechanistic hypotheses and pathway-level safety rationales.
• Write documentation and contribute to codebase for Target Safety Scoring Assessment.
• Present progress to TSRS stakeholders and iterate on tools based on feedback.
• Prioritize use cases with maximum impact in collaboration with TSRS team.

Skills

Python

R

SQL

Git/GitHub

NLP/LLMs

AI tooling

Jupyter

R Markdown

Education

Bachelor’s degree

MBA/Master/PharmD/PhD in progress

Tools

Open Targets

Public biology resources

AWS

Jupyter

Job description

Grad Intern – Target Safety Risk Weighting and Evaluation Strategies (Summer 2027)

What You Will Do Let’s do this. Let’s change the world. During this program, you will help design and integrate tools that accelerate safety assessments from early discovery through post-marketing. You’ll build practical workflows that ingest molecular -omics datasets, clinical adverse event data, and internal data from pre-clinical models to surface mechanistic insights, score/weight potential safety concerns, and support non-clinical safety strategy while working closely with toxicologists, clinical safety scientists, computational biologists, and data engineering partners.

Key Responsibilities:

• Use and refine AI tools for data aggregation, processing, interpretation, and automated report generation across safety workflows
• Integrate multimodal data (public and internal)—including omics, preclinical findings, clinical safety signals, and real-world evidence—into coherent risk scoring/weighting methods to facilitate risk-based decision making
• Generate mechanistic off-target hypotheses and pathway-level safety rationales to support internal safety evaluation strategies
• Write clear documentation (methods, assumptions, limitations) and contribute to codebase for Target Safety Scoring Assessment
• Present progress and findings to TSRS stakeholders; incorporate feedback to iterate on tools and analyses
• Collaborate with TSRS team members to prioritize use cases with maximum impact

What you will gain:

• Real-world impact: Contribute tools that directly inform target safety assessments and decision-making across Amgen programs.
• End-to-end experience: From problem scoping and data ingestion to evaluation, validation, and communication—owning meaningful pieces of the workflow.
• Scientific depth: Exposure to translational safety science, mechanistic biology, real-world datasets, and how multi-omics datasets and literature evidence build risk narratives.
• Mentorship & feedback: Regular guidance from TSRS scientists, data scientists, and engineers; opportunities to present to stakeholders.
• Career readiness: Mentored research experience working within a collaborative, mission-driven team at the intersection of AI and safety sciences.

Program Eligibility Requirements

Must be available to work a full-time schedule. Expected continued enrollment in an accredited college or university following the internship program / co‑op.

Student must be located in the United States for the duration of the internship program.

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. The individual we seek is willing to embrace new challenges, shows enthusiasm for learning and exploring unfamiliar topics, and has these qualifications:

Basic Qualifications:

• Amgen requires that all individuals applying for a grad internship or a co‑op assignment at Amgen must meet the following criteria:
• 18 years or older
• Graduated with a bachelor’s degree from an accredited college or university
• Currently enrolled in an MBA program for an MBA internship OR a Master’s program for a Master’s internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Master’s OR Pharm D OR Ph.D. program before the internship starts

Preferred Qualifications:

• Degree concentration(s) in Toxicology, Computational Biology, Bioinformatics, Computer/Data Science, Life Sciences, or a related field
• Completion of at least 1 year of graduate study by the start of the internship
• Proficiency in Python and R for data analysis and modeling (pandas/NumPy/scikit-learn; tidyverse/Bioconductor).
• Proficiency with AI coding tools (Codex, Claude)
• Experience with Jupyter/R Markdown, SQL, Git/GitHub, and environment management.
• Coursework or hands-on projects in AI/ML; familiarity with NLP/LLMs (prompt engineering, retrieval‑augmented generation, summarization).
• Experience working with -omics datasets and biological knowledge bases/ontologies (e.g., GO, MedDRA, etc.), and public biology resources such as Open Targets or similar.
• Comfort integrating heterogeneous data (e.g. preclinical, clinical, literature) and mapping to pathways/phenotypes.
• Familiarity with target safety assessment, off‑target mechanisms, and translational safety principles
• Familiarity with APIs or simple workflow orchestration; basic cloud literacy (AWS) a plus
• Experience building dashboards or internal utilities (e.g., Shiny) is a plus

What You Can Expect of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $35.34 - $41.20 per hour.

Build a network of colleagues that will endure and grow throughout your time with us and beyond.

Bring your authentic self to the table and become the professional you’re inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.

Participate in executive and social networking events, as well as community volunteer projects.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

Equal Opportunity

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary Range

USD - USD

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Company Overview

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen