Grad Co-op: Advanced Computational Safety for Small Molecules

Amgen; United States; On-site; USD 48,000 - 56,000; Part time

Job summary

Amgen, a global biopharmaceutical leader, invites graduate students to join a Co-op in Computational Safety Modeling for small molecules. You will contribute to expanding our computational toolbox for predicting safety signals early in drug discovery, collaborating with computational scientists and nonclinical safety experts.

You will curate data, develop models, and help integrate experimental results to guide compound prioritization and follow‑up experiments, with opportunities to retrain

Qualifications

• Must be available to work a part‑time schedule.
• Expected continued enrollment in an accredited college or university.
• Student must be located in the United States for the duration of the internship program.

Responsibilities

• Identify, curate, and compare relevant external and internal data, including chemical structures, assay results, and exposure information where available.
• Develop and evaluate approaches suited to each question. These may include structural alerts, analogue-based read‑across, machine learning, and models that integrate experimental results with other safety evidence.
• Evaluate performance on compounds relevant to the intended use, and document context of use, uncertainty, applicability, and important limitations.
• Work with computational scientists, medicinal chemists, and toxicologists to explore how model outputs can guide compound prioritization and follow‑up experiments.
• Present results and deliver reproducible analyses, documented model prototypes, and recommendations for further development.
• Provide mechanisms for retraining as additional data is generated over time

Skills

Python for data analysis

Statistical modeling & ML

Documentation of reproducible workflows

Communication across disciplines

Cheminformatics / predictive toxicolog

Version control familiarity

Education

Bachelor's degree

MBA internship

Master’s internship

PharmD internship

PhD internship

Tools

Git

R

Jupyter

Job description

Amgen, a global biopharmaceutical leader, invites graduate students to join a Co-op in Computational Safety Modeling for small molecules. You will contribute to expanding our computational toolbox for predicting safety signals early in drug discovery, collaborating with computational scientists and nonclinical safety experts.

You will curate data, develop models, and help integrate experimental results to guide compound prioritization and follow‑up experiments, with opportunities to retrain