GMP Technician I, Upstream

Forge Biologics

Columbus (OH)

On-site

USD 42,000 - 62,000

Full time

2 days ago

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Benefits offered by this job

Health insurance

Paid time off

Annual bonus opportunities

401(k) with company match

Onsite fitness facility

Job summary

Forge Biologics is seeking a Technician I, GMP Manufacturing — Upstream to contribute to the production of AAV-based gene therapy products in a cGMP environment. You will operate bioreactors and related equipment, perform cell culture steps, and ensure strict adherence to SOPs and batch records.

The role involves collaboration with QA/QC, documentation of processes, and participation in process improvements to enhance productivity while maintaining high quality and safety standards.

Qualifications

Experience in a regulated manufacturing or lab environment.
Ability to multitask in a fast-paced setting while following timelines.
Commitment to SOPs, safety, and regulatory guidelines.

Responsibilities

Execute upstream manufacturing operations per SOPs and batch records.
Prepare and operate bioreactors, centrifuges, and filtration systems.
Perform media and buffer prep and aseptic transfer of materials.
Monitor process parameters and report deviations to supervisor.
Document activities and results in compliance with cGMP.

Skills

Strong problem-solving

Clear communication

Multitasking

Team collaboration

SOP adherence

Education

Associate’s or Bachelor’s degree in a scientific field

High school diploma + 2 years related experience

Tools

Bioreactors

Centrifuges

Filtration systems

Job description

At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities — all united by one goal: improving lives. If you’re driven by purpose and excited to make a tangible impact, this is where your journey begins.

Our team works out of The Hearth, a state‑of‑the‑art, 200,000-square‑foot cGMP facility in Columbus, Ohio. Here, you won’t just watch innovation happen — you’ll be part of it. Whether you’re scaling AAV manufacturing, collaborating on cutting‑edge therapies, or supporting complex technical projects, you’ll play a key role in bringing hope to patients with genetic diseases.

What sets Forge apart is our culture ofH.O.P.E.We arehardworking, showing up each day with determination and grit. We areopen, creating a space where ideas flow freely, and every voice is valued. We arepurpose‑driven, with every task directly tied to changing lives. And we areengaged, energized by the challenges we face and the milestones we achieve together.

At Forge, your growth matters. We’re committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands‑on learning, and opportunities for advancement. Our people are our greatest investment, and we’re proud to see team members grow with us.

If you’re ready to use your talent to help deliver hope to patients around the world, join us — and be part of something bigger than yourself.

About The Role:

The Technician I, GMP Manufacturing – Upstream will play a c ritical role in the production and cultivation of AAV‑based gene therapy products in compliance with current Good Manufacturing Practices (cGMP) regulations. This position offers an exciting opportunity to contribute to the development and manufacturing of cutting‑edge therapies that have the potential to transform the lives of patients.

Responsibilities:

Execute upstream manufacturing operations, including but not limited to cell culture expansion, transfection, and harvest steps, according to Standard Operating Procedures (SOPs) and batch records.
Prepare and operate bioreactors, centrifuges, filtration systems, and other equipment required for upstream processing, ensuring they are properly calibrated and maintained.
Perform media and buffer preparation, as well as the aseptic transfer of materials, adhering to cGMP guidelines and maintaining a clean and organized work area.
Monitor critical process parameters during manufacturing operations and report any deviations or abnormalities to the supervisor in a timely manner.
Conduct sampling and in‑process testing, such as cell counts, viability, and metabolite analysis, to ensure optimal culture conditions and product quality.
Document all manufacturing activities, data, and results accurately and in compliance with cGMP regulations and company policies.
Collaborate with cross‑functional teams, including Quality Assurance (QA) and Quality Control (QC), to investigate and resolve deviations, non‑conformances, and quality incidents related to upstream manufacturing processes.
Participate in process improvement initiatives and support the implementation of new technologies, equipment, and methods to enhance manufacturing efficiency and productivity.
Follow safety procedures and adhere to environmental health and safety guidelines to maintain a safe working environment.
Participate in training programs and stay updated with current industry trends, regulatory requirements, and advancements in gene therapy manufacturing processes.

Qualifications:

Associate’s or Bachelor’s degree in a scientific field, or relevant industry certifications; or high school diploma with +2 years of related experience.
Previous experience working in a regulated manufacturing or laboratory environment.
Excellent organizational skills and the ability to multitask in a fast‑paced environment while adhering to strict timelines.
Good interpersonal and communication skills, both written and verbal, to effectively collaborate with team members and stakeholders.
Commitment to following SOPs, safety protocols, and regulatory guidelines to ensure compliance and product quality.
Strong problem‑solving skills and ability to identify and elevate issues as needed.
Ability to adapt to changing priorities and work independently as well as part of a team.
Flexibility to work in shifts, including weekends and holidays, as required by manufacturing production schedules.
Ability to stand for extended periods, and work in a cleanroom environment while wearing appropriate gowning and PPE.

Preferred Skills:

Prior experience working in a cGMP manufacturing environment.
Upstream bioprocessing or biologics manufacturing experience.
Familiarity with cell culture techniques, bioreactors, centrifuges, and filtration systems
Basic understanding of viral vector‑based gene therapy processes, principles, and quality requirements.

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change, or new ones may be assigned.

Work Environment and Physical Demands

This position is performed in a temperature‑controlled laboratory or office environment and requires regular standing, hand manipulation, and use of laboratory equipment. The role may involve lifting or moving materials up to 25 pounds and occasional reaching or handling at various heights. Appropriate personal protective equipment (PPE) must be worn when working with chemicals, biological materials, or in controlled environments.

Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

At Forge Biologics, we believe our people deserve to be taken care of – in and out of the workplace. We’ve built a comprehensive compensation and benefits package designed to help you thrive, grow, and feel valued every step of the way:

Health from day one

Health, dental and vision insurance start your first day – with 90% of premiums covered for youandyour family.

Time to recharge

A competitive paid time off plan – because rest fuels innovation.
12 weeks of fully paid parental leave so you can focus on family when it matters most.

Rewarding your impact

Annual bonus opportunities for all full‑time team members.
401(k) with company match to help you plan for the future.
Special employee discounts, including childcare and dependent care savings.
Onsite fitness facility at The Hearth.
Mental health counseling and financial planning services through our Employee Assistance Program.
Employer‑paid short and long‑term disability coverage to protect your peace of mind.

Fuel for your workday