Functional Genomics Scientist III

Astrix Technology; Ridgefield (CT); On-site; USD 65,000 - 68,000; Full time

Job summary

Astrix Technology is seeking a Functional Genomics Scientist III in Ridgefield, Connecticut to design and execute advanced functional genomics assays, including CRISPR genome editing and single-cell sequencing.

The role requires hands-on experience with NGS library prep, data QC, and collaboration across teams. This 1-year contract position offers opportunities to contribute to cutting-edge projects in a global pharmaceutical setting.

Qualifications

• Master's degree in Molecular Biology, Cell Biology, Functional Genomics, or a related field with 4+ years of hands-on laboratory experience.
• Proven experience with CRISPR genome editing, including guide RNA design, transfection/infection, edited cell selection, and knockout/knock-in validation.
• Hands-on experience with next-generation sequencing (NGS) library preparation.
• Experience with single-cell technologies, including sample preparation, library generation, and quality control.
• Proficiency in molecular biology techniques such as qPCR, Western blotting, cloning, and gel electrophoresis.
• Strong cell culture skills, including maintaining multiple cell lines and performing transfections using sterile technique.
• Ability to troubleshoot functional genomics experiments and work effectively in a collaborative, multidisciplinary environment.
• Experience with lab automation and handling multiple experimental workflows simultaneously is a plus.

Responsibilities

• Design, develop, and execute functional genomics assays, including CRISPR-based genome editing workflows.
• Perform CRISPR experiments including guide RNA design, RNP delivery, transfection/infection, selection of edited cells, and validation of knockouts/knock-ins.
• Conduct next-generation sequencing (NGS) library preparation for genomics and transcriptomics applications.
• Perform single-cell sequencing workflows, including sample preparation, library generation, and quality control.
• Implement and support advanced assays such as Perturb-seq, CITE-seq, and spatial transcriptomics.
• Maintain accurate and detailed laboratory documentation in compliance with internal policies.
• Define and execute quality control (QC) procedures to ensure data reliability and reproducibility.
• Operate, maintain, and troubleshoot laboratory equipment.
• Provide technical guidance and training to research scientists on functional genomics technologies.
• Monitor scientific literature to identify new methods, tools, and best practices in functional genomics.

Skills

CRISPR editing

NGS library prep

Single-cell tech

Molecular biology

Cell culture

Troubleshooting

Lab automation

Education

Master's degree in Molecular Biology or related

Tools

qPCR

Western blotting

Cloning

Gel electrophoresis

Job description

Functional Genomics Scientist III

Science & Research

Ridgefield, Connecticut, US

• Added - 05/05/2026

Pay Rate Low: 47 | Pay Rate High: 49

Our client, a leading global pharmaceutical company, is looking for a skilled Functional Genomics Scientist III to join their team in Fairfield County, CT! This is a great opportunity to join a leading pharmaceutical company!

Job Type: 1 year contract

Pay rate: $47/hr. - $49/hr.

Location: Fairfield County, CT

Position Summary

We are seeking a highly motivated Functional Genomics Scientist III with strong experience in molecular and cell biology to design, develop, and execute advanced functional genomics assays. The ideal candidate will have hands-on expertise in CRISPR-based genome editing, next-generation sequencing library preparation, and single-cell technologies.

Key Responsibilities

• Design, develop, and execute functional genomics assays, including CRISPR-based genome editing workflows.
• Perform CRISPR experiments including guide RNA design, RNP delivery, transfection/infection, selection of edited cells, and validation of knockouts/knock-ins.
• Conduct next-generation sequencing (NGS) library preparation for genomics and transcriptomics applications.
• Perform single-cell sequencing workflows, including sample preparation, library generation, and quality control.
• Implement and support advanced assays such as Perturb-seq, CITE-seq, and spatial transcriptomics.
• Maintain accurate and detailed laboratory documentation in compliance with internal policies.
• Define and execute quality control (QC) procedures to ensure data reliability and reproducibility.
• Operate, maintain, and troubleshoot laboratory equipment.
• Provide technical guidance and training to research scientists on functional genomics technologies.
• Monitor scientific literature to identify new methods, tools, and best practices in functional genomics.

Required Qualifications

• Master's degree in Molecular Biology, Cell Biology, Functional Genomics, or a related field with 4+ years of hands-on laboratory experience.
• Proven experience with CRISPR genome editing, including guide RNA design, transfection/infection, edited cell selection, and knockout/knock-in validation.
• Hands-on experience with next-generation sequencing (NGS) library preparation.
• Experience with single-cell technologies, including sample preparation, library generation, and quality control.
• Proficiency in molecular biology techniques such as qPCR, Western blotting, cloning, and gel electrophoresis.
• Strong cell culture skills, including maintaining multiple cell lines and performing transfections using sterile technique.
• Ability to troubleshoot functional genomics experiments and work effectively in a collaborative, multidisciplinary environment.
• Experience with lab automation and handling multiple experimental workflows simultaneously is a plus.

*This job description is a complete list of all desired skills, but not all are required. We strongly encourage candidates who have some of the skills to apply. We look forward to a conversation to learn more about you! *

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We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.