Founding Systems Engineer — AI‑Native HPC for Drugs

10x Science (YC W26); San Francisco (CA); On-site; USD 150,000 - 240,000; Full time

Benefits offered by this job

401(k) plan

Equity options

Job summary

10x Science, based in San Francisco, is looking for a founding engineer to contribute to a high-performance computing platform for AI-powered drug discovery. You'll join a small team and work directly with the founders, taking on significant responsibilities from day one. Ideal candidates excel in low-level system architecture and possess strong problem-solving skills. Compensation includes a competitive salary of $150,000 to $240,000, equity, and benefits as part of a pioneering team dedicated to making impactful contributions in the pharmaceutical industry.

Qualifications

• Strong fundamentals in systems programming, algorithms, and data structures.
• Experience building software that has to be fast.
• Comfortable taking ill-defined problems and shipping solutions.
• Desire to work in a fast-paced startup environment.
• Intellectual curiosity about hard technical problems.

Responsibilities

• Build and own core modules of a high-performance scientific computing platform.
• Architect systems for throughput and correctness across large datasets.
• Work directly with the founding team to translate scientific knowledge into software.
• Deploy to enterprise customers and iterate based on real-world feedback.
• Make foundational technical decisions that define the platform.

Skills

Low-level systems architecture

Compute-performance tradeoffs

Obsessed with interpretability

Leverage tools

Rapid learning ability

Job description

10x Science, based in San Francisco, is looking for a founding engineer to contribute to a high-performance computing platform for AI-powered drug discovery. You'll join a small team and work directly with the founders, taking on significant responsibilities from day one. Ideal candidates excel in low-level system architecture and possess strong problem-solving skills. Compensation includes a competitive salary of $150,000 to $240,000, equity, and benefits as part of a pioneering team dedicated to making impactful contributions in the pharmaceutical industry.