Executive Medical Director, Clinical Development Lead - Oncology GU

GSK; Upper Providence (Delaware County); On-site; USD 147,000 - 240,000; Full time

Job summary

GSK in the UK is seeking a Clinical Development Lead (CDL) for Oncology GU to define the clinical strategy and scientific narrative across the asset lifecycle. You will partner with the MDT core quad to shape governance, investment decisions, and development speed, leveraging AI-enhanced insights.

The role will be based at Stevenage temporarily before relocation to Cambridge, expected by early 2029, with responsibility for strategic direction, cross-functional collaboration, and talent

Job description

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most - advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

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Our approach to R&D

With GSK's growing portfolio in GU (genitourinary) cancers, we have an exciting opportunity for a Clinical Development Lead (CDL) - Oncology GU. Operating at the asset level as the enterprise clinical strategy leader, you will be accountable for defining the clinical strategy, scientific narrative, and decision framework across the asset lifecycle. The CDL serves as a full strategic partner within the Medicine Development Team (MDT) core quad, positioning Clinical Development at the centre of product strategy, governance, and investment decisions.

The CDL owns the clinical roadmap and serves as the recognised clinical authority and visible leader for the asset's strategic vision, shaping how clinical strategy, scientific insight, development innovation, and decision velocity are understood and experienced across the organisation, representing Clinical Development in both internal and external settings. You will be accountable for the strategic direction and clinical positioning of the asset, with operational study-level delivery led by Senior Scientists within the programme. This role is critical to enabling a more dynamic, data-driven, and technology-enabled model of clinical development, increasing speed, precision, and decision quality.

In This Role You Will:

• Define and own the clinical strategy, scientific narrative, integrated benefit-risk position, and decision framework across the asset, ensuring a coherent and differentiated clinical position throughout the lifecycle
• Accountable for strategic outcomes across the asset, with study-level delivery, including design, execution, and data generation, led by Senior Scientists and programme teams within the CDL's strategic direction
• Serve as the senior clinical strategy leader on the MDT core quad, acting as a full strategic partner to the Medicine Development Leader (MDL) and representing Clinical Development in portfolio, governance, and investment decisions
• Lead or co-lead governance and investment presentations to senior management, translating clinical evidence into clear strategic recommendations for portfolio prioritisation and progression
• Serve as the recognised clinical authority and visible leader for the asset, ensuring its clinical vision, scientific identity, and development trajectory are clearly understood and advanced across the organisation
• Drive an integrated, end-in-mind approach to development, ensuring that target selection, development pathways, regulatory positioning, and commercial readiness are considered as a connected whole
• Act as the default Clinical Development representative for Health Authority interactions, advisory boards, steering committees, IDMCs, and alliance partnerships
• Leverage AI-enabled insights, advanced analytics, and emerging data platforms to inform asset-level strategic decisions and drive competitive advantage in development speed and decision quality
• Lead, develop, and mentor clinical development talent, contributing to talent calibration, succession planning, and capability building aligned to evolving development models

Key Responsibilities:

Enterprise Clinical Strategy and Governance

• Serve as the senior clinical strategy leader on the MDT core quad, representing the voice of Clinical Development in portfolio, governance, and investment decisions
• Own the clinical and scientific narrative for the asset, acting as the recognised clinical authority whose leadership is synonymous with the asset's clinical vision and development trajectory
• Lead or co-lead governance and investment discussions, translating clinical evidence and benefit-risk into strategic recommendations that inform portfolio prioritisation and resource allocation
• Drive an integrated, end-in-mind approach to clinical strategy, moving beyond sequential development to ensure alignment across scientific, regulatory, and commercial considerations
• Proactively engage enterprise stakeholders - including Medical Affairs, Integrated Evidence, Commercial, and Regulatory - to integrate perspectives, resolve trade-offs, and align on product strategy
• Define the asset-l