Executive Director, Medical Science

Adlai Nortye; United States; On-site; USD 250,000 - 320,000; Full time

Job summary

Adlai Nortye seeks an Executive Director, Medical Science to lead the medical execution of oncology clinical trials. This physician‑scientist role focuses on hands‑on protocol development, safety review, and data interpretation across Phase 1 to Phase 3 trials.

You will serve as the core medical expert for the oncology portfolio, ensuring scientific integrity while collaborating with operations and regulatory teams.

Qualifications

• MD or PhD in a relevant biomedical field.
• Minimum of 15 years of progressive experience in pharma/biotech, Oncology.
• Hands-on experience managing clinical trials across early and late-phase settings.
• Operational agility and ownership of deliverables.

Responsibilities

• Draft and refine clinical protocols, IBs, and CSRs; author or review key medical documents.
• Provide direct medical monitoring across Phase 1–3 oncology trials; assess AEs/SAEs and site queries.
• Analyze clinical data to identify trends, efficacy signals, and safety issues; prepare data summaries and visuals.
• Collaborate with Biostatistics, Clinical Operations, and Regulatory teams to solve challenges.

Skills

Clinical trial conduct

Medical writing

Data analysis & interpretation

Cross-functional collaboration

KOL/site engagement

Communication

Education

MD or PhD in biomedical field

Job description

We are seeking a dedicated and clinically grounded Executive Director, Medical Science to join our Oncology team. This is a highly active, hands-on role for a physician-scientist who thrives on diving deep into the data and driving the medical execution of our clinical trials.

You will serve as the core medical expert for our oncology portfolio, covering the full lifecycle from Phase 1 first-in-human studies to Phase 3 registrational trials. Unlike purely administrative roles, you will be directly responsible for the day-to-day medical deliverables, including protocol development, safety review, and data interpretation. You will work closely with the clinical operations team to ensure the scientific integrity of our studies while maintaining a "roll-up-your-sleeves" approach to problem-solving.

Key Responsibilities:

• Hands-on Clinical Execution: Actively participate in the drafting and refinement of clinical protocols, investigator brochures (IBs), and clinical study reports (CSRs). You will be the primary author or key reviewer for critical medical documents.
• Full Lifecycle Medical Oversight: Provide direct medical monitoring for ongoing Phase 1-3 oncology trials. This includes reviewing patient narratives, assessing adverse events (AEs/SAEs) for causality, and responding to site medical queries in real-time.
• Data Analysis & Interpretation: Dive deep into clinical datasets to identify trends, efficacy signals, and safety issues. Prepare data summaries and visualizations for internal team meetings and external presentations.
• Cross-functional Collaboration: Work side-by-side with Biostatistics, Clinical Operations, and Regulatory teams to solve operational challenges. Translate complex medical concepts into actionable plans for non-medical team members.
• KOL & Site Engagement: Serve as the primary scientific contact for investigators and Key Opinion Leaders. Conduct site initiation visits (SIVs) or investigator meetings as needed to explain the scientific rationale and protocol nuances.
• Literature & Competitive Intelligence: Conduct regular reviews of current oncology literature and competitor data to ensure our clinical strategy remains scientifically robust and up-to-date.

Qualifications:

Education: MD, or PhD in a relevant biomedical field.

Experience: Minimum of 15 years of progressive experience in the pharmaceutical or biotechnology industry, specifically within Oncology.

Full Lifecycle Expertise: Demonstrated hands‑on experience managing clinical trials across early-phase (Phase 1/1b) and late-phase (Phase 2/3) settings. You must be comfortable switching between dose‑finding studies and large‑scale registrational trials.

Operational Agility: Proven ability to handle high‑volume medical tasks independently. You are a "doer" who takes ownership of deliverables rather than just delegating them.

Scientific Acumen: Strong understanding of oncology disease biology, standard of care, and endpoint selection. Ability to critically evaluate complex clinical data.

Communication: Excellent written and verbal communication skills, with the ability to write clear, concise medical documents and present data effectively.

Adaptability: Experience working in a fast‑paced, entrepreneurial environment where wearing multiple hats is required.