Executive Director, Clinical Business Operations

BeOne Medicines Ltd.; San Mateo (CA); On-site; USD 200,000 - 320,000; Full time

Job summary

BeOne Medicines Ltd. in California seeks a global operational strategy and governance leader to drive excellence in Clinical Business Operations, with accountability for budgets, site contracts, and payments, ensuring forecast accuracy and audit readiness.

The role leads a high-performing, cross-functional team, advances digital transformation initiatives, and partners with Corporate Finance to optimize financial governance and resource allocation.

Qualifications

• Bachelor’s degree or above in a relevant field.
• 14+ years of experience in Clinical operations, or study start-up, clinical site budgets, clinical site contracts.
• Experience in a pharmaceutical sponsor or CRO environment.
• Strong planning and organizational skills and ability to lead a team in a dynamic environment.

Responsibilities

• Align regional execution strategies with global governance frameworks and clear accountability.
• Establish recurring governance cadences and executive reporting for risk and performance.
• Own and monitor KPIs across investigator budgeting, site contracting, payments, and data governance.
• Oversee development, review, negotiation, and timely execution of site budgets and clinical trial agreements.
• Supervise end-to-end site payment processes and reconciliation to contractual terms.

Skills

Strategic leadership

Cross-functional collaboration

Executive communication

Budget forecasting

Process improvement

Education

Bachelor's degree or above in Life Sciences/Finance/Health Economics or related fields

Tools

Microsoft Office

Power BI

CTMS

Veeva

Contract Lifecycle Management System

Job description

General Description:

• As a global operational strategy and governance leader, drive operational excellence, financial stewardship, compliance, scalability, and digital transformation initiatives across Clinical Business Operations team.

• Oversee investigator budgets, site contracts, site payments, and budget data hub team to ensure precise budget forecasting, efficient site contract execution, timely and accurate site payments and budget data entry in databases.

• Responsible for CBO workforce planning, talent acquisition, succession planning, capability development, performance management, and fostering a high-performing, agile, and continuously improving team.

Essential Functions of the Job:

• Ensure alignment of regional execution strategies with global governance frameworks, including clear accountability models, decision-making processes, and issue escalation mechanisms across cross-functional and cross-country stakeholders.

• Establish and lead recurring governance cadences, including quarterly business reviews, escalation forums, and executive reporting to ensure risks, trends, and operational performance are proactively managed and communicated.

• Own and monitor key operational and financial performance indicators (KPIs) across investigator budgeting, site contracting, payments, and budget data governance functions, including but not limited to:

• Site contract cycle time and execution timeliness

• Budget forecast accuracy and forecast vs. actual variance

• Site payment timeliness and reconciliation accuracy

• Provide strategic oversight of investigator fee budget planning activities to support accurate financial forecasting.

• Direct the development, review, negotiation, and timely execution of site budgets and clinical trial agreements in alignment within Fair Market value principles, study requirements, company standards, and study start-up timelines to support efficient operational delivery.

• Supervise the end-to-end site payment process and payment reconciliation process to ensure financial obligations are processed accurately and in accordance with contractual terms and payment schedules.

• Oversee the collection, validation, and maintenance of budget-related information within designated databases and systems to support data integrity and accuracy.

• Ensure all budget, contract, payment, and supporting operational documentation remains audit ready and compliant with applicable regulatory, financial, and internal governance standards.

• Maintain oversight of Sunshine reporting obligations and global transparency requirements, ensuring appropriate processes, controls and stakeholder alignment are consistently implemented across regions.

• Provide strategic oversight of outsourced vendors and external business partners, including performance monitoring, service quality oversight, issue escalation, and governance.

• Establish strong partnerships with Corporate Finance to drive financial governance, including oversight of accruals, forecast versus actual, and reconciliation processes.

• Oversee operational finances and team resources to ensure activities remain within approved budgets and resource allocations.

• Provide leadership, guidance, and performance management to team members, fostering accountability, collaboration, and continuous improvement.

• Support implementation of automation tools and digital solutions to improve overall productivity.

Supervisory Responsibilities:

• Yes

Computer Skills:

• MicrosoftOfficeapps,PowerBI,orequivalent,CTMS,ContractLifecycle Management System,Veeva,Sharepoint etc.

Education Required:

• Bachelor’sdegree or above, inLifeSciences, Medical Science/ Medical, Finance, Health Economics, or relatedfields.

• 14+ yearsof experience in Clinical operations, orstudy start-up, clinical site budgets,clinicalsitecontracts,within a pharmaceutical sponsor or CRO environment.

• 20+ years of experience preferred.

Other Qualifications:

• Strongplanningandorganizationalskillsandtheabilitytoeffectively leading teaminadynamicenvironment withcompeting priorities.

• Strongexecutivecommunicationskillswithabilitytopresentdata-driven insights to Senior leadership.

• Solution-driven and results-focused, with a willingness to dive deep and take a hands-on approach to work.

• Demonstratedabilitytoanalyzecomplexfinancialdataandtranslate insightsintoactionableguidance.

• Experienceworkingcross-functionallywithClinicalOperations,Finance, Payments, and Legal stakeholders.

• AdvancedproficiencyinExcelanddataanalyticstools;experiencewith budgetsystemsandcontractlifecyclemanagementplatformspreferred.

• GoodknowledgeofICH-GCP,pharmaceuticalrelatedregulationsandlaws.

Travel:

• Yes,10%

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.