Engineer, Process Sciences – Upstream

Encodedgenomics; Morrisville (NC); On-site; USD 90,000 - 120,000; Full time

Job summary

Encoded Therapeutics in North Carolina is seeking an Engineer, Process Sciences – Upstream to join our Internal Manufacturing group. You will design, execute, and analyze small-scale studies to support our AAV-based pipeline.

You will participate in upstream manufacturing for pre-clinical and clinical programs, assist with technology transfer to GMP facilities, and collaborate across teams to meet project timelines and quality standards.

Qualifications

• BS or MS in a relevant field such as biochemical/chemical engineering, biology or biochemistry.
• At least 3 years of industry experience or equivalent educational experience.
• Experience in MSAT/PD/Process Sciences is preferred.

Responsibilities

• Design, execute, and analyze small-scale studies supporting upstream development.
• Fabricate and support pre-clinical and clinical manufacturing for AAV projects.
• Facilitate technology transfer of manufacturing processes to GMP and non-GMP sites.
• Provide on-site support for GMP manufacturing at internal and external sites.
• Collaborate with cross-functional teams to support tech transfer and timelines.

Skills

Cell culture

cGMP knowledge

Project timelines

Communication skills

Team collaboration

Education

BS or MS in biochemical/chemical engineering, biological sciences, virology, molecular biology, or biochemistry

Job description

Engineer, Process Sciences – Upstream

Department:

Internal Manufacturing

Locations:

Type:

Full time

Encoded Therapeutics is a clinical-stage genetic medicines company developing potentially disease-modifying therapies to improve the lives of people with severe CNS disorders. Our proprietary vector engineering approach combines novel regulatory elements and payloads with AAV vectors to unlock innovative solutions for debilitating, intractable CNS conditions. At the forefront is our flagship clinical program, ETX101 for Dravet syndrome, which targets the underlying cause of the disorder to enable highly selective upregulation ofSCN1Afor potentially long-lasting benefit. In parallel, we are advancing a pipeline of potentially best-in-class programs to address significant unmet needs across both monogenic and prevalent CNS conditions. For more information, please visitwww.encoded.com .

We are recruiting an Engineer, Process Sciences to join our team. This is a unique opportunity to work at the intersection of genomics and therapeutics and participate in the development of a diverse therapeutic pipeline driven by a transformative core technology. The successful candidate will work well across multiple projects in a fast-paced and dynamic environment.

Responsibilities

• Design, execute, and analyze small-scale studies supporting the development of two at-scale products and Encoded's pipeline products
• Serve as an engineer responsible for pre-clinical and clinical manufacturing for AAV projects and plasmid manufacturing; including upstream, downstream, fill finish, and drug device
• Facilitate Encoded's technology transfer of manufacturing processes to non-GMP/GMP internal and external sites of manufacturing
• Provide person-in-plant support of GMP (clinical and commercial) manufacturing as required at internal and external sites of manufacturing
• Work with cross-functional teams to develop tools/templates to support tech transfer business processes

Requirements

• B.S or M.S. in a relevant area of specialization (biochemical engineering, chemical engineering, biological sciences, virology, molecular biology, or biochemistry)
• At least 3 years of industry experience or equivalent educational experience
• At least 1 year of industry experience in MSAT/PD/Process Sciences role preferred
• Extensive working knowledge of modern laboratory procedures and knowledge of cGMP is a must
• Ability to independently design, execute, and analyze small-scale cell culture studies (cell expansion, single-use bioreactors, and harvest/clarification) is a must
• Must be a team player and exhibit a willingness to meet project timelines
• Strong verbal and written skills are required as well as effective interpersonal, technical, and troubleshooting skills
• Outstanding planning, organization, and multitasking skills
• Experience with gene therapy processes is strongly preferred
• Comprehensive benefits package, including competitive employer premium contributions
• PTO, sick time, and holiday pay
• Generous Parental Leave program
• Pre-tax medical and dependent care programs
• STD, LTD, Life and AD&D
• Team-building events
• Stocked micro-kitchen with drinks and snacks
• Wellness Resources

Encoded is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Encoded is committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. Encoded will not tolerate discrimination or harassment based on any of these characteristics. Encoded encourages applicants of all ages.