Engineer II, Kilo Lab and Process Safety

Takeda; Boston (MA); On-site; USD 72,000 - 113,000; Full time

Job summary

Takeda seeks an Engineer II, Kilo Lab and Process Safety in Boston to lead process safety workflows and develop data-driven safety strategies. You will manage safety data, collaborate with chemists and engineers, and enable safe scale-up of pharmaceutical processes across R&D and manufacturing facilities.

The role emphasizes modeling safety parameters, maintaining kilo labs, and coordinating with vendors and stakeholders to ensure compliant, efficient operation within Takeda’s SMPD group.

Qualifications

• Associates degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; 2+ years of industry experience.
• Bachelor's degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; some relevant industry experience preferred.
• Prior lab or pilot plant experience is preferred.
• Experience in process safety within pharmaceutical, agrochemical, or related industries is a plus.
• Experience with process safety prediction software (e.g., AKTS, Aspen Plus, gPROMS) is a plus.
• Familiarity with FAIR data principles (Findable, Accessible, Interoperable, Reusable) to enable data management for safety modeling.

Responsibilities

• Support phase appropriate process safety testing.
• Collaborate with process chemists and engineers to evaluate hazards for safe scale-up of pharmaceutical processes.
• Collect and integrate process safety data and ensure data compliance with FAIR principles.
• Partner with external vendors for process safety data collection.
• Document safety results in ELN and generate digital safety reports for cross-functional use.
• Model and predict parameters like SADT and TMRad to drive safety interventions.
• Maintain kilo labs to ensure a safe, clean, and functional workspace.
• Manage kilo lab inventory and coordinate with contractors and internal stakeholders for installation and qualification of equipment.
• Oversee internal manufacturing campaigns and support equipment setup, execution, and cleaning.

Skills

Process safety

Data-driven decisions

Lab/Pilot plant experience

Education

Associates degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science

Bachelor's degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science

Tools

DSC

ARC

EasyMax

RC-1

TSU

AKTS

Aspen Plus

gPROMS

Job description

Job Description

Join Takeda as an Engineer II, Kilo Lab and Process Safety. As part of the SMPD - Process Engineering & Technology team, you will report to the Associate Director of Process Engineering. As the Engineer II, Process Safety you will take charge of cutting-edge process safety workflows and evaluations, ensuring that the latest technologies are leveraged at every stage of process research, development, and manufacturing. They will be responsible for reducing process risks and enabling a safer, smarter, and faster development Additionally, the Engineer II will help build and maintain SMPD’s process safety database while championing an in-silico first mindset to minimize experimentation and promote data-driven decisions.

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide. The Process Development, Engineer II is responsible for performing engineering operations within the organization, focusing on designing, constructing, testing, and operating equipment. This role ensures standards of quality, cost, safety, reliability, timeliness, and performance are met in production processes, contributing to Takeda’s mission of bringing better health to people and a brighter future to the world.

How you will contribute:

• Support phase appropriate process safety testing.


• Work with process chemists and engineers to perform a thorough evaluation of all known and potential hazards for the safe scale-up of chemical processes for preparing pharmaceutical intermediates and active pharmaceutical ingredients in Takeda's research and manufacturing facilities.


• Collect and integrate relevant process safety data (e.g., calorimetry, pressure build-up, off-gassing), using for e.g. DSC, ARC, TSU, EasyMax, RC-1 and ARC into digital platforms for seamless data analysis and sharing, ensuring data complies with FAIR principles (Findable, Accessible, Interoperable, Reusable).


• Work with external vendors to collect relevant process safety data.


• Document and summarize safety results in an Electronic Lab Notebook (ELN) and generate comprehensive digital process safety reports, ensuring consistent and accessible data tracking and compliance documentation. Partner with internal & external manufacturing organizations to ensure the safe scale-up of Takeda’s processes.


• Use software and build models to calculate critical process parameters, such as runaway reactions, self-accelerating decomposition temperature (SADT), and time to maximum rate under adiabatic conditions (TMRad), driving proactive safety interventions.


• Maintain SMPD’s kilo labs, ensuring that they are safe, clean and functional.


• Manage the kilo lab inventory (including chemicals, reagents, equipment & consumables) and ensure adequate supplies are available.


• Coordinate with contractors, vendors, and internal stakeholders to oversee the installation, commissioning, and qualification of kilo lab equipment and systems.


• Oversee internal manufacturing campaigns (e.g. reviews batch records, set-up equipment, support execution & cleaning).


• Support local initiatives as directed by his/her supervisor and participate in global functional initiatives as appropriate.

What you bring to Takeda:

• Associates degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science and 2+ years relevant industry experience


• Bachelors degree in chemistry, biology, pharmacy, engineering or related pharmaceutical science; some relevant industry experience preferred


• Previous experience working in a lab setting preferred.


• Previous experience working in a pilot plant setting a plus.


• Previous experience in process safety in the pharmaceutical, agrochemical, fine chemical or related industry a plus.


• Experience using relevant process safety equipment (e.g. DSC, RC1, Easymax HFCal, ARC, Tsu) a plus.


• Previous experience with software packages for process safety prediction (e.g., AKTS, Aspen Plus, gPROMS) a plus, focusing on the prediction of thermal, chemical, and kinetic properties.


• Understanding of FAIR data principles (Findable, Accessible, Interoperable, Reusable) to drive efficient data management for safety modeling and analytics.

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

For Location:

Boston, MA

U.S. Base Salary Range:

$71,800.00 - $112,860.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.