Director, Translational Pharmacology

Scorpion Therapeutics; United States; On-site; USD 189,000 - 246,000; Full time

Benefits offered by this job

Premium health benefits

Well-being programs

Life Insurance

Retirement with match

Generous paid time off

Job summary

Travere Therapeutics is seeking a Director of Translational Pharmacology to drive external evaluation of business development opportunities in rare diseases. You will integrate nonclinical, clinical, and translational data to support strategic decisions and develop translational pharmacology plans including MoA and biomarker strategies.

You'll lead cross-functional efforts, mentor researchers, and represent the company at external forums while coordinating with BD diligence teams to articulate

Qualifications

• Bachelor’s in life sciences; PhD/MD/PharmD preferred.
• 10+ years biopharma experience (or 6+ years with advanced degree).
• Strong nonclinical/clinical pharmacology knowledge.
• Experience evaluating drug candidates, MoA, disease biology, translational data to support decisions.
• Leadership of scientific initiatives/workstreams/teams.

Responsibilities

• Act as preclinical biology lead for BD opportunities across stages.
• Assess rationale, MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and feasibility.
• Review nonclinical/translational data with clinical/regulatory input; identify strengths/risks/gaps/value drivers.
• Partner with BD diligence teams on scientific assessment reports, diligence questions, risk summaries, and recommendations.
• Identify critical experiments to reduce uncertainty.
• Provide translational pharmacology expertise (in vitro/in vivo/ex vivo/PD/clinical pharmacology; biomarkers).
• Evaluate support for MoA, target engagement, dose rationale, patient selection, and clinical strategy.
• Lead/contribute to external scientific engagement; represent Travere at external forums.
• Support nonclinical/regulatory needs (package adequacy, development plans/budgets, investigator/briefing/regulatory sections).
• Provide scientific leadership, mentor colleagues, manage concurrent diligence/program activities.

Skills

Biopharma leadership

MoA evaluation

Translational pharmacology

Regulatory knowledge

Data synthesis

Team leadership

Education

Bachelor’s in Life Science

PhD/MD/PharmD preferred

Job description

Position Summary

Director, Translational Pharmacology—serve as a key scientific contributor to external evaluation of business development opportunities (rare disease), assessing therapeutic rationale, disease biology, mechanism of action, translational strategy, pharmacology data, biomarker approaches, and development feasibility. Integrate nonclinical, clinical, competitive, and translational data to support decision-making and contribute to internal/external translational pharmacology activities.

Responsibilities

• Act as preclinical biology lead/key contributor for BD opportunities (small molecules to biologics) across stages.
• Assess rationale, MoA, disease biology, pharmacology/toxicology, translational relevance, safety window, biomarker strategy, and feasibility.
• Review nonclinical/translational data with clinical/regulatory/competitive input; identify strengths/risks/gaps/value drivers.
• Partner with BD diligence teams on scientific assessment reports, diligence questions, risk summaries, and recommendations.
• Identify critical experiments/analyses/expert input to reduce uncertainty.
• Provide translational pharmacology expertise (in vitro/in vivo/ex vivo/PD/clinical pharmacology; biomarkers).
• Evaluate support for MoA, target engagement, dose rationale, patient selection, and clinical strategy.
• Lead/contribute to external scientific engagement (companies, academia, CROs, KOLs); represent Travere at external forums.
• Support nonclinical/regulatory needs (package adequacy, development plans/budgets, investigator/briefing/regulatory sections, identify gaps).
• Provide scientific leadership, mentor colleagues, manage concurrent diligence/program activities.

Qualifications (Required)

• Bachelor’s in Life Science/related field; PhD/MD/PharmD preferred.
• Minimum 10 years biopharma experience (or 6 years with advanced degree).
• Strong nonclinical/clinical pharmacology knowledge.
• Experience evaluating drug candidates, MoA, disease biology, and translational data to support decisions.
• Working knowledge of regulatory expectations for nonclinical/translational support.
• Leadership of scientific initiatives/workstreams/teams.
• Ability to synthesize complex data, communicate recommendations, and manage priorities.

Preferred

• Rare disease/rare metabolic/nephrology/immunology/inflammation experience.
• Due diligence experience (licensing/acquisition/collaboration).
• IND nonclinical toxicology/safety experience.
• Translational plan experience (MoA target engagement/PD biomarkers outcomes).
• Biomarker strategy/patient selection/human translational systems expertise.
• CRO/academic/external expert collaboration.
• Executive-level diligence/report/governance presentation experience.

Benefits

• Premium health, financial, work-life/well-being offerings; wellness/support programs; life insurance; disability; retirement with match; generous paid time off.

Compensation

Target base pay range: $189,000–$246,000.