Director, Translational Biology

Scorpion Therapeutics; San Francisco (CA); On-site; USD 220,000 - 300,000; Full time

Job summary

Vir Bio is seeking a Director of Translational Biology to steer biomarker strategy across the pipeline from preclinical to clinical development.

You will lead biomarker programs, design and execute strategies, validate assays, and collaborate with discovery, clinical, and data science teams to inform dose selection and study design.

This leader will manage external vendors, oversee regulatory documentation, and mentor a team of scientists in immunology and biomarkers.

Qualifications

• PhD or equivalent with extensive experience in immunology/biomarkers.
• Track record designing/ executing biomarker strategies across preclinical to clinical stages.
• Experience with immunology assays and translational biomarker development for clinical use.

Responsibilities

• Lead biomarker strategy for programs from preclinical to Ph1–3.
• Develop and execute biomarker plans to inform dose selection and development.
• Validate and oversee human immunologic/molecular assay methods in studies.

Skills

Biomarker strategy

Immunology

Flow cytometry

Team leadership

Education

PhD in Immunology

Tools

CRO coordination

Job description

THE OPPORTUNITY

Vir Bio is looking for a Director, Translational Biology to drive biomarker strategy across the pipeline, from preclinical discovery through clinical development.

What You’ll Do

• Serve as biomarker lead for specific programs from preclinical through clinical development
• Develop and execute biomarker strategies, including preclinical biomarker assessments and clinical biomarker plans to inform dose selection and development
• Plan and oversee validation and execution of human immunologic and molecular methods in preclinical and clinical studies
• Support regulatory submission deliverables/documentation (e.g., INDs, BLAs/NDAs) and contribute to INDs, IBs, clinical study protocols, and related documents
• Manage pilots and method validation with external vendors to ensure robust biomarker assays
• Collaborate with discovery, clinical, and data science to refine hypotheses, design studies, and analyze datasets
• Lead a team, providing scientific guidance and mentorship in immunology and biomarkers
• Represent the Research function in selected external meetings
• Develop and manage internal/external resources (e.g., CROs, academic collaborators) to advance biomarker discovery and implementation

Who You Are And What You Bring

• PhD + 10+ years, or MS + 13+ years in immune-oncology/immunology; drug and biomarker development from preclinical through Ph1–3
• Proven track record designing/executing biomarker strategies (identification, validation, characterization in vitro/in vivo)
• Deep expertise in immunology and immune-oncology
• Proficiency with immunology assays (e.g., polychromatic flow cytometry, cytotoxicity, T cell function, antigen presentation)
• Experience developing/implementing validated biomarker methods for clinical use; oversight of assay pilots and method validation with vendors/CROs
• Background contributing to regulatory documents
• Familiarity with diagnostic/companion diagnostic development for patient enrichment/selection/prediction
• Demonstrated scientific and people leadership (managing scientists; leading cross-functional teams)

Applicants must be authorized to work in the U.S.; Vir is unable to sponsor or take over visa sponsorship.