Director, Technical (CMC) Project Management

Structure Therapeutics Inc.; South San Francisco (CA); On-site; USD 209,000 - 260,000; Full time

Benefits offered by this job

401k match

Unlimited PTO

Medical, dental, and vision insurance

Paid holidays

Job summary

Structure Therapeutics Inc. is seeking a Director Technical (CMC) Project Management in South San Francisco. This leadership role requires extensive project management expertise supporting late-stage development and commercialization in the biotech space. Responsibilities include integrated project planning, execution, budgeting, and cross-functional collaboration. Ideal candidates will have 12+ years of relevant experience and a solid educational background in Chemistry or Engineering, alongside proficiency in project management tools. This role offers competitive compensation plus a range of benefits including equity, insurance, and unlimited PTO.

Qualifications

• 12+ years of progressive experience in pharmaceutical or biotech CMC functions.
• 5+ years of experience in project management for late-stage development.
• Direct experience with small molecule and oral solid dosage products.
• Strong understanding of CMC development and manufacturing processes.
• Excellent communication and cross-functional influence.

Responsibilities

• Lead end-to-end CMC project management for late-stage development programs.
• Develop and manage detailed project plans including timelines and dependencies.
• Facilitate team meetings and manage budgets and financial tracking.
• Establish best practices for project management and communications.

Skills

Project management

Risk management

Cross-functional collaboration

Budgeting

Leadership

Education

B.S. in Chemistry, Engineering, or related discipline

Advanced degree (M.S. or Ph.D.)

Tools

MS Project

Smartsheet

Excel

PowerPoint

Job description

Position Summary

Reporting to SVP Technical Operations, the Director Technical (CMC) Project Management will provide technical CMC project management support and leadership across all late‑stage development programs through commercialization and lifecycle management. This role is responsible for driving integrated project planning, execution, budget planning, risk management, cross‑functional alignment and meeting facilitation support for the Tech Ops leadership and CMC Teams.

The successful candidate is a seasoned, technically savvy, project management expert that will serve as a member of the Technical Operations leadership team and be responsible for establishing best‑in‑class project management practices, tools and discipline within Tech Ops as well as representing the department in various companywide cross‑functional team forums.

Job Responsibilities

Strategic CMC Project Leadership

• Lead end‑to‑end CMC project management for late‑stage development programs through commercial launch and lifecycle management.
• Develop and maintain integrated cross‑functional project plans covering drug substance, drug product, analytical, quality, regulatory, and supply chain activities.
• Ensure alignment of project execution with overall program strategy, timelines, and business objectives.
• Serve as a key member of the Technical Operations leadership team.

Project Planning, Tracking and Execution

• Develop and manage detailed project plans (Gantt‑based) including timelines, milestones, dependencies, and critical paths.
• Track execution of activities across internal teams and CDMO partners across multiple time zones.
• Monitor progress against timelines, budgets, and deliverables; proactively identify and resolve risks and issues.
• Drive accountability for action items, deliverables, and project milestones.

Team Facilitation and Meeting Management

• Facilitate weekly CMC team meetings and other governance forums.
• Develop proactive agendas and prepare supporting materials to drive effective decision‑making.
• Establish and enforce best practices for meeting management, communication, and cross‑functional information flow.
• Ensure clear documentation of decisions, actions, and follow‑ups.

Budgeting, Financial Tracking & Reporting

• Partner with Tech Ops department heads to develop project and multi‑year departmental budgets.
• Collaborate with Finance and CDMOs to track spending, accruals, and budget performance.
• Ensure alignment between project plans, work orders, and financial forecasts.
• Provide regular financial and project status reporting to leadership.

Cross‑Functional & External Coordination

• Interface with Tech Ops functional leads, including External Manufacturing, Process Development, Analytical, Quality, Regulatory CMC, and Supply Chain.
• Support department heads and working teams coordinate project activities across a network of global CDMOs.
• Partner with Procurement and Legal to ensure timely execution of work orders, contracts, and budget approvals.
• Interface with company‑wide program teams and project managers to ensure consistent reporting of dashboards, progress, and risks.

Risk Management & Continuous Improvement

• Develop and maintain project risk registers and mitigation strategies.
• Proactively manage project risks related to timelines, cost, quality, and supply.
• Identify and drive continuous improvement opportunities including timeline acceleration, cost optimization, and risk reduction.
• Ensure lessons learned are captured and implemented across programs.

Project Management Excellence

• Establish best‑in‑class project management standards, tools, and processes within Technical Operations.
• Drive a culture of collaboration, accountability, innovation, and execution excellence.
• Serve as both a strategic leader and hands‑on contributor in a growing organization.
• Mentor and develop project management capabilities across the organization.

Qualifications

• B.S. in Chemistry, Engineering, or related discipline required; advanced degree (M.S. or Ph.D.) and accreditation in Project Management preferred.
• 12+ years of progressive experience in pharmaceutical or biotech CMC functions, including one or more of the following: manufacturing, process development, analytical, quality, supply chain, or regulatory CMC.
• At least 5+ years of experience in project management supporting late‑stage development through commercial launch.
• Direct experience with small molecule and oral solid dosage (OSD) products.
• Demonstrated experience supporting commercialization and lifecycle management activities.
• Strong understanding of CMC development, manufacturing, regulatory and supply processes and requirements.
• Expertise in project management tools (e.g., MS Project, Smartsheet, Excel, PowerPoint).
• Strong experience developing and managing detailed project plans and timelines.
• Good understanding of financial planning, budgeting, and accrual tracking processes.
• Proven ability to operate effectively in a fast‑paced, matrixed, and global environment.
• Strong analytical, problem‑solving, and decision‑making capabilities.
• Ability to think strategically while maintaining attention to detail and execution.
• Excellent communication and cross‑functional influence.

Travel Required

up to 25%, globally

Equal-Opportunity Employer

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Compensation & Benefits

Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $209,000–$260,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience.

At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance‑based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.