Director, Project Management Oncology

BioSpace; Philadelphia (Philadelphia County); On-site; USD 192,000 - 288,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) retirement plan

Flexible paid vacation

Job summary

Jazz Pharmaceuticals is seeking a Director of Project Management to lead cross-functional oncology development programs, acting as the COO of the asset. You will partner with Global Project Lead, harmonize timelines across indication sub-teams, and drive risk mitigation and governance across Planisware and Smartsheet.

In this senior role, you will shape execution strategies, prepare executive governance materials, and foster high-performing teams while navigating complex regulatory filings and

Qualifications

• Experience in biopharmaceutical/biotechnology industry with cross-functional R&D project leadership.
• Proven ability to guide projects through full drug development lifecycle, including regulatory filings and launch.
• Experience leading oncology development programs (targeted therapies, immuno-oncology, or biologics).
• Ability to manage a single program across multiple indications with matrix teams.

Responsibilities

• Lead asset strategy and execution as COO of the asset.
• Prepare executive governance materials for leadership review.
• Direct and align multiple Project Managers across indication sub-teams.
• Harmonize timelines and dependencies; optimize critical path delivery.
• Maintain data integrity across Planisware and Smartsheet for milestones and resources.
• Lead risk management and mitigation across the program; drive decision-ready scenarios.

Skills

Executive communication

Cross-functional leadership

Strategic thinking

Risk management

Education

Bachelor’s degree in Life Sciences, Engineering, or Business

Advanced degree (PhD, PharmD, MS, or MBA)

Tools

Planisware

Smartsheet

Oracle

Job description

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information. Brief Description: The Director, Project Management is a senior operational leader within Pipeline and Project Management (PPM) accountable for cross-functional leadership, operational strategy, and integrated execution across high-visibility oncology development programs. Operating as the "COO of the Asset," the PM serves as the strategic operational partner to the Global Project Lead (GPL). This role oversees complex oncology program often spanning multiple indications, coordinating a network of Project Managers across indication teams to harmonize timelines, resolve cross-indication dependencies, and drive alignment to the overarching asset strategy. By establishing a single source of truth across enterprise platforms (Planisware and Smartsheet), driving proactive risk mitigation, and framing decision-ready scenarios for leadership, the PM optimizes the critical path to accelerate innovative therapies to patients. Essential Functions Asset Leadership & Strategy Execution: Partner directly with the Global Project Led to translate the target product profile and clinical development strategy into an executable integrated program plan spanning all target indications. Prepare executive presentations for the asset for governance and executive leaders. Formulate multi-scenario operational models (base-case, accelerated, de-risked) with clear trade-off analyses (speed vs. cost vs. risk vs. value) to provide decision-ready proposals for executive and portfolio governance. Foster High-Performing Teams: Cultivate a purpose-driven, high-performing team culture rooted in psychological safety, transparency, mutual accountability, and urgent collaborative problem-solving across all matrix lines. Multi-PM & Sub-Team Orchestration: Direct and align multiple Project Managers leading specific indication sub-teams and functional workstreams, ensuring harmonized operational standards, milestone alignment, and cohesive delivery across the program. Cross-Functional Matrix Leadership: Lead and influence cross-functional Core Teams (Clinical Development, Regulatory Affairs, CMC/Technical Operations, Nonclinical, Medical Affairs, and Commercial) without formal authority to deliver against program commitments. Timeline Optimization & Critical Path Delivery: Interrogate project assumptions, resolve operational bottlenecks, and compress cycle times across the late-stage development lifecycle through global regulatory filings (NDA/BLA/MAA) and commercial launch. Cross-Indication Interdependency Management: Map, track, and proactively manage critical dependencies across indications (e.g., clinical trial supplies, safety readouts, shared regulatory dossiers) to safeguard overarching program momentum. Single Source of Truth Governance: Maintain baseline data integrity and transparency across enterprise platforms (Planisware and Smartsheet) for indication milestones, deliverables, and resource allocations. Risk Register & Mitigation Ownership: Actively lead comprehensive asset risk management, maintain dynamic risk registers, quantifying impact and probability, and driving actionable mitigation pathways. Resource & Budget Management: Partner closely with Finance and Resource Management to forecast and monitor project demand, external spend, and capacity requirements across all indications. Executive Communication: Act as the operational spokesperson for the asset, communicating milestone progress, key operational trade-offs, and critical risks to executive leadership and governance committees. Required Knowledge, Skills, and Abilities Experience: Excellent experience biopharmaceutical/biotechnology industry, with at solid dedicated cross-functional R&D project management leadership. Drug Development Lifecycle: Proven expertise guiding projects through the full drug development lifecycle, from early development through clinical phases, regulatory approvals, and commercial launch. Late-Stage & Filings Experience: Demonstrated track record delivering late-stage registrational programs (Phase 2b/Phase 3); direct experience preparing or executing major Health Authority filings (NDA, BLA, MAA, or supplemental sNDA/sBLA) strongly preferred. Therapeutic Expertise: Prior experience leading Oncology development programs (e.g., targeted therapies, immuno-oncology, or biologics) preferred. Multi-Indication & Scale: Proven ability to manage a single program/asset across multiple therapeutic indications while coordinating multiple Project Managers within an integrated asset structure. Matrix Influence: Demonstrated mastery in leading without formal line authority, fostering accountability, and driving consensus across senior cross-functional leaders. Executive Presence: Strong communication and storytelling skills, with the ability to synthesize complex timeline, risk, and resource data into crisp executive summaries. Certifications: PMP, PgMP, or equivalent project management certifications preferred. Enterprise PM Systems: Advanced, hands-on proficiency in Planisware, Smartsheet and Oracle for enterprise scheduling, risk tracking, budget and resource demand management. Required/Preferred Education and Licenses Education: Bachelor’s degree in Life Sciences, Engineering, Business, or related field required; Advanced degree (PhD, PharmD, MS, or MBA) strongly preferred. Certifications: PMP, PgMP, or equivalent project management credentials preferred. Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. FOR US BASED CANDIDATES ONLY Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $192,000.00 - $288,000.00 Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis. At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company’s Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz’s Long Term Equity Incentive Plan. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation.