Director - Oncology Research

Amgen Inc. (IR); South San Francisco (CA); On-site; USD 208,000 - 282,000; Full time

Job summary

Amgen Inc. in the United States seeks a Director of Oncology Research to lead a portfolio of antibody-based therapeutics for solid tumors.

You will supervise cross-functional teams and external collaborations to translate strategy into actionable programs, with a focus on T-cell engagers and bispecific antibodies. The role emphasizes translational biology, cancer cell biology, and the leadership of a creative, high-performing research group in a fast-paced, matrixed environment with high

Qualifications

• PhD or equivalent with leadership of teams in oncology R&D.
• Experience managing people and programs across discovery to development.
• Strong knowledge of cancer biology, translational pharmacology, and tumor biology.

Responsibilities

• Lead preclinical research for T cell engager programs and bispecific antibodies.
• Direct a portfolio of oncology research programs and external collaborations.
• Manage a high-performing team and cross-functional partners in a matrixed environment.
• Collaborate with tumor biology, translational research, and portfolio strategy groups.
• Incorporate AI/ML approaches to accelerate target and biology evaluation.

Skills

Leadership

Strategic thinking

Cross-functional

AI/ML familiarity

Education

Doctorate in Cancer Biology/Cell Biology/Genetics or related field

Master’s in Cancer Biology/Cell Biology/Genetics or related field

Bachelor’s in Cancer Biology/Cell Biology/Genetics or related field

4+ years people/leadership experience

Job description

Career Category Research Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Director – Oncology Research

What you will do

Let’s do this. Let’s change the world. Amgen is a leader in the discovery and development of innovative cancer therapeutics. The Oncology Research team seeks a Director of Research to develop and lead a portfolio of antibody-based therapeutics for solid tumors. In this role, you will work cross-functionally to implement and advance next-generation approaches for cancer therapeutics. The ideal candidate will have direct experience leading oncology T-cell engager programs from discovery to development candidate nomination, with experience using translational biology approaches to inform clinical development. A deep and broad understanding of cancer cell biology, including human genetics, cell growth signaling pathways, mechanisms of response and resistance, and translational pharmacology will be essential. You will be responsible to lead project teams and external collaborations, as well as to inspire and develop a creative, dedicated research team. You will be an exceptional scientific leader who can translate strategy to execution in a fast-paced, changing matrixed environment. This role has the potential for high visibility within Amgen and externally.

Key Responsibilities

• Lead preclinical research for T cell engager focused on identification of novel target opportunities, prioritization of discovery investments, and implementation of next-generation target discovery approaches.
• Build and lead a portfolio of innovative research programs focused on bispecific antibodies.
• Lead a team of project leaders and lab-based scientists to; create an inclusive high-performing environment that enables new target discovery, rigorous science and efficient execution.
• Lead cross-functional teams and engage key internal partners to integrate tumor biology, target validation, translational research, therapeutic modality considerations, and portfolio strategy.
• Establish productive external scientific collaborations and contribute to evaluation of external opportunities, including business development diligence.
• Partner effectively with peers across research and development to advance new science and integrate technology with tumor cell biology, including application of AI/ML approaches to target and biology evaluation.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 4 years of directly related experience
• Master’s degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 8 years of directly related experience
• Bachelor’s degree in Cancer Biology, Cell Biology, Genetics, or related field [and relevant post-doc where applicable] and 10 years of directly related experience
• In addition to meeting at least one of the above requirements, you must have at least 4 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced above.

Preferred Qualifications

• Doctoral degree in a Cancer Biology, Cell Biology or related field with at least 12 years industry experience following completion of postdoctoral training.
• Demonstrated experience leading drug discovery and development programs through IND/CTA-enabling activities, with strong experience in large-molecule therapeutics and understanding of the preclinical data sets required for development candidate nomination.
• Deep understanding of oncology and tumor biology; expertise in NSCLC or lung cancer biology is strongly preferred.
• Knowledge of antibody engineering approaches, with direct experience designing and evaluating modalities including T-cell engagers and antibody-drug conjugates.
• Established record of building, mentoring, and leading high-performing research teams.
• Exceptional written and verbal communication skills, with the ability to synthesize complex data into clear strategic recommendations.
• Demonstrated scientific impact through publications, patents, invited presentations, or other external recognition.
• Demonstrated ability to use AI/ML to accelerate research and translational biology.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Equal Opportunity

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

208,353.70USD -281,890.30 USD

Amgen Commitment

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

For more information, visit www.amgen.com and follow us on www.twitter.com/amgen