Director of Global Ophthalmology Clinical Operations

RhyGaze AG; Philadelphia (Philadelphia County); On-site; USD 200,000 - 280,000; Full time

Benefits offered by this job

Breakthrough therapies

Experienced team

Meaningful impact

Collaborative culture

US work eligibility

Job summary

RhyGaze, a biotech company advancing gene therapies for blinding retinal diseases, is seeking an Associate Director/Director of Clinical Operations. You will lead day-to-day management of ophthalmology trials, oversee CROs and vendors, and ensure trials run on time and within budget.

You will develop study timelines, enrollment projections, study budgets, and contribute to protocol, ICF, reports, and regulatory documents while maintaining a compliant TMF and collaborating with global teams.

Qualifications

• 8–10 years in clinical operations with global PhI–PhIII experience.
• Proven ability to manage sites and CROs.
• Comfort with ambiguity in a fast-paced environment.
• Strong written and verbal communication.
• Analytical and detail-oriented with problem-solving skills.
• Experience in ophthalmology or gene therapy preferred.

Responsibilities

• Lead day-to-day management of ophthalmology trials and ensure deliverables and budget.
• Develop study timelines, enrollment projections, and budgets.
• Oversee CROs and external vendors.
• Contribute to study documents (protocols, ICFs, CRFs, final reports).
• Ensure TMF setup and ongoing maintenance.
• Ensure trials comply with protocol, GCP, SOPs, and regulations.
• Provide operational input into development plans and portfolio strategy.
• Develop clinical operations processes and SOPs.
• Collaborate with cross-functional teams globally to deliver programs on time and budget.
• Identify risks and propose actionable mitigations.
• Develop and mentor clinical operations staff as teams grow.

Skills

Clinical operations

Vendor management

Budget management

Cross-functional leadership

GCP compliance

Stakeholder management

Risk management

Team leadership

Education

Bachelor's degree in life sciences

Tools

EDC systems

CTMS

Regulatory submissions software

Job description

RhyGaze, a biotech company advancing gene therapies for blinding retinal diseases, is seeking an Associate Director/Director of Clinical Operations. You will lead day-to-day management of ophthalmology trials, oversee CROs and vendors, and ensure trials run on time and within budget.

You will develop study timelines, enrollment projections, study budgets, and contribute to protocol, ICF, reports, and regulatory documents while maintaining a compliant TMF and collaborating with global teams.