Director of Biostatistics—Clinical Development Lead

Calico Life Sciences; South San Francisco (CA); Sur place; USD 235 000 - 300 000; Plein temps

Avantages offerts par ce poste

Annual bonuses

Résumé du poste

Calico Life Sciences seeks an Associate Director/Director of Biostatistics to provide statistical analysis leadership for clinical programs. The role collaborates with scientists across disciplines, guiding study design, analysis plans, and regulatory submissions to derive meaningful inferences about human aging.

The position is onsite in South San Francisco. The successful candidate will lead biostatistical teams, develop innovative designs (adaptive, Bayesian, simulations), and manage external

Qualifications

• PhD or MS with extensive experience in biostatistics and clinical programs.
• Ability to lead biostatistical support across development phases.
• Experience with regulatory submissions and external collaborations.

Responsabilités

• Independently lead biostatistical support for assigned therapeutic programs and clinical studies across development phases
• Develop statistical strategies aligned with clinical development objectives and regulatory requirements
• Collaborate with clinical and scientific teams to evaluate study design alternatives, assess risks and uncertainties, and support data-driven development decisions
• Provide statistical input into clinical development plans, study protocols, endpoint selection, sample size considerations, and overall evidence-generation strategies
• Develop and evaluate innovative trial designs, including adaptive designs, Bayesian approaches, and simulation-based methods, as appropriate
• Provide statistical expertise for studies involving small sample sizes, heterogeneous patient populations, rare diseases, and limited clinical data
• Communicate statistical concepts, assumptions, limitations, and implications clearly to cross-functional teams

Connaissances

Biostatistics leadership

Bayesian methods

Study design

Regulatory submissions

Statistical programming

Formation

PhD in Biostatistics/Statistics

MS in Biostatistics/Statistics

Description du poste

Calico Life Sciences seeks an Associate Director/Director of Biostatistics to provide statistical analysis leadership for clinical programs. The role collaborates with scientists across disciplines, guiding study design, analysis plans, and regulatory submissions to derive meaningful inferences about human aging.

The position is onsite in South San Francisco. The successful candidate will lead biostatistical teams, develop innovative designs (adaptive, Bayesian, simulations), and manage external