Director, Medicinal Chemistry

Exelixis Inc; Alameda (CA); In loco; USD 234.000 - 296.000; Tempo pieno

Vantaggi offerti da questo lavoro

401k plan

Medical coverage

Dental coverage

Vision coverage

Life and disability insurance

Flexible spending accounts

Discretionary annual bonus program

Company stock purchase program

Long-term incentives

15 accrued vacation days

17 paid holidays

Sick days

Descrizione del lavoro

Exelixis Inc. is seeking a Director of Medicinal Chemistry to lead a senior team dedicated to designing and synthesizing novel compounds for portfolio projects.

You will oversee a group of chemists, drive project progression from target validation to lead optimization, and collaborate with biology, DMPK, and safety teams to advance high-quality drug candidates. The role demands excellence in strategy, communication, and scientific leadership.

Competenze

• Ph.D. and 8+ years related experience or equivalent.
• Experience supervising staff and matrix teams.
• Deliver projects from target identification through optimization to drug candidates.
• Strong bench skills and knowledge of modern synthetic chemistry techniques.
• Knowledge of IP matters related to drug discovery.

Mansioni

• Provide scientific and transformative leadership to chemistry team.
• Collaborate with biology, DMPK and safety teams to advance quality compounds.
• Drive medicinal chemistry projects from target validation to lead optimization and drug candidate selection.
• Present at project team and departmental meetings.
• Maintain laboratory notebooks per company policies and EH&S guidelines.
• Contribute to writing patents, manuscripts and conference presentations.

Conoscenze

Leadership

Medicinal chemistry

Drug discovery

SAR analysis

Project management

IP / patents

Formazione

Ph.D. in Chemistry

Strumenti

MS Word

MS PowerPoint

MS Excel

Descrizione del lavoro

SUMMARY/JOB PURPOSE

The Director, Medicinal Chemistry is a highly skilled and motivated senior level medicinal chemist who manages our small molecule drug discovery team. The ideal person is an exceptional chemistry team leader, overseeing a team of chemists to design and synthesize novel compounds for portfolio projects.

ESSENTIAL DUTIES AND RESPONSIBILITIES

• Provide scientific and transformative leadership to chemistry team members
• Collaborate with biology, DMPK and safety teams to advance quality compounds as potential drug candidates.
• Drive medicinal chemistry projects from target validation to chemical equity identification to lead optimization and drug candidate selection
• Participate and present in project team and departmental research meetings
• Maintain laboratory notebooks in accordance with company policies and practices
• Comply with safe laboratory practices and EH&S guidelines and promote a culture of safety in the laboratory
• Contribute to the writing of technical documents, patent applications, scientific manuscripts and preparation of conference presentations

SUPERVISORY RESPONSIBILITIES

• Supervises staff, including hiring, scheduling, and assigning work, reviewing performance, and recommends salary increases, promotions, transfers, demotions, or terminations.
• Directly supervises employee(s) through a dotted line structure or via other subordinate supervisors.

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS

• Doctoral degree (Ph.D.) and a minimum of 8 years related experience; or, Equivalent combination of education and experience.
• Experience managing as a direct supervisor and in matrix teams
• Experience managing projects and/or workgroups in biotechnology organizations including experience with budget procedures
• Proven track record of delivering projects from target identification through optimization to high-quality drug candidates as evidenced by publications and/or patent applications
• Knowledgeable in all aspects of drug discovery including structure-based drug design and understanding of related disciplines
• Strong organic and medicinal chemistry bench skills with detailed knowledge of modern synthetic chemistry techniques, purification methods, and analytical techniques
• Target compound and synthetic pathway design
• Excellent problem solving and SAR analysis skills
• Extensive experience in a medicinal chemistry laboratory conducting research experiments and operating general chemistry equipment.
• General experience working with computers including MS Word, MS PowerPoint and MS Excel required.
• Extensive knowledge of organic and medicinal chemistry techniques, theories and practices.
• Comprehensive understanding of current approaches in medicinal chemistry and the ability to incorporate them into the drug discovery program.
• Extensive knowledge of intellectual property matters related to drug discovery.
• Sets goals with understanding of priority and impact to program, department and organization.
• Applies advanced scientific and technical principles, theories and concepts.
• Contributes to the development of new principles and concepts.
• Efficient use of scientific literature and chemical/scientific databases
• Ability to initiate program efforts and work effectively with CRO partners
• Good interpersonal skills, flexibility and works well within a team environment
• Excellent written and verbal communication skills

JOB COMPLEXITY

Works in a fast-paced team environment as we continue to grow and evolve requiring regular reprioritization of projects while adhering to timelines and achievement of deliverables. As a subject matter expert, has an in-depth knowledge of medicinal chemistry and has a detailed understanding of cross functional disciplines. Exercises independent judgment in methods, techniques and evaluation of criteria for obtaining results.

LOCATION & COMPENSATION

Location: Alameda, CA Range for this position: $234,000 - $295,500 The base pay offered will take into account job-related knowledge, skills, experience and internal equity, among other factors.

BENEFITS

• 401k plan with generous company contributions
• Group medical coverage
• Dental coverage
• Vision coverage
• Life and disability insurance
• Flexible spending accounts
• Discretionary annual bonus program, or if field sales staff, a sales-based incentive plan
• Company stock purchase program
• Long-term incentives
• 15 accrued vacation days in their first year
• 17 paid holidays including a company-wide winter shutdown in December
• Up to 10 sick days throughout the calendar year

ACCOMMODATIONS

If you have a disability and need an accommodation in relation to the recruiting process, please email us at: [e-mail].

WORKING CONDITIONS

Our office is a modern space that fosters collaboration and creativity. Teams work closely together, sharing ideas and solutions in a supportive atmosphere. We provide all necessary equipment, including dual monitors and ergonomic chairs, to ensure a comfortable workspace.

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

EQUAL OPPORTUNITY EMPLOYER STATEMENT

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.

OUR MISSION

Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts, and grow our team in areas such as Drug Discovery, Clinical Development and Commercial. As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we’re seeking to add talented, dedicated employees to power our mission. Cancer is our cause. Make it yours, too.