Director, Integrative Sciences

GlaxoSmithKline plc; Collegeville (PA); Híbrido; USD 190.000 - 316.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Annual bonus

Healthcare

Pension plan

Share plan

Savings programme

Hybrid work model

Descripción de la vacante

GSK seeks a visionary Director, Integrative Sciences to lead diagnostic innovation in oncology, leveraging AI/ML, multi-modal omics, and translational biomarker strategies. You will shape biomarker, diagnostic, and clinical development programs, especially for ADCs, and guide analyses of trial biomarker data to enable translational medicine.

Based at Cambridge, MA with plans to relocate offices to Cambridge, UK, the role offers a hybrid work model and a competitive package including annual

Formación

• PhD in computational biology, bioinformatics, or related field.
• 7+ years in pharma/biotech with oncology biomarker focus.
• Proven cross-functional leadership in matrix environments.
• Experience with diagnostic platforms and translational medicine.
• Strong statistical and data analysis skills.

Responsabilidades

• Lead innovation in diagnostic tech, including AI/ML approaches.
• Develop oncology foundational models for complex datasets.
• Apply biomarkers to optimize patient selection and dosing strategies.
• Oversee integration of models to inform translational medicine.
• Collaborate with CPMS, Diagnostics, and AI/ML teams for insights.
• Evaluate new tech platforms to advance diagnostic innovation.

Conocimientos

PhD in computational biology

Oncology biomarker analysis

Cross-functional leadership

AI/ML in diagnostics

GitHub / HPC

Cloud computing

Educación

PhD or equivalent in computational biology/related field

Herramientas

GitHub

R Shiny

R Markdown

Python

HPC

Descripción del empleo

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

Director, Integrative Sciences

We are seeking a visionary leader to join our Oncology Translational Medicine Integrative Sciences team as the Director of Integrative Sciences. This role will focus on driving innovation in diagnostic technology platforms, leveraging cutting-edge approaches such as oncology foundational models, real world data, multi-modal omics data, AI/ML, computational pathology, and biomarker discovery to transform how we understand and treat cancer. The successful candidate will play a pivotal role in shaping biomarker, diagnostic, and clinical development strategies, particularly in the context of antibody-drug conjugates (ADCs), T cell engagers and other advanced therapeutic modalities, while maintaining responsibilities for analyzing clinical trial biomarker data to enable translational medicine approaches.

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK Ware in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Key Responsibilities

• Lead innovation in emerging diagnostic technologies, including ctDNA, computational pathology, advanced imaging techniques, and multi-modal biomarker platforms, to enhance patient stratification, therapeutic targeting, and mechanism-of-action insights.
• Develop and apply oncology foundational models and AI/ML analytical approaches to complex clinical, real-world and biomarker datasets, including high-dimensional data such as single-cell transcriptomics, spatial omics, proteomics, and cfDNA.
• Serve as a subject matter expert in application of analytical methods and emerging diagnostic technologies to enable biomarker discovery and diagnostic strategies to optimize patient selection, dose determination, and combination therapy approaches with a focus on antibody-drug conjugates (ADCs).
• Oversee the integration of oncology foundational models to inform translational medicine and clinical development strategies ensuring robust interpretation, practical implementation and timely communication across matrix teams.
• Collaborate with cross-functional teams, clinical development, CPMS (Clinical Pharmacology and Modelling Simulation), Diagnostic, Translational Research, and AI/ML teams, to evaluate and apply complementary data analytics approaches for meaningful insights into complex biology.
• Lead efforts to identify, evaluate, and implement emerging technology platforms to advance diagnostic innovation and support pipeline growth.
• Provide leadership and accountability for clear and timely communication of data analysis outputs, complex analytical principles, and models to diverse stakeholders, including senior leaders and non-technical partners.
• Champion the integration of biomarker and diagnostic strategies into clinical development plans, ensuring alignment with oncology research unit and translational medicine objectives.
• Drive the application of computational pathology and AI-driven image analysis to enhance diagnostic capabilities and biomarker discovery in oncology programs.
• Support the evaluation of academic partnerships and external technology platforms, ensuring alignment with Oncology Translational Medicine goals and innovation priorities.
• Contribute to due diligence efforts for business development opportunities, leveraging expertise in advanced analytics and emerging diagnostic technologies.

Basic Qualifications & Skills

• PhD degree or equivalent experience/training in computational biology, bioinformatics, machine learning, computational pathology, or a related field.
• 7+ years of applied experience in Pharma/Biotech or an academic setting, with a focus on oncology research, diagnostic innovation, and biomarker analysis.
• Demonstrated ability to lead and influence cross-functional teams in a matrix environment, driving alignment and delivering impactful outcomes.
• Experience with emerging diagnostic platforms and technologies, including their application to translational medicine and clinical development.
• Demonstrated advanced knowledge of statistical and analytical methods relevant to the analysis of complex high-dimensional heterogeneous datasets.
• Experience with GitHub, development of R Shiny applications/R markdown, and working in cloud or high-performance computing (HPC) environments.

Preferred Qualifications & Skills

• MD degree with oncology clinical development experience is highly desirable and considered an upside for this role.
• Expertise in oncology foundational models and AI/ML analytical approaches applied to complex biomarker datasets.
• Proficiency in coding skills (e.g., R, Python) and strong working knowledge of bioinformatics databases, resources, and tools.
• Proven ability to analyze and interpret high-dimensional datasets (e.g., single-cell and spatial transcriptomics, proteomics, cfDNA) using advanced modeling techniques.
• Experience with computational pathology and AI-driven image analysis in the context of diagnostic innovation.
• Strong knowledge of clinical trial biomarker data analysis and its application to precision medicine strategies.
• Demonstrated experience with antibody-drug conjugates (ADCs) and their associated biomarker and diagnostic strategies.
• Proven leadership experience in driving diagnostic innovation and implementing emerging technologies in oncology research.
• Strong track record of integrating preclinical and clinical biomarker data to inform translational medicine strategies.
• Familiarity with regulatory requirements and data standards for transitioning programs into clinical trials.
• Strategic mindset with the ability to influence and drive decision-making in a matrix environment.

Our Approach to R&D

Analytical Thinking, Clinical Data Interpretation, Clinical Data Review, Clinical Development, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Regulatory Affairs, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations

Skills

• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is an Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.