Director, HTA, Value & Evidence, Lung Cancer

Pfizer; Denver (CO); Hybrid; USD 177,000 - 294,000; Full time

Job summary

Pfizer is seeking a Director of HTA, Value & Evidence (HV&E) for the US Lung Cancer portfolio. The role leads US evidence generation, collaborates with Global HV&E and US Medical, and drives strategies to optimize patient access and appropriate use of medicines.

The position requires an advanced degree and 7+ years in HEOR (5+ for PharmD/PhD), with extensive experience in real-world evidence, economic modeling, and market access. Hybrid work with travel, competitive compensation, and benefits.

Qualifications

• Broad health services research methods and tools knowledge.
• Experience with health economic modeling and PRO data.
• Ability to manage complex non-interventional studies.
• Understanding of US drug development and healthcare environment.
• Strong written and oral English communication skills.
• Execution mindset with multitasking and budgeting capabilities.
• Ability to influence across matrix teams and external partners.

Responsibilities

• Lead development of evidence generation strategy for lung cancer portfolio.
• Coordinate input from US Medical, Market Access, and partners to inform evidence needs.
• Design and execute HEOR studies from concept to publication.
• Develop US value & evidence materials like AMCP dossiers and literature reviews.
• Provide strategic input into trial designs and PRO data interpretation.
• Disseminate HEOR materials per regulatory guidance and SOPs.
• Develop partnerships with external experts and payers to support asset strategies.

Skills

HEOR knowledge

Health economics modeling

Real World Evidence

Cross-functional collaboration

Project management

Strategic influence

Education

Graduate degree (MSc/MPH/PhD)

PharmD/PhD in HEOR or related fields

Job description

ROLE SUMMARY

The Director, HTA, Value & Evidence (HV&E), US, Lung Cancer will support the strategic goals of the Oncology Division by driving optimal patient access & appropriate use of medicines within the lung cancer & precision medicine portfolio.

This role directly impacts the ability to achieve business objectives on a US basis by providing strategic guidance and robust evidence development relevant to achieve appropriate use by providers and optimal patient access by demonstrating the value of our medicines. The HV&E Director will be responsible for developing and executing against the US evidence generation strategy, including direct oversight of evidence generation activities and dissemination of technical deliverables, in collaboration with Global HV&E and US Medical.

This position will work closely with Global HVE, GASP, cross-functional US teams, and cross-company alliance partners to foster a culture that promotes innovation, collaboration and thrives on doing better for Pfizer’s patients and for US healthcare providers and systems.

ROLE RESPONSIBILITIES

• Lead the development of the evidence generation strategy to support the value of medicines in the lung cancer & precision medicine portfolio in the Oncology Division in close partnership with the cross-functional matrix team.

• Lead the coordination of input from US Medical, field-facing colleagues, US Market Access, cross-alliance partners and GASP and USMA team on evidence needs and ensure that the input is appropriately incorporated to develop and integrate the evidence strategy to support market access needs at launch and through lifecycle.

• Lead the design and execution of HEOR studies (eg, network meta-analyses, Real World Evidence studies such as non-interventional studies), including studies involving site engagement, chart abstraction, and retrospective data collection, from concept through publication.

• Lead the timely development of US value & evidence strategy in coordination with US Medical, Global HV&E, customer-facing deliverables such as AMCP dossiers, systematic literature reviews, economic models, and innovative tools to successfully support reimbursement and access requirements in conjunction with US customer facing teams.

• As needed, provide strategic input into clinical trial designs (eg, patient populations, comparators, endpoints) and analysis and interpretation of PRO data to enable successful differentiation negotiations, reimbursement, and appropriate patient access with US payers, and regulatory decision makers.

• Partner with internal & cross-alliance stakeholders to ensure appropriate customer facing dissemination of HEOR materials per regulatory guidance and internal SOPs, including development of PVPs, promotional materials and FDAMA 114 compliant materials.

• Develop strategic partnerships and research collaborations with key external experts, healthcare policy makers, payers, and various academic and community oncology settings to support asset strategies.

BASIC QUALIFICATIONS

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

• Graduate degree minimum (e.g. MSc, MPH, PhD) required

• 7+ years of experience required with MSc/MPH/MBA degree; 5+ years of experience required with PharmD/PhD in HEOR or relevant related fields (health economics, epidemiology, health services research, or other research-focused public health field)

• Demonstrated in depth understanding of fundamental health services research methods and tools, including health economic modeling, patient-reported outcomes, statistics, and real-world evidence studies including technical and methodological aspects of registries and observational study design, implementation, analysis and interpretation. Capable of independently managing complex non-interventional study projects

• Knowledge and understanding of drug development process and the US healthcare /economic environment.

• Excellent interpersonal skills required: ability to understand and respond to multiple internal and external customers

• Excellent oral and written English communication skills

• Demonstrated ability to assess anticipated value for projects/programs to ensure alignment to business priorities and prioritize accordingly

• An “execution mindset” focused on getting things done quickly and simply

• Strong project management abilities (contracting, budgeting, vendor management) essential. Demonstrated ability to manage multiple projects (multitask) involving complex processes, significant budget, competing deadlines and rapidly shifting priorities

• Ability to influence key members of medical, clinical, cross-alliance and commercial teams constructively and without conflict

• Skilled in functioning within a matrix organization by managing through influence

• Organized and detail oriented with the ability to anticipate needs and to work proactively to prioritize & address/resolve

• Change oriented, comfortable responding to unexpected demands with tight timelines; team player

PREFERRED QUALIFICATIONS

• Demonstrated ability to manage and oversee real-world evidence studies involving clinical sites, medical record review, chart abstraction vendors, data quality oversight, protocol-aligned abstraction processes, and operational execution from study start-up through analysis and reporting is preferred.

• Knowledge and experience in the oncology therapeutic area with lung cancer experience preferred.

• Experience with the US healthcare environment.

• Experience with HTA organizations/submissions such as ICER, CMS-IPAY (IRA) and other HTA groups such as NICE.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Ability to travel domestically and internationally based on business needs

• Ability to work in all US time zones

Other Job Details:

• Last Date to Apply for Job: September 01, 2026

• NOT Eligible for Relocation Package

• Position is hybrid and will require to work 2/3 days a week from site

The annual base salary for this position ranges from $176,600.00 to $294,300.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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Market Access