Director, Clinical Data Management

Revolution Medicines; San Francisco (CA); On-site; USD 211,000 - 264,000; Full time

Job summary

Revolution Medicines is seeking a Director of Clinical Data Management to oversee day‑to‑day CDM activities for multiple trials at the Redwood City, CA headquarters. This on‑site role involves defining data management strategy, coordinating CROs and data vendors, and ensuring accuracy and consistency across studies.

You will lead a team, drive data standards and SOPs, review CRFs, and manage timelines, while collaborating with cross‑functional teams to advance late‑stage oncology programs in a

Qualifications

• 15+ years of direct experience designing and running clinical trials
• Knowledge of clinical databases, terminology, medical coding dictionaries, QC and auditing
• Strong knowledge of ICH, FDA and GCP regulations and guidelines
• Demonstrated leadership and teamwork ability
• Thrives in collaborative, high-energy environment with innovative approaches
• Industry experience required

Responsibilities

• Plan, coordinate and manage CDM tasks for clinical studies
• Act as liaison with CROs, medical vendors, and EDC vendors
• Review protocols and cross-functional plans
• Lead CRF design and CRF completion guidelines
• Oversee EDC database development, testing and lock/unlock
• Ensure adherence to Data Management Plans throughout studies
• Set and manage Data Management timelines and deliverables
• Provide status updates to project teams
• Assist in data listings, table validation and data transfers for stats review
• Mentor internal data management staff and drive SOP development
• Coordinate data standardization and data model maintenance

Skills

Clinical trial leadership

ICH/GCP knowledge

Regulatory compliance

Vendor management

Data management

Team mentoring

Cross-functional collaboration

Excellent communication

Education

MS/BS/BA degree in related field

Job description

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity

This position has a key role in the day‑to‑day management of Clinical Data Management (CDM) activities. It includes timely and professional management of clinical trial data for all relevant phases, representing Revolution Medicines (RevMed) CDM in Clinical Team meetings, and collaborating closely with other functional leaders to ensure clinical trial success. The Director, Clinical Data Management, will define project‑level data management strategy, identify requirements for capturing and processing clinical data to ensure accuracy, consistency, and completeness, manage external vendors providing clinical data, and perform data management tasks to strict quality standards—including SAE reconciliation, third‑party vendor data reconciliation, medical coding processing, protocol deviation collection, and query management to identify and resolve errors and inconsistencies in clinical data. The role also provides CDM oversight of outsourced and partner‑resourced clinical trials, including scoping trials, project management, relationship management, approval of deliverables, and coordination of internal reviewers.

• Plans, coordinates, and manages CDM tasks for clinical studies.
• Participates in reviewing CRO proposals.
• Acts as primary liaison with CROs, third‑party data vendors, and EDC vendors.
• Reviews clinical protocols and cross‑functional plans.
• Serves as primary reviewer or author of case report forms (CRFs) and CRF completion guidelines.
• Oversees and participates in all aspects of EDC database development, testing, maintenance, and lock/unlock.
• Ensures Data Management Plans are followed throughout the studies.
• Sets and manages Data Management project timelines.
• Provides comprehensive status updates to project team members.
• Addresses data issues identified by cross‑functional team members, accounting for external data vendor documentation, management, and reconciliation.
• Assists in defining and creating data listings, summary table validation, data specifications, and process data transfers in preparation for statistical review and data management audit.
• Implements data standardization and maintains data model across projects.
• Provides direct management and mentoring responsibilities for internal data management team members.
• Leads department initiatives such as development of SOPs.
• Other duties as assigned.

Required Skills, Experience and Education

• MS, BS/BA degree, or other suitable qualification with relevance to the field.
• 15 or more years’ direct experience designing and running early‑stage or late‑stage clinical trials.
• Knowledge of and experience with clinical databases, standards, medical terminology, medical coding dictionaries, quality control processes, and auditing procedures.
• Good working knowledge of ICH, FDA, and GCP regulations and guidelines.
• A demonstrable record of strong leadership and teamwork.
• Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high‑energy environment.
• Excellent written and verbal communication skills.
• Demonstrated ability to multi‑task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team.
• Experience from industry is essential.

Preferred Skills

• Oncology experience, especially in solid tumors.
• 5 or more years’ direct line management experience.

Base Pay Salary Range

$211,000 - $264,000 USD

The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market where a candidate is based. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal‑opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, medical condition, and veteran status.