Director, Bioprocess Engineering

Stanford Climate Ventures; Boulder (CO); Hybrid; USD 175,000 - 225,000; Full time

Benefits offered by this job

401(k)

Medical, dental, and vision plans

Flexible time off

Parental leave

Paid sick leave

Company holidays

Job summary

Alta Resource Technologies in Boulder, CO is seeking a Director of Bioprocess Engineering. You will own end-to-end engineered protein production, building and leading a fermentation and downstream team from shake flask to 10 m³ manufacturing scale.

The role combines internal process leadership with external tech transfer to CROs and toll manufacturers. You will translate bench-scale results into robust, transferable processes, drive cost reductions, and represent Alta's capabilities to partners,

Qualifications

• 12+ years in microbial fermentation with 5+ years in leadership
• Experience building and scaling bioprocess teams
• Hands-on scale-up from shake flasks to 10 m³
• Experience leading technology transfer to external manufacturers
• Experience selecting and managing CROs
• Familiarity with Bacillus fermentation and downstream processing
• Strong written and verbal communication skills
• Experience with data analysis and DOE

Responsibilities

• Own bioprocess strategy for engineered protein production across scales
• Lead fermentation and downstream development from bench to manufacturing
• Define scale-up/scale-down models and key parameters
• Drive titer, yield, and purity improvements via media/feeding strategies
• Oversee technology transfer packages and CRO collaborations
• Provide on-site and remote oversight of campaigns and troubleshoot
• Mentor and develop the bioprocess team
• Document and report progress to leadership

Skills

Industrial fermentation

Leadership

Scale-up

Tech transfer

Data analysis

DOE

Communication

Documentation

Education

B.S./M.S./Ph.D. in chemical/biochemical engineering

Tools

DOE methods

CRO/vendor management

Job description

About Alta

Alta Resource Technologies (Alta) is a next generation mining company that uses synthetic biology to separate critical minerals from conventional and unconventional resources, including e-waste. Founded in 2023, the company is expanding its team in Boulder, CO. The exponential growth of new tech industries, as well as the information technology sector, are driving historic growth in mineral demand and stressing existing supply streams. Meeting new demand, diversifying the supply chain, and producing minerals in a more sustainable manner requires the rapid development, deployment and scaling of new technologies. This mineral challenge represents a historic opportunity for technology development and value creation. Alta is proud to be at the vanguard of this mega trend.

Location: Boulder, CO

Reports To: SVP of R&D

About Us

Alta is reinventing how the world sources critical minerals — using protein-based chemistry to extract rare earth elements and other essential materials from challenging feedstocks with unmatched selectivity. By dramatically reducing the cost and environmental impact of mineral separation, Alta is making it possible to unlock new sources of supply for 21st-century technologies. As global demand accelerates, securing these materials has become one of the most urgent challenges facing U.S. competitiveness and national security. Backed by top investors and government partners, Alta is growing fast and hiring mission-driven scientists and engineers to help us scale our platform and transform the future of mining.

Role Summary

The Director of Bioprocess Engineering will own Alta's end-to-end strategy for producing engineered proteins, from shake flask through 10 m³ manufacturing scale. This is a dual-facing leadership role. Internally, you will build and lead the fermentation and downstream processing team, set technical direction, and drive process development that lowers cost of goods. Externally, you will be Alta's technical lead for technology transfer with contract research organizations (CROs), and toll manufacturing.

The ideal candidate is a proven builder of teams and a hands-on expert in industrial fermentation of Bacillus and other microbial systems. You will translate bench-scale results into robust, transferable processes, represent Alta's bioprocess capabilities to partners, investors, and government stakeholders, and serve as a key member of the technical leadership team.

Key Responsibilities

Internal: Bioprocess Strategy and Development

• Set and own the bioprocess roadmap for engineered protein production, aligned with company cost, capacity, and timeline goals.
• Lead fermentation and downstream process development across scales: shake flask, bench-top bioreactors (1–10 L), pilot scale, and manufacturing scale up to 10 m³.
• Define scale-up strategy and scale-down models, including key scale parameters (kLa, OTR, P/V, tip speed, mixing time, feed strategy) to de-risk transfer to larger vessels.
• Drive improvements in titer, rate, yield, and purity through media optimization, feeding strategies, strain-process integration, and DOE-based experimentation.
• Oversee downstream processing development for protein recovery and purification, with clear KPIs for yield, quality, and cost of goods.
• Evaluate and implement new technologies and process innovations that improve performance or reduce cost.
• Track and report process performance, techno-economic impact, and progress against milestones to executive leadership.

External: CRO, and Partner Leadership

• Serve as Alta's technical lead and primary point of contact for CROs, toll manufacturers and other Partnerships.
• Own technology transfer packages and execution, including process descriptions, batch records, analytical methods, and acceptance criteria.
• Provide on-site and remote oversight of scale-up and manufacturing campaigns; troubleshoot deviations and drive root-cause investigations.
• Manage external project timelines, deliverables, and spend, holding partners accountable to quality and schedule.
• Represent Alta's bioprocess capabilities to investors, government partners, and customers, and support grant and contract deliverables.

Team Building and Leadership

• Build, hire, and scale the bioprocess engineering team, including fermentation and downstream functions.
• Define team structure, roles, and capability development plans as the company grows.
• Lead as a player-coach: remain hands-on at the bench while mentoring and developing scientists and engineers.
• Foster a culture of rigor, collaboration, and accountability.

Communication and Documentation

• Establish best practices for documentation of protocols, experiments, and tech transfer materials.
• Communicate results, risks, and recommendations clearly to cross-functional teams, executives, and external stakeholders.

Required Qualifications

• B.S., M.S., or Ph.D. in chemical engineering, biochemical engineering, or a related field, with 12+ years of industry experience in microbial fermentation (10+ years with a Ph.D.), including at least 5 years in a people-leadership role.
• Demonstrated experience building a team: hiring, structuring, and developing scientists and engineers from early stage to a functioning group.
• Hands-on scale-up of microbial processes from shake flask through bench and pilot scale to manufacturing scale (up to 10 m³ or larger).
• Required experience leading technology transfer of fermentation and downstream processes to external manufacturers.
• Direct experience selecting, managing, and overseeing CROs, including technical oversight of campaigns at partner sites.
• Expertise in fed-batch fermentation of Bacillus for protein production, with a strong understanding of Bacillus cell biology and physiology.
• Experience in downstream processing for protein recovery and purification.
• Track record of KPI-driven process development using data analysis, DOE, and statistical methods.
• Excellent written and verbal communication skills, including presenting to executives, partners, and external stakeholders.
• Strong organizational and documentation skills.

Preferred Qualifications

• Experience with industrial enzymes or other cost-sensitive, high-volume protein products.
• Techno-economic analysis (TEA) and cost-of-goods modeling experience.
• Familiarity with additional microbial hosts (e.g., E. coli, Pichia, Aspergillus).
• Experience supporting government-funded programs (DOE, DOD, DARPA) or working in a startup environment.
• Experience with process analytics, automation, and data systems for bioprocess.

Compensation & Benefits

The starting pay range for this position is $175K - 225K USD, plus equity, commensurate with educational background and work experience. Travel up to 25% time including potentially international travel is a requirement.

Benefits include:

• 401(k)
• Medical, dental, and vision plans (or equivalent)
• Flexible time off
• Paid parental leave
• Paid sick leave
• Company holidays

EOE

Alta Resource Technologies is an equal opportunity employer committed to building a workforce that reflects the diversity of the communities we serve. We believe that varied perspectives, experiences, and backgrounds strengthen our team and drive better outcomes for our clients and partners.

We welcome and encourage applications from all qualified individuals regardless of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected by law. Our hiring decisions are based solely on qualifications, merit, and the needs of the business. Alta participates in e-Verify for all positions.

If you require accommodations at any point in the hiring process, please let your recruiter know.

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