Director, AI and Machine Learning for Biology

Novartis AG; South Dakota; On-site; USD 195,000 - 361,000; Full time

Benefits offered by this job

Performance-based bonus

Equity awards

Health and welfare benefits

401(k) with company match

Job summary

Novartis AG is seeking a Director of AI and Machine Learning for Biology to shape and execute the AI strategy, lead the US data science capability in San Diego, and connect computational and experimental teams with external partners to accelerate target discovery and therapeutic development.

The role requires a PhD in a quantitative field, 10+ years of cross-disciplinary AI experience in biomedicine, and exceptional leadership.

Qualifications

• PhD in Machine Learning, Computational Biology, Data Science, Computer Science, Systems Biology or related quantitative discipline.
• 10+ years applying advanced computational and AI approaches to biomedical research, drug discovery, or translational medicine.
• Proven success leading multidisciplinary global teams across AI, human data, and experimental science.
• Demonstrated experience with foundation models, representation learning, generative models, or multimodal learning across biological data.

Responsibilities

• Lead US DARe Data Science & AI efforts and shape global AI strategy.
• Define prioritized Data Science & AI initiatives with measurable impact.
• Drive AI programs connecting computational and experimental science for target discovery.
• Build and develop a high-performing US-based team in AI, ML, computational biology.

Skills

Strategic leadership

Cross-functional collaboration

Communication

Stakeholder management

Python coding

Deep learning

Multi-modal AI

Model training at scale

Biology knowledge

Education

PhD in Machine Learning

Tools

Python

PyTorch

TensorFlow

Knowledge graphs

Job description

Director, AI and Machine Learning for Biology

Job ID REQ-10089084

Oct 20, 2026

USA

Summary

The Director, Data Science & AI will shape and execute DARe's global AI strategy, lead its US data science capability, and connect computational, experimental, and translational teams and external partners to accelerate target discovery and strengthen DARe’s scientific leadership.

About the Role

Internal Job Title: Director Data Science

About the Role:

DARe is building an AI-enabled discovery engine that integrates longitudinal human data, genetics, multi-omics, imaging, and advanced biological models to uncover causal drivers of aging, resilience, and regeneration. Our goal is to translate these insights into differentiated novel therapeutic targets and medicines for age-related diseases.

We are seeking an exceptional scientific and technical leader to shape DARe’s global Data Science & AI strategy and build our US capability in San Diego. The successful candidate will combine strategic leadership with technical depth to guide high-impact AI programs, connect computational and experimental science, and translate emerging capabilities into meaningful drug-discovery decisions.

Key Responsibilities:

• Lead the US DARe Data Science & AI efforts and shape the global AI and ML strategy
• Define a prioritized portfolio of Data Science & AI initiatives, establish clear measures of scientific and operational impact, and ensure that investments translate into better target decisions, stronger experimental design, and accelerated discovery.
• Co-shape and drive data science and AI efforts supporting target identification, target prioritization, and validation across disease programs and contribute to the DARe long-term scientific AI vision
• Lead the development and application of biological foundation models, multimodal learning, biomedical knowledge graphs, and agentic workflows to drive evidence integration and target prioritization
• Work at the intersection of human genetics, longitudinal clinical trajectories, proteomics, transcriptomics, metabolomics, imaging, and electronic health record data.
• Build, lead, and develop a high-performing US-based team spanning applied AI, machine learning, computational biology, and data science, while creating meaningful growth opportunities for early-career talent.
• Evaluate emerging technologies and establish external partnerships that accelerate DARe's AI capabilities.
• Translate scientific questions into computational strategies, selecting fit-for-purpose statistical, machine learning, AI, and bioinformatics approaches.
• Build strong organizational connectivity to ensure effective collaboration, knowledge sharing, and execution and foster a one-team culture across geographies and scientific disciplines
• Drive AI adoption across the department
• Partner closely with internal functions including Data and Digital, Discovery Sciences and Disease areas
• PhD in Machine Learning, Computational Biology, Data Science, Computer Science, Systems Biology or a related quantitative discipline combined with a deep understanding of biology
• 10+ year experience applying advanced computational and AI approaches to biomedical research, drug discovery, or translational medicine.
• Proven success leading multidisciplinary global teams across AI, human data, and experimental science
• Demonstrated experience developing or applying advanced machine-learning approaches to complex biological data, such as foundation models, representation learning, generative models, or multimodal learning across sequence, single-cell, spatial, imaging, or other biomedical data.
• Strong working knowledge of deep learning, representation learning, multi-modal AI, generative AI, large-scale biological data modeling
• Strong experience in large-scale model training, distributed computation, model adaptation, and deployment within machine learning operations frameworks
• Strong coding proficiency in Python and deep learning frameworks, with experience using version control systems.
• Experience with omics data (transcriptomics, proteomics, metabolomics) and cellular imaging data
• Ability to lead and influence across matrix organizations with exceptional communication and stakeholder management skills.
• Demonstrated ability to operate effectively in a fast-paced and highly collaborative research environment.
• Understanding of modern data foundations including ETL/ELT pipelines, biomedical ontologies, metadata standards, data governance, and FAIR data principles.
• Expertise in diseases of aging, neurodegeneration, cardiometabolic disease, regeneration biology, or related therapeutic areas.
• Experience with knowledge graph technologies and scientific knowledge integration platforms.
• Experience with developing biological aging clocks

Compensation and Benefits:

The salary for this position is expected to range between $194,600 and $361,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills andexperience, and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of therole, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life anddisability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Inaddition, employees are eligible for a generous time off package including vacation, personal days,holidays and other leaves.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility & Reasonable Accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to [e-mail] or call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Division Biomedical Research

Business Unit Research

Location USA

State California

Site LaJolla/SD

Company / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.