Computational Scientist III

Orion Group; South San Francisco (CA); Hybrid; USD 103,320 - 107,452; Full time

Benefits offered by this job

Medical insurance

Vision insurance

401(k)

Job summary

A leading pharmaceutical company is seeking a Computational Scientist for a contract role in South San Francisco. The ideal candidate will have strong Python and R skills, and experience in analyzing spatial transcriptomics and proteomics data. Responsibilities include implementing scripts for data analysis and collaborating with pathologists. This position offers a hybrid working model with competitive pay and benefits.

Qualifications

• Advanced knowledge of analyzing spatial transcriptomics and proteomics data on the CosMx.
• Experience implementing open-source scripts for high-plex image analysis.
• Familiarity with tissue microscopic anatomy and histology is a plus.

Responsibilities

• Implement scripts and pipelines for spatial transcriptomics data analysis.
• Perform high-plex image analysis independently.
• Train team members in spatial analysis tasks.

Skills

Fluency in Python

Fluency in R

Experience analyzing spatial transcriptomics data

Experience analyzing proteomics data

Attention to detail

Excellent verbal communication skills

Education

MSc or PhD in biological sciences/computational biology/engineering/computer science/informatics

Tools

Halo

Visiopharm

QuPath

Job description

This range is provided by Orion Group. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$75.00/hr - $78.00/hr

Direct message the job poster from Orion Group
Hybrid or remote out of South San Francisco
1 year initial contract with possibility of extension
$75 - $78/hr with medical benefits available at a cost

Orion Group and our largest US client are teaming up this holiday season for an exciting contract opportunity for a Computational Scientist. Our client is seeking candidates with a background in Computational Biology and advanced knowledge and experience analyzing spatial transcriptomics and proteomics data generated on the CosMx SMI and PhenoCycler Fusion platforms.

Apply today and head into the new year as a part of a market leading pharmaceutical company.

Purpose:

The Precision Medicine Pathology team drives the scientific strategy for translational tissue‑based biomarker development & discovery target validation/MOA projects, leads pathology collaborative programs, conducts histopathological evaluation & analysis of IHC & spatial biology technologies, and provides technical/scientific leadership to histotechnicians & pathology scientists.

The successful candidate will have advanced knowledge and experience analyzing spatial transcriptomics and proteomics data generated on the CosMx SMI and PhenoCycler Fusion platforms.

Responsibilities:

• Implementation of different scripts and pipelines for spatial transcriptomics data analysis and analysis of high‑plex PhenoCycler Fusion (CODEX) images.
• Independently performing end‑to‑end high‑plex image analysis (tissue classification, cell segmentation, detection of marker positivity, cell phenotyping, unsupervised clustering, neighborhood analysis, proximity analysis).
• Acting as a subject matter resource and training other team members in spatial analysis tasks.
• Collaborating with pathologists and digital pathology scientists to support spatial biology projects.
• Presenting the results and findings from spatial biology studies to stakeholders.

Qualifications needed:

• MSc, PhD, or equivalent degree in biological sciences / computational biology / engineering / computer science / informatics
• Fluency in Python and R is a must have
• Experience analyzing spatial transcriptomics and proteomics data generated on the CosMx is a must have
• Experience in implementing and utilizing open‑source scripts and pipelines for high‑plex image analysis
• Experience in quantitative digital pathology analysis platforms such as Halo, Visiopharm, QuPath
• Close familiarity with tissue microscopic anatomy and histology (normal and diseased) is a plus
• Excellent verbal communication skills are required including the demonstrated ability to effectively and clearly summarize results for presentation and report generation
• Strong motivation, attention to detail, ability to think independently and fully integrate into a high achieving team environment
• Ability to multi‑task and manage multiple projects

Our role in supporting diversity and inclusion

As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.

Seniority level

Mid‑Senior level

Employment type

Contract

Job function

Science

Benefits

Medical insurance
Vision insurance
401(k)