Computational Protein Design Scientist (Hybrid)

Generate:Biomedicines; Somerville (MA); Hybrid; USD 80,000 - 120,000; Full time

Job summary

Generate:Biomedicines in Somerville, MA is looking for a Computational Scientist to join our Model-Driven Design team. This role focuses on advancing therapeutic development via machine learning and structural biology, requiring expertise in protein design and related computational methods. The ideal candidate will have a PhD and experience with modern machine learning models. We offer a flexible hybrid work environment and a competitive benefits package.

Qualifications

• 0-2 years of experience applying computational and/or ML methods to protein design.
• Hands-on experience with modern methods for protein design.
• Strong structural intuition and understanding of protein biophysics.

Responsibilities

• Develop and validate de novo protein generation protocols.
• Design and implement biophysical and functional metrics.
• Evaluate new models and tools for therapeutic development.

Skills

Protein design

Machine learning

Python

Generative modeling

Structural biology

Education

PhD in Computational Biology, Biophysics, Computer Science, or a related field

Tools

RFDiffusion

ProteinMPNN

BindCraft

BoltzDesign

Job description

Generate:Biomedicines in Somerville, MA is looking for a Computational Scientist to join our Model-Driven Design team. This role focuses on advancing therapeutic development via machine learning and structural biology, requiring expertise in protein design and related computational methods. The ideal candidate will have a PhD and experience with modern machine learning models. We offer a flexible hybrid work environment and a competitive benefits package.