Computational Chemistry Research Scientist (Computational Drug Design)

Vertex Pharmaceuticals Inc (US); United States; Hybride; USD 108 000 - 162 000; Plein temps

Résumé du poste

Vertex Pharmaceuticals seeks a highly motivated computational chemist to join its Computational Drug Design group in Boston. You will contribute to hit/lead identification and optimization using molecular modeling, cheminformatics, data science, and AI-enabled methods, collaborating with interdisciplinary project teams.

You will work with the global Data and Computational Sciences group to provide expertise in data analysis, computational chemistry and AI method development, while guiding

Qualifications

• Ph.D. (or equivalent) in Computational Chemistry with 0-3 years relevant experience.
• Expertise in structure-based drug design.
• Experience leveraging AI for design and discovery workflows.
• Strong programming, data analysis, and communication skills.

Responsabilités

• Apply computational chemistry methods to accelerate drug candidate discovery.
• Collaborate with chemists, biologists and project teams to advance candidates.
• Develop workflows and share successful methods within the group.
• Contribute to Vertex's computational chemistry capabilities and tools.
• Support cross-group collaboration with DMPK, Structural Biology and Safety teams.

Connaissances

Computational chemistry

Molecular modeling

Cheminformatics

AI methods

Python

Data analysis

Formation

Ph.D. in Computational Chemistry

Description du poste

Job Description General Summary

We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using a broad range of computational approaches including molecular modeling, cheminformatics, data science, and AI-enabled methods. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively within the global Data and Computational Sciences group to provide expertise in data analysis, computational chemistry and AI method development. This individual must demonstrate strong interpersonal skills and the ability to guide scientists in drug discovery.

Key Duties and Responsibilities

• Apply computational chemistry methods and tools to accelerate the discovery and development of drug candidates, in close collaboration with chemists, structural biologists, biologists and other research project scientists
• Use timely decision making to ensure focus and delivery of key project objectives.
• Promote high levels of productivity and urgency
• Leverage physics-based methods, generative models and machine learning approaches to design new chemical entities
• Proactively work with other computational chemists and cheminformaticians to assess and develop new computational methodologies, create workflows and share successful methods
• Contribute to the further development of Vertex’s computational chemistry capabilities
• Seek out opportunities to improve Vertex’s global R&D capabilities through collaboration with DMPK, Structural Biology, Safety Assessment, and other groups.

Knowledge and Skills

• Excellent interpersonal, communication and presentation skills
• In depth knowledge of state-of-the-advanced computational chemistry and its application in drug discovery
• Experience with commercial and open-source molecular modeling software
• Knowledge of concepts related to drug discovery and development
• Strong solution-oriented attitude, spirit of innovation and creativity, good time and priority management
• Scripting and programming expertise in languages such as Python

Education and Experience

• Ph.D. (or equivalent degree) in Computational Chemistry and 0-3 years of productive, relevant employment experience in computational drug design
• Strong expertise in structure-based drug design
• Experience leveraging modern AI computational capabilities for both design and discovery workstreams
• Proven success influencing teams with computational methods
• Strong programming, data analysis, and communication skills

Pay Range: $108,000 - $162,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status

In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.