Computational Biologist - Single-Cell & Perturbation Genomics

Arc Institute; Palo Alto (CA); On-site; USD 135,000 - 187,000; Full time

Job summary

Arc Institute in Palo Alto seeks two Scientists for its Computational Technology Center to convert large-scale Perturb-seq and single-cell data into mechanistic biological insights.

You will collaborate with experimentalists and ML researchers, apply state-of-the-art analyses, and help drive open-science initiatives across the lab. A PhD with strong data skills is required, and work will be done largely on-site.

Qualifications

• PhD in computational biology, bioinformatics, genomics, systems biology, ML, CS, molecular biology or related field.
• 0–4 years of postdoctoral or professional research experience.
• Demonstrated track record deriving biological insight from large-scale single-cell, perturbational, or multi-omic data.
• Hands-on experience with single-cell, perturbational, or multi-omic data and large datasets.
• Expertise in Perturb-seq/CRISPR screens or single-cell analysis in neurodegeneration context.

Responsibilities

• Conduct tertiary analyses of Perturb-seq, single-cell, multi-omic datasets to relate genes, programs, and phenotypes.
• Work on track-specific tasks like guide assignment, perturbation-effect estimation, or microglia trajectory analysis.
• Partner with experimental teams for study design, interpretation, and validation; translate insights into hypotheses.

Skills

Python proficiency

Single-cell analysis

CRISPR screens

Data analysis

Communication skills

Education

PhD in computational biology

0–4 years postdoc/experience

Tools

Git

Cloud computing

Jupyter

Linux/HPC

Job description

Arc Institute in Palo Alto seeks two Scientists for its Computational Technology Center to convert large-scale Perturb-seq and single-cell data into mechanistic biological insights.

You will collaborate with experimentalists and ML researchers, apply state-of-the-art analyses, and help drive open-science initiatives across the lab. A PhD with strong data skills is required, and work will be done largely on-site.