Computational Biologist (AI/ML) - Essex Management

The Emmes Company, LLC; Rockville (MD); Remote; USD 55,000 - 96,000; Part time

Job summary

Essex Management, an Emmes Company, seeks a Computational Biologist (AI/ML) to apply advanced AI methods to biomedical datasets in a part-time, US-remote capacity. The role focuses on integrating AI/ML techniques across genomic, proteomic, and clinical data to support translational research and precision medicine.

The candidate will design, test, and optimize AI/ML pipelines, leverage LLMs and RAG for data interoperability, and deliver interpretable reports to stakeholders.

Qualifications

• Bachelor's or advanced degree in bioinformatics or closely related field.
• 2–5 years of relevant professional or research experience.
• Experience applying AI/ML to biomedical or multi-modal datasets.
• Experience with LLMs or RAG approaches preferred.
• Ability to communicate complex results to diverse audiences.

Responsibilities

• Design and implement AI/ML models applied to biomedical data, including genomic, proteomic, and multimodal clinical datasets.
• Apply large language models, retrieval-augmented generation (RAG) techniques, and graph neural networks to biomedical data.
• Develop, test, and optimize pipelines for variant calling and annotation leveraging modern ML workflows and frameworks.
• Curate, model, and integrate genetic and clinical datasets into standardized, interoperable formats.
• Generate high-quality, interpretable reports for internal and external stakeholders.

Skills

Python

SQL

ML frameworks

Git

LLMs / RAG

Genetic variant standards

Cross-functional communication

Education

Bachelor's degree or advanced degree in bioinformatics, computational biology, data science, genetics, biology, health informatics, clinical research, or related field

Tools

HGVS

VCF

Job description

Overview

Job Title: Computational Biologist (AI/ML)- Essex Management

Notice to Applicants: This is a Part-Time job.

Location

US Remote

About Essex

This position supports "Essex, an Emmes Company". Essex is a biomedical informatics and health information technology-focused consultancy founded in 2009 and headquartered in Rockville, MD. The Essex team comprises experts with extensive experience in strategically developing and managing complex health and biomedical information programs for clients in the Federal Government, research academia, and private sectors.

Primary Purpose

The Computational Biologist (AI/ML) is a role within the Bioinformatics Department of the BIDS Division at Essex. This role brings meaningful scientific and technical expertise to the design, execution, and delivery of bioinformatics work across federal biomedical research programs. The Computational Biologist (AI/ML) owns well-defined tasks and small projects with minimal supervision and contributes substantively to team problem-solving and scientific quality. This role specifically focuses on applying Artificial Intelligence, Machine Learning and Deep Learning to bioinformatic analysis, and thus the ideal candidate is expected to leverage traditional bioinformatic techniques as well as emerging techniques. Essex supports programs in precision oncology, cancer genomics, clinical data infrastructure, and translational research, and the Computational Biologist (AI/ML) is expected to bring scientific judgment and technical capability to the work, not just execution.

Responsibilities

Core Functions

• Own and execute well-defined analytical and technical tasks and small projects with minimal supervision from senior staff or your manager.
• Assist Associate Informaticists with task-related questions, troubleshooting, and orientation.
• Contribute substantively to team discussions on methodology, standards, tools, and technical decisions.
• Apply working familiarity with best practices in your domain to deliver scientifically sound, high-quality work products.
• Support peer review of deliverables and contribute to quality assurance activities.
• Contribute to team documentation, SOPs, and knowledge base materials.
• Shadow senior staff during candidate interviews to begin developing evaluation skills.
• Participate in internal training sessions, brown bags, and knowledge-sharing activities.
• Perform other related duties as assigned.

Role-Specific Functions

• Design and implement AI/ML models applied to biomedical data, including genomic, proteomic, and multimodal clinical datasets, to support precision oncology and translational research.
• Apply large language models, retrieval-augmented generation (RAG) techniques, and graph neural networks to make biomedical data interoperable and AI-ready.
• Develop, test, and optimize pipelines for variant calling and annotation leveraging modern ML workflows and frameworks.
• Curate, model, and integrate genetic and clinical datasets into standardized, interoperable formats to support precision medicine programs.
• Generate high-quality, interpretable reports for internal and external stakeholders that translate complex AI/ML outputs into actionable scientific and clinical insights.

Qualifications

Required skills

Core Skills

• Working proficiency in the core technical tools, analytical approaches, and data standards relevant to the assigned program and department.
• Ability to work independently and within a team in a fast-paced, collaborative environment.
• Strong written and oral communication skills, including the ability to document work clearly and present findings to technical audiences.
• Proficiency with Microsoft Office applications.

Role-Specific Skills Core Skills

• Proficiency in Python and SQL; demonstrated experience with ML frameworks (PyTorch, TensorFlow) and code versioning (Git).
• Strong background in machine learning and AI, including deep learning architectures (CNNs, GNNs) applied to biomedical or complex multi-modal datasets.
• Familiarity with genetic variant standards (HGVS, VCF) and clinical data ontologies.
• Demonstrated ability to work cross-functionally and communicate technical results clearly to diverse scientific and clinical audiences.

Required experience

Core Experience

• Bachelor's degree or advanced degree in bioinformatics, computational biology, data science, genetics, biology, health informatics, clinical research, or a related field.
• 2 to 5 years of relevant professional or research experience.

Role-Specific Experience

• Demonstrated success applying AI/ML to biomedical or multi-modal datasets (genomics, proteomics, clinical).
• Track record of publications or applied innovation in AI-driven data science for life sciences preferred.
• Experience applying LLMs or RAG approaches to scientific or clinical data problems preferred.

Emmes Group: Building a Better Future for Us All

Emmes Group is transforming the future of clinical research, bringing the promise of new medical discovery closer within reach for patients. Emmes Group was founded as Emmes more than 47 years ago, becoming one of the primary clinical research providers to the U.S. Government before expanding into public-private partnerships and commercial biopharma. Emmes has built industry-leading capabilities in cell and gene therapy, vaccines and infectious diseases, ophthalmology, rare diseases, and neuroscience.

We believe the work we do has a direct impact on patients' lives and act accordingly. We strive to build a collaborative culture at the intersection of being both performance-driven and people-driven. We're looking for talented professionals eager to help advance clinical research as we work to embed innovation into the fabric of our company. If you share our passion for research, come join us.