Commercial Engineer (Strategy & Operations)

Praxis Precision Medicines, Inc.; Boston (MA); Remote; USD 215,000 - 240,000; Full time

Job summary

Praxis Precision Medicines, Inc. is seeking a Director of Commercial Excellence to lead the end-to-end operating model of our brand.

You will partner with Commercial, Medical Affairs, Market Access, Trade, and Finance to drive evidence-based improvements and strategic execution across the organization. Responsibilities include owning the integrated brand operations, tracking performance, and guiding cross-functional teams and external vendors through launch readiness and operating-model

Qualifications

• Bachelor's degree in a relevant field; extensive pharma/biotech commercial operations experience.
• Strong expertise in aligning commercial strategy, data, systems, workflows and vendors to drive brand performance.
• Strategic, analytical problem solver who communicates clearly and drives ownership across teams.

Responsibilities

• Own end-to-end operations for the brand and define the vision for commercial excellence.
• Define and monitor the integrated view of how the brand operates, surfacing risks early.
• Collaborate with senior leaders across Commercial, Medical Affairs, Market Access, Trade & Distribution, and Finance.
• Lead cross-functional initiatives like launch readiness and operating-model redesign without direct reports.
• Translate market dynamics and trends into actionable strategic recommendations for leadership.

Skills

Strategic thinking

Cross-functional collaboration

Data-driven decision making

Executive communication

Education

Bachelor's degree

Job description

Location: This position may be performed remotely but requires flexibility and a willingness to travel as needed.

Position Summary

The Director, Commercial Excellence leads end-to-end operation of the brand’s commercial model, ensuring strategy, workflows, systems, people, and data work together to support effective execution. You will set the standard for how the commercial organization operates, continually monitor and challenge the brand’s operating model and strategic assumptions, make evidence-based recommendations, and partner with senior leaders across Commercial, Medical Affairs, Market Access, Trade & Distribution, and Finance to improve results, acting with urgency whenever brand performance is at risk.

Primary Responsibilities

• Own end-to-end operations for the brand. Lead the design and completion of the commercial build and serve as the organization’s authority on the strategy, workflows, systems, vendors, and data that support the brand. Define and lead the vision for commercial excellence.
• Drive operational performance — Define and own the integrated view of how the brand operates, tracking performance against goals and surfacing risks before they evolve.
• Diagnose and resolve cross-functional issues — Partner with senior functional leaders, up to and including the leadership team, to align on priorities, identify issues and root causes, and drive timely resolution, sharing accountability for outcomes and acting with urgency when commercial performance is at risk.
• Challenge and improve the operating model — Continuously question strategic assumptions and existing processes, using evidence-based analysis to recommend improvements that strengthen commercial performance. Present recommendations directly to leadership team.
• Shape strategy through business insights— Lead the research and intelligence agenda in partnership with cross-functional leaders, translating market dynamics, competitor activity, and emerging trends into actionable recommendations that inform strategic decisions and strengthen commercial performance.
• Lead without authority at scale – Direct the work of matrixed, cross-functional teams and external vendors on the highest-impact commercial initiatives, such as launch readiness and operating-model redesign, without formal direct reports.

Qualifications and Key Success Factors

• Bachelor's degree required; with extensive experience in pharma/biotech commercial operations, brand management, consulting, or related commercial/strategic roles
• Recognized expertise in how commercial strategy, data, systems, workflows, and vendors come together to drive brand performance across a commercial portfolio
• Strategic, analytical problem solver who sees across functions, brings clarity to complex issues, identifies root causes, and translates evidence into actionable recommendations—following through until issues are resolved. High ownership and urgency; steps into ambiguity, challenges assumptions, and acts when performance is at risk
• Credible, collaborative influencer who can align and challenge executive and senior cross-functional leaders, including the leadership team, without relying on authority
• Curious, resilient, and constantly looking for a better way to operate and deliver results
• The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

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$215,000 - $240,000 USD

Compensation & Benefits

At Praxis, we believe that taking care of our people (and

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion

Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.