Cohen Lab- Postdoctoral Fellow

The Chronicle Of Higher Education, Inc.; Aurora (CO); On-site; USD 63,480 - 77,076; Full time

Job summary

The Cohen Lab at the University of Colorado Anschutz Medical Campus is seeking a Postdoctoral Fellow to study trauma-induced coagulopathy and thromboinflammation. The role focuses on translational research using human samples, mouse models, and multiomics to map the protein C pathway and its therapeutic modulation.

Candidate will work in a NIH/DoD/DARPA-funded environment with access to state-of-the-art core facilities and a multidisciplinary team.

Qualifications

• PhD required in biochemistry, molecular biology, cell biology, bioengineering, or a closely related field.
• Experience with endothelial cell models, microfluidic/flow systems, rodent models, and/or multiomics preferred.

Responsibilities

• Contribute to NIH/DoD/DARPA-funded projects on the protein C pathway and coagulation biology.
• Perform translational research using human biorepository samples, mouse models, and 3D endothelial flow systems.
• Collaborate within a multidisciplinary team to advance therapeutics development and data analysis.

Skills

Biochemistry

Molecular biology

Cell biology

Bioengineering & flow models

Animal models

Multiomics

Education

PhD in biochemistry, molecular biology, cell biology, bioengineering, or related field

Job description

University of Colorado Anschutz Department: Department of Surgery- GITES Job Title: CohenLab- Postdoctoral Fellow Position #:00851218 – Requisition#:40643

Job Summary

NIH/DoD/DARPA-funded lab studying trauma-induced coagulopathy andthromboinflammation. Focus on protein C system biology, endothelialdysfunction, and novel therapeutics. Translational approach spanshuman biorepository, mouse models, and multiomics.

The Cohen Lab at CU Anschutz (NIH/DoD/DARPA-funded) seeks apostdoctoral fellow supported by the NIH T32 Critical Injury andIllness Training Program. The R01-funded project centers on theprotein C pathway as the mechanistic bridge between trauma-inducedcoagulopathy (TIC) and thromboinflammation. Work uses human traumabiorepository samples, validated mouse models of hemorrhagic shock,a 3D endothelial flow model, and high-throughput proteomics,metabolomics, and lipidomics. Projects include therapeuticmodulation of APC activity via nanobodies and engineered variants,endothelial barrier and calcium signaling assays, and multiomicphenotyping of post-injury states. Candidates should hold a PhD inbiochemistry, molecular biology, cell biology, or bioengineeringwith experience in endothelial cell models, microfluidic/flowsystems, rodent models, and/or multiomics. Strong interest intranslational research at the intersection of coagulation,inflammation, and therapeutics is required.

Active Research Projects

The fellow will contribute to ongoing R01-funded aims focused on:(1) mechanistic characterization of protein C pathway activation intrauma-induced coagulopathy using clinical patient samples and exvivo mixing studies with APC-selective nanobodies and engineeredsuperFVa; (2) endothelial biology of thromboinflammation includingbarrier function, calcium signaling, and mitochondrial metabolicdysfunction studied in a novel 3D flow model and validated mousemodels of hemorrhagic shock; and (3) multiomic (proteomic,metabolomic, lipidomic) endotyping of post-injury phenotypes andtrajectories using a biorepository of >10,000 samples fromseverely injured patients.

Training & Mentorship

The fellow will be co-mentored by Dr. Mitchell J. Cohen MD FACS(trauma surgeon-scientist, Professor of Surgery, Bruce RockwellChair) and a multidisciplinary team including experts incoagulation biology, proteomics/metabolomics, thrombosis modeling,and bioengineering. The NIH T32 Critical Injury and IllnessTraining Program provides structured training in grant writing,scientific communication, and career development. The fellow willhave access to state-of-the-art core facilities at CU Anschutzincluding mass spectrometry, flow cytometry, high-resolutionmicroscopy, and a dedicated Level 1 Trauma Centerbiorepository.

Work Location

Onsite – this role is expected to work onsite and is located in Aurora, CO.

Why Join Us

The Department of Surgery's leading-edge research programs focus on the search for the next cure, newest innovations, and breakthroughclinical trials. Our faculty, researchers, and students arerelentless in their pursuit of discoveries that will transform thefuture of surgery.

The University of Colorado Anschutz Medical Campus is acomprehensive urban research university serving more than 28,000students in metropolitan Denver and online. With our solid academicreputation, award-winning faculty and renowned researchers, weoffer 119 highly rated degree programs through 13 schools andcolleges. The University of Colorado Anschutz Medical Campus iswell known for its distinctive and highly productive researchprograms, its world-class health facilities at the Anschutz MedicalCampus, and its well-established partnerships in business,industry, and government. These campuses currently have over $757million in research awards each year.

Why work for the University?

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post-Doctoral Fellows,please visit:

• Payroll & Benefits Orientation for Post-Doctoral Fellows |University of Colorado (cu.edu)
• benefits guide cover-post-doc-2024 (cu.edu)

Qualifications

Minimum Qualifications

Applicants must meet minimum qualifications at the time of hire.

• PhD in biochemistry, molecular biology, cell biology, bioengineering, or a closely related field.

Preferred Qualifications

• Biochemistry: protein biochemistry, enzyme kinetics, coagulation assays, recombinant protein expression
• Molecular biology: gene expression analysis, RiboTag/RNA-seq, CRISPR, cloning
• Cell biology: endothelial cell culture, barrier function assays, calcium imaging, confocal microscopy
• Bioengineering & flow models: microfluidic systems, 3D flowchamber assays, hemodynamic modeling
• Animal models: in vivo mouse models of trauma, hemorrhagic shock,or critical illness
• Multiomics: proteomics, metabolomics, lipidomics, or bioinformatic data analysis

Conditions of Employment

• Applicants must be legally authorized to work in the UnitedStates without requiring sponsorship. We are unable to provide workvisa sponsorship or employment authorization for this position nowor in the future.

Anticipated Pay Range

The starting salary range (or hiring range) for this position has been established as HIRING RANGE:

$63,480- $77,076

The above salary range (or hiring range) represents theUniversity's good faith and reasonable estimate of the range ofpossible compensation at the time of posting. This position is noteligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plansand retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

Equal Employment Opportunity Statement

The University of Colorado (CU) is an Equal Opportunity Employerand complies with all applicable federal, state, and local lawsgoverning nondiscrimination in employment. We are committed tocreating a workplace where all individuals are treated with respectand dignity, and we encourage individuals from all backgrounds toapply, including protected veterans and individuals withdisabilities.

ADA Statement

The University will provide reasonable accommodations to applicantswith disabilities throughout the employment application process. To request an accommodation pursuant to the Americans withDisabilities Act, please contact the Human Resources ADACoordinator at [e-mail].

Background Check Statement

The University of Colorado Anschutz Medical Campus is dedicated toensuring a safe and secure environment for our faculty, staff,students and visitors. To assist in achieving that goal, we conductbackground investigations for all prospective employees.

Vaccination Statement

CU Anschutz strongly encourages vaccination against the COVID-19virus and other vaccine preventable diseases. If you work, visit, or volunteerin healthcare facilities or clinics operated by our affiliatedhospital or clinical partners or by CU Anschutz, you will berequired to comply with the vaccination and medical surveillancepolicies of the facilities or clinics where you work, visit, orvolunteer, respectively. In addition, if you work in certainresearch areas or perform certain safety sensitive job duties, youmust enroll in the occupational health medical surveillance program.