Cloud Infrastructure Leader for Scientific Computing

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 172,000 - 237,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Pioneering seeks a Director of Scientific Cloud Engineering to lead cloud and computational infrastructure across its biotech portfolio. You will manage a growing team of Cloud DevOps and Bioinformatics engineers, defining roadmaps and setting engineering standards to scale scientific compute.

You will partner with Data Architecture, Lab Systems, and Research Systems to ensure scalable, reproducible platforms, including HPC, Nextflow, and AI/ML infrastructure, while maintaining a strong

Qualifications

• 10+ years of experience in cloud engineering, infrastructure engineering, or DevOps, with at least 3 years in a technical leadership or engineering management role.
• Deep expertise in AWS (preferred) and/or Azure, including compute, storage, networking, IAM, and managed services for data and ML.
• Demonstrated experience designing and operating infrastructure for scientific or biotech workloads — genomics pipelines, HPC, -omics data processing, or equivalent.
• Strong proficiency in infrastructure-as-code (Terraform, CDK, CloudFormation) and CI/CD automation (GitHub Actions, Jenkins, or similar).
• Experience with containerization and orchestration technologies (Docker, Kubernetes, ECS/EKS).
• Familiarity with bioinformatics workflow frameworks (Nextflow, Snakemake, WDL) and scientific compute environments.
• Background in biotech, life sciences, or pharmaceutical research — through education or direct industry experience in a scientific computing context.
• Track record of building and shipping reusable infrastructure products and reference architectures, not just bespoke solutions.
• Strong communicator who can translate between scientific requirements and engineering specifications, and present technical strategy to non-technical stakeholders.

Responsibilities

• Lead, mentor, and grow , including external contractors and consultants; set a high technical bar and foster a culture of rigor, collaboration, and continuous improvement.
• Serve as a player-coach — providing direct technical contributions while managing team capacity, priorities, and professional development.
• Partner with the Senior Director of Scientific Cloud to define team roadmap, resource allocation, and hiring strategy as the portfolio scales.
• Establish engineering best practices, code review standards, and documentation norms across their Scientific Cloud Engineering team.
• Own and evolve the cloud architecture strategy for Scientific Cloud, designing scalable, secure, and cost-efficient infrastructure across AWS and/or Azure environments.
• Architect and deliver reusable infrastructure-as-code (IaC) solutions — including Terraform modules, CDK constructs, and containerized service templates — that portfolio companies can adopt without custom engineering.
• Partner with Infrastructure, Operations, and Architecture (IO&A) to define and enforce cloud governance guardrails: IAM, networking, secrets management, cost tagging, and security posture.
• Design and maintain HPC and compute environments — including Nextflow/Cromwell execution layers, Kubernetes clusters, and GPU-enabled instances — optimized for scientific workloads.
• Evaluate and adopt emerging cloud capabilities, including serverless orchestration, data lakehouse patterns, and managed ML platforms (e.g., AWS SageMaker, Azure ML).
• and data scientists to architect robust, reproducible pipeline infrastructure for genomics, proteomics, and other -omics data types.
• Oversee the design and deployment of bioinformatics platform capabilities including workflow orchestration (Nextflow, Snakemake), container registries, reference data management, and secure data ingestion from external sources (e.g., UK Biobank, dbGaP, controlled-access repositories).
• Ensure compute environments support the full spectrum of scientific compute: interactive analysis (Jupyter, RStudio), large-scale batch processing, and real-time ML inference.
• Champion FAIR data principles and reproducibility standards in scientific compute infrastructure.
• Develop and steward portfolio-wide engineering standards for cloud infrastructure, security, and scientific compute — ensuring consistency across all Flagship portfolio companies and research teams.
• Design and publish reusable infrastructure products, reference architectures, and deployment templates that enable portfolio companies to launch and scale scientific capabilities quickly.
• Serve as the technical standards interface for internal teams and portfolio companies, reviewing proposed architectures and ensuring alignment with Flagship IT guardrails.
• Collaborate with the Pioneering Intelligence (PI) team and portfolio companies to enable and accelerate AI/ML capabilities — including model training infrastructure, feature stores, vector databases, and LLM deployment patterns.
• Collaborate closely with the Data Architecture & Engineering team to align on data platform design, pipeline standards, and lakehouse infrastructure.
• Partner with Lab Systems and Research Systems teams to ensure cloud infrastructure meets the integration and performance requirements of ELN platforms, LIMS, scientific instruments, and research applications.
• Engage with IT Security and Compliance to maintain a strong cloud security posture, including SOC 2, GxP, and HIPAA-relevant requirements as the portfolio matures.
• Work with portfolio company CTOs and heads of data science and bioinformatics to understand scientific infrastructure needs and ensure Scientific Cloud is delivering ahead of demand.

Skills

AWS

Azure

Cloud architecture

Terraform

CDK

Kubernetes

Nextflow/Snakemake

Bioinformatics workflows

Team leadership

Education

B.S./M.S./Ph.D. in computational biology or related field

Tools

Docker

Kubernetes

ECS/EKS

Terraform

Job description

Flagship Pioneering seeks a Director of Scientific Cloud Engineering to lead cloud and computational infrastructure across its biotech portfolio. You will manage a growing team of Cloud DevOps and Bioinformatics engineers, defining roadmaps and setting engineering standards to scale scientific compute.

You will partner with Data Architecture, Lab Systems, and Research Systems to ensure scalable, reproducible platforms, including HPC, Nextflow, and AI/ML infrastructure, while maintaining a strong