Clinical Project Manager - Oncology (Client Dedicated/Remote)

Syneos Health, Inc.; Connecticut; Hybrid; USD 90,000 - 125,000; Full time

Job summary

Syneos Health, Inc. is seeking a Clinical Project Manager II – Oncology for a fully remote, US-based role focused on advancing cancer therapies through global trials.

The candidate will drive operational leadership, collaborate with cross-functional teams, vendors, and international stakeholders to deliver studies on time and in compliance. The role requires 3+ years of hands-on clinical project management in oncology, strong vendor management, and a deep understanding of trial lifecycles and

Qualifications

• Bachelor's degree in a scientific, healthcare, or related field.
• 3+ years of Clinical Project Management in global oncology trials.
• Experience managing studies across multiple countries and regions.
• Strong working knowledge of ICH-GCP guidelines and clinical research regulations.

Responsibilities

• Drive operational execution of global oncology trials to ensure efficiency and compliance.
• Lead day-to-day study management across startup, conduct, maintenance and closeout.
• Manage study timelines, deliverables, risks and issue resolution.
• Oversee external vendors, CROs, labs and imaging vendors.
• Coordinate Clinical Trial Team (CTT) meetings and action item follow-up.
• Support study planning, forecasting and operational strategy execution.

Skills

Project management

Communication

Stakeholder management

Global/matrix coordination

Team coordination

MS Office Suite

Education

Bachelor's degree in a scientific/healthcare field

Tools

CTMS

eTMF

IRT/RTSM

Microsoft Office

Job description

Clinical Project Manager - Oncology (Client Dedicated/Remote)

Clinical Project Manager - Oncology (Client Dedicated/Remote)

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know:

WORK HERE MATTERS EVERYWHERE

Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives – we’re able to create a place where everyone feels like they belong.

Job Responsibilities

CLINICAL PROJECT MANAGER II – ONCOLOGY

Sponsor Dedicated | Remote – United States

Are you passionate about advancing cancer research and bringing innovative therapies to patients worldwide? We are seeking experienced Clinical Project Managers with strong global oncology clinical trial experience to join a high-performing sponsor-dedicated team supporting a diverse portfolio of oncology studies across multiple indications and phases of development.

This is a fully remote, US-based opportunity where you will play a critical role in the operational leadership and execution of global clinical trials. We are specifically seeking professionals with 3+ years of hands‑on Clinical Project Management experience leading global oncology studies and collaborating with cross‑functional teams, vendors, and international stakeholders.

WHAT YOU'LL DO

As a Clinical Project Manager II, you will help drive the operational execution and delivery of global oncology clinical trials, ensuring studies are conducted efficiently, compliantly, and according to established timelines.

Key Responsibilities

• Support and partner with Clinical Study Leads and cross‑functional study teams on global oncology trials
• Lead day‑to‑day study management activities across study startup, conduct, maintenance, and closeout
• Manage study timelines, deliverables, risks, and issue resolution
• Oversee external vendors, CROs, central laboratories, imaging vendors, and specialty providers
• Coordinate Clinical Trial Team (CTT) meetings and drive action item follow‑up
• Support study‑level planning, forecasting, and operational strategy execution
• Monitor study performance metrics and proactively identify areas requiring intervention
• Ensure inspection readiness and compliance with applicable regulations and sponsor requirements
• Collaborate with stakeholders across Clinical Operations, Data Management, Biostatistics, Medical Monitoring, Regulatory Affairs, Safety, Supply Chain, and Quality
• Contribute to study status reporting and executive‑level communications
• Support achievement of study milestones, enrollment targets, database locks, and study closeout activities

WHAT YOU WILL BRING

Required Qualifications

• Bachelor's degree in a scientific, healthcare, or related field is required
• 3+ years of Clinical Project Management experience supporting global oncology clinical trials
• Experience managing studies across multiple countries and regions (North America, Europe, Asia‑Pacific, Latin America, or other global regions)
• Vendor management experience required
• Strong understanding of clinical trial operations and study lifecycle management
• Experience supporting Phase I, Phase II, Phase III, and/or Phase IV oncology studies
• Strong working knowledge of ICH‑GCP guidelines and clinical research regulations
• Proficiency with Microsoft Office Suite
• Ability to work effectively within global, cross‑functional matrix organizations

ONCOLOGY THERAPEUTIC AREA EXPERIENCE

Candidates should have direct clinical trial experience supporting one or more oncology indications:

• Lung cancer (NSCLC, SCLC)
• Melanoma
• Renal cell carcinoma (kidney)
• Bladder cancer
• Head & neck squamous cell carcinoma
• Triple‑negative breast cancer
• Cervical cancer
• Gastric and gastroesophageal cancers
• Esophageal cancer
• Hepatocellular carcinoma (liver)
• Endometrial cancer
• Ovarian cancer
• Colorectal cancer
• Biliary tract cancer
• Prostate cancer
• Urothelial carcinoma
• Hematologic malignancies (multiple myeloma, lymphoma, leukemia)
• Antibody‑drug conjugates (ADCs)
• Personalized cancer vaccines
• KRAS inhibitors
• T‑cell engagers
• Cell‑directed immunotherapies

Candidates should be prepared to discuss the indications supported, study phases, geographic scope, and their specific responsibilities on each program.

PREFERRED QUALIFICATIONS

• Experience independently leading global oncology studies
• Experience supporting complex, multi‑regional Phase II and Phase III programs
• Experience with early‑phase oncology studies (Phase I/Ib)
• Experience with immuno‑oncology, targeted therapies, cell therapy, or hematologic malignancies
• Familiarity with CTMS, eTMF, IRT/RTSM, and clinical data review platforms
• Experience working in sponsor‑dedicated or FSP environments

KEY SKILLS & COMPETENCIES

• Strong project management and organizational skills
• Excellent communication and stakeholder management abilities
• Proven ability to manage multiple priorities in a fast‑paced environment
• Strong risk identification and mitigation capabilities
• Detail‑oriented with a focus on quality, compliance, and execution
• Strong collaboration skills across global teams and functions
• Ability to influence without direct authority and drive accountability across study teams

CLINICAL PHASE EXPERIENCE

We welcome candidates with experience supporting:

• Phase I / First‑in‑Human Studies
• Phase I/Ib Dose Escalation Studies
• Phase II Proof‑of‑Concept Studies
• Phase II/III Registrational Studies
• Phase III Global Pivotal Trials