Clinical Laboratory Scientist, General Supervisor

10x Genomics; Pleasanton (CA); On-site; USD 140,000 - 189,000; Full time

Job summary

10x Genomics is seeking a Clinical Laboratory Scientist/General Supervisor to oversee high complexity NGS testing in a CLIA-certified lab in California. You will provide technical leadership, supervise staff, ensure accuracy of results, and maintain quality systems.

The role requires active CA CLS license, 2–4 years in high complexity CLIA testing with NGS and regulatory knowledge. Strong leadership, training, and collaboration are essential for success.

Qualifications

• Minimum 2–4 years of experience in high complexity CLIA testing with NGS
• Active California CLS license or CGMBS/generalist license
• Meets CLIA General Supervisor qualifications under 42 CFR 493.1461
• Strong knowledge of CLIA regulations and quality systems
• Experience with NGS platforms, library prep, sequencing, and pipelines

Responsibilities

• Oversee daily operations for high complexity NGS assays
• Supervise and train laboratory personnel, assess competency
• Review QC/QA and assay performance metrics for accuracy
• Maintain regulatory compliance (CLIA, CAP)
• Assist in development/validation/implementation of NGS assays
• Monitor workflow, turnaround times, and resource use
• Troubleshoot instrument, assay, and data analysis issues
• Maintain SOPs, validation reports, and quality records
• Support continuous quality improvement initiatives
• Ensure maintenance and calibration of equipment

Skills

NGS expertise

Laboratory supervision

Quality systems

Bioinformatics pipelines

Regulatory compliance

Education

Bachelor's in CLSL/related

CLIA General Supervisor qualifications

Tools

NGS platforms

Bioinformatics software

Job description

About The Role

10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. This Clinical Laboratory Scientist/General Supervisor position is responsible for the day-to-day execution and oversight of high complexity next-generation sequencing (NGS) testing within a CLIA-certified laboratory. This role ensures the accuracy, reliability, and timeliness of test results while maintaining full compliance with regulatory and quality standards. The General Supervisor provides technical leadership, staff supervision, and operational support to ensure efficient laboratory performance.

What You Will Be Doing

• Perform and oversee daily laboratory operations for high complexity NGS assays, ensuring adherence to established protocols and quality standards.
• Supervise and provide guidance to laboratory personnel, including training, competency assessment, and performance management.
• Ensure the accuracy and validity of test results through review of quality control, quality assurance, and assay performance metrics.
• Maintain compliance with CLIA, CAP, and other applicable regulatory requirements.
• Assist in the development, validation, implementation, and optimization of NGS assays and workflows.
• Monitor laboratory workflow, turnaround times, and resource utilization to ensure operational efficiency.
• Troubleshoot technical issues related to instrumentation, assays, and data analysis.
• Review and maintain laboratory documentation, including SOPs, validation reports, and quality records.
• Collaborate with laboratory leadership to support continuous quality improvement initiatives.
• Ensure proper maintenance and calibration of laboratory equipment.

To Be Successful In This Role, You Will Need

• Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
• Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
• Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
• Minimum of 2–4 years of experience in high complexity CLIA testing, with demonstrated expertise and experience in NGS technologies.
• Prior supervisory or leadership experience preferred.
• Strong knowledge of CLIA regulations and quality systems.
• Experience with NGS platforms, library preparation, sequencing, and bioinformatics pipelines.

Additional Attributes

• Prior experience serving as CLIA General Supervisor
• Startup or high growth laboratory experience
• Background in medical or oncology diagnostics
• Excellent organizational, analytical, and problem-solving skills.
• Strong communication and leadership abilities.

Pay Range

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. At 10x, base pay is also just one component of the Company’s total compensation package. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

$139,700—$188,900 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.