Clinical Development, Medical Director- Neurology

Vertex Pharmaceuticals; Boston (MA); Hybrid; USD 220,000 - 320,000; Full time

Benefits offered by this job

Hybrid-Eligible

On-Site Eligible

Job summary

Vertex Pharmaceuticals seeks a Clinical Development Medical Director to serve as Medical Lead for clinical trials, shaping strategy, design, and execution while monitoring safety. This role collaborates with cross-functional teams across Vertex and may oversee multiple trials across development phases.

Strong leadership in regulatory submissions and scientific input is required. The position emphasizes collaboration in a fast-paced environment with a focus on high-quality study conduct and

Qualifications

• MD/DO or equivalent medical degree.
• Board certification/eligibility in a specialty is highly desired.
• Typically requires 10 years of basic or clinical research experience.
• Experience with clinical trial design, analysis, and reporting.

Responsibilities

• Leads development of study protocols, brochures, and development plans with minimal guidance.
• Serves on cross-functional Study Execution Teams for assigned trials.
• Prepares regulatory documents for submissions including INDs/CTAs and safety reports.
• Provides clinical input to SAP, CSR, ICF, and CRF documents; liaises with internal groups.
• Represents Vertex to external medical personnel in protocol development and study conduct.
• Performs other duties related to clinical programs.

Skills

Medical Lead

Cross-functional

GCP Knowledge

Biostatistics

Education

MD/DO or equivalent

Board certification/eligibility

10+ years experience

Trial design experience

Job description

General Summary:
The Clinical Development Medical Director will serve as the Medical Lead for Vertex clinical trials, working with cross-functional multidisciplinary study teams on clinical trial strategy, design and execution and serving as the Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. The incumbent will work on multiple trials in all Phases of clinical development, and may also participate in other selected projects in clinical development.

Job Description
General Summary:
The Clinical Development Medical Director will serve as the Medical Lead for Vertex clinical trials, working with cross-functional multidisciplinary study teams on clinical trial strategy, design and execution and serving as the Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. The incumbent will work on multiple trials in all Phases of clinical development, and may also participate in other selected projects in clinical development.
Key Duties And Responsibilities

• Leads the development of Study Protocols, Investigator Brochures, Clinical Development Plans and other key study documents in conjunction with other line functions and with minimal guidance
• Serves on cross-functional Study Execution Teams (SET) for assigned trials, working with other team members to achieve efficient, high-quality study execution
• Participates in the preparation of regulatory documents in support of regulatory submissions, including clinical sections of INDs and CTAs, safety reports and annual reports for assigned trials, responses to regulatory authorities and Ethics Committees/IRBs, and other documents as appropriate
• Provides scientific and clinical input to study-related documents and analysis plans including Informed consent forms (ICF), clinical research forms (CRF), statistical analysis plans (SAP), clinical pharmacology analysis plans (CPAP), and clinical study reports (CSR). Acts as liaison between Translational Medicine/Clinical Development and other internal groups at Vertex (e.g., Regulatory Affairs, Clinical Operations) for assigned studies
• Represents Vertex to outside medical personal in the development of clinical protocols and study conduct
• Performs other duties as assigned related to clinical programs
  

Knowledge And Skills

• Excellent oral and written communication skills
• Ability to work collaboratively in a fast-paced, team-based, matrix environment and to function independently as appropriate
• Effective at building alliances across functions, based on end-to-end drug development thinking and experience
• Board certification/eligibility in a medical, pediatric or surgical subspecialty
  

Education And Experience

• MD, DO or equivalent ex-US medical degree
• Board certification/eligibility in a specialty field is highly desired
• Typically requires 10 years of basic or clinical research experience in an academic or industrial setting, or the equivalent combination of education and experience
• Typically requires experience in analysis of research data and publications; working knowledge of biostatistics; working knowledge of GCP, scientific and clinical research methods and clinical study design
• Typically requires experience with design, execution, and analysis of clinical trials required
  

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range
$0 - $0
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status
In this Hybrid-Eligible role, you can choose to be designated as:

• Hybrid: work remotely up to two days per week; or select
• On-Site: work five days per week on-site with ad hoc flexibility.
  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]